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Copper is an essential micronutrient and yet is highly toxic to cells at elevated concentrations. P1B-ATPase proteins are critical for this regulation, providing active extrusion across cellular membranes. One unique molecular adaptation of P1B-ATPases compared to other P-type ATPases is the presence of metal-binding domains (MBDs) at the cytosolic termini, which however are poorly characterized w
The effects of dietary vitamin D, Ca and dairy products intakes on colorectal cancer risk remain controversial. The present study investigated the association between these dietary intakes and the risk of colorectal cancer in Guangdong, China. From July 2010 to December 2018, 2380 patients with colorectal cancer and 2389 sex- and age-matched controls were recruited. Dietary intake data were collec
Group A Streptococcus (GAS)causes infections ranging from mild sore throats to severe invasive disease; however, no licensed vaccine is currently available. In this thesis, the author leverages streptolysin O (SLO), an important GAS protein and therapeutic/vaccine target, as a model system to develop a multimodal protein mass spectrometry(MS) strategy. Through an integrated approach of MS-based pr
Many studies have underscored the impacts of drought on ecosystems, and some researchers reported the effects of accumulated soil moisture deficit (ASMD) on light use efficiency (LUE) in grassland. However, the potential effects of ASMD on gross primary productivity (GPP) and LUE for both cropland and forest ecosystems are still not understood. This study elucidated the effects of accumulated and
Aims: Increased common carotid artery (CCA) intima media thickness (cIMT) is a well-known risk factor for cardiovascular morbidity and mortality. cIMT thickening has been described in patients with repaired aortic coarctation (CoA), but data on mechanism and clinical relevance in this population are scarce. Our aim was to gain mechanistic insights into cIMT thickening of patients with repaired CoA
Mild reductive catalytic depolymerization (MRCD) of lignin offers a sustainable route to produce functionalized aromatic compounds. However, the economic viability is hindered by the need for expensive palladium (Pd) catalysts and the limited exploration of continuous flow reactors (CFRs), which are essential to achieve an adequate production scale. This study examines the impact of partial replac
The serine protease cathepsin G is synthesized during the promyelomonocytic stage of neutrophil and monocyte differentiation. After processing, including removal of an amino-terminal propeptide from the catalytically inactive proform, the active protease acquires a mature conformation and is stored in azurophil granules. To investigate the importance of the proform-conformation for targeting to gr
Cryptic genetic differentiation is being increasingly documented in birds and other organisms using genome-wide variation. A recent example of cryptic genetic differentiation in a widespread species with conserved morphology is the northern house wren Troglodytes aedon. We found that, despite extremely similar morphology and no documented vocal differences, the two subspecies of the northern house
The Oriental fruit moth Grapholita molesta is distributed throughout temperate regions and considered to be a pest in peach production and other high-value fruit crops in the rose family. Insecticide treatment has led to resistance development, but the use of sex pheromones in pest management has shown great promise. We investigated the pheromone biosynthesis pathway in G. molesta with the aim of
Plast präglar i stort sett allting i det moderna livet och bidrar till miljöförstöring och avfallsgenerering på global nivå. Denna avhandling undersöker hur plastavfall blev djupt inbäddat i Sveriges kulturella, politiska och ekonomiska strukturer. Med hjälp av ett ramverk baserat på kulturell politisk ekonomi (CPE) används tre perspektiv - hegemoni, inlåsningseffekter och praktiker - för att analPlastic disposability is a pervasive feature of modern life, contributing to environmental degradation and waste generation on a global scale. This dissertation investigates how plastic disposability became deeply embedded within Sweden's cultural, political, and economic structures. Using a Cultural Political Economy (CPE) framework, it applies three lenses – hegemony, lock-in, and practice – to
Nanochains (NCs) made up of a one-dimensional arrangement of magnetic anoparticles (NPs) exhibit anisotropic properties with potential for various applications. Herein, using a novel self-assembly method we directly integrate single NCs onto desired substrates including devices. We present a nanoscopic analysis of magnetization reversal in 1D linear NP arrays by combining x-ray microscopy, magnet
Background: In COPD, the balance between matrix metalloproteinases (MMPs) and their natural inhibitors [tissue inhibitors of metalloproteinases (TIMPs)] is shifted towards excessive degradation, reflected in bronchoalveolar lavage (BAL) as increased MMP concentrations. Because of their critical role in lung homeostasis, MMP activity is tightly regulated, but to what extent this regulation occurs t
Advances in Earth observation capabilities mean that there is now a multitude of spatially resolved data sets available that can support the quantification of water and carbon pools and fluxes at the land surface. However, such quantification ideally requires efficient synergistic exploitation of those data, which in turn requires carbon and water land-surface models with the capability to simulta
The emergence of the modern urban water system in Iran, albeit facilitated access to clean water and accelerated discharge of waste- and stormwater, it left some negative imprints on country’s urban and natural environment. Among which larger stress on natural water cycles and pollution of water resources are of great importance. More importantly, such impacts are occurring when cities are going t
Extremely thinned layers and possible folding make the dating of the deepest sections of ice cores especially challenging. Cosmogenic radionuclides have the potential to provide independent age estimates. The 36Cl/10Be ratio is largely independent of production rate changes that affect individual radionuclides and has an effective half-life of 384 kyr, making it an ideal tool for dating the new 1.
Purpose: Avian haemosporidians are widespread parasites, occurring in many bird families and causing pathologies ranging from rather benign infections to highly virulent diseases. The state of knowledge about lineage-specific intensities of haemosporidian infection (i.e., parasitaemia) is mainly based on infection experiments conducted under laboratory conditions. The levels and range of parasitae
