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Background: After an esophageal resection, continuity is commonly restored by a gastric tube reconstruction and an intrathoracic anastomosis to the remaining proximal esophagus. Ischemia of the anastomotic region is considered to play a pivotal role in anastomotic leakage. Microdialysis (μD) is an excellent method to measure local biochemical substances and parameters in a specific organ or compar

Cak1p is an essential protein kinase that phosphorylates and thereby activates the major cyclin-dependent kinase in budding yeast, Cdc28p. The sequence of Cak1p differs from other members of the protein kinase superfamily in several conserved regions. Cak1p lacks the highly conserved glycine loop motif (GXGXXG) that is found in the nucleotide binding fold of virtually all protein kinases and also

Mitochondrial creatine kinase (Mi-CK) isoenzymes, in contrast to cytosolic CKs, form octameric molecules composed of four stable dimers. Octamers and dimers are interconvertible. Removal of the N-terminal pentapeptide of chicken cardiac Mi-CK (Mib-CK) by limited proteolysis drastically destabilized the octamer. The role of the charged amino acids within the N-terminal heptapeptide was studied in d

Purpose of Review This study aimed to review the literature regarding the mechanisms of transition from asymptomatic colonization to induction of otitis media and how the insight into the pathogenesis of otitis media has the potential to help design future otitis media-directed vaccines. Recent Findings Respiratory viruses have long been shown to predispose individuals to bacterial respiratory inf

According to the waste hierarchy principle, which constitutes the basis of European waste legislation, waste prevention and re-use are considered – most of the times – better waste management options than recycling. However, prevention and re-use activities are difficult to operationalise and measure, without a monitoring framework in place. This contribution investigates the potential of re-using

Many industries have benefited from modularisation; while in the architecture, engineering and construction (AEC) industry, the concept of modularisation is associated with dimensional coordination. This has added to an already extensive list of challenges due to market size and the concept of economies of scale in AEC industry, to name but a few. Moreover, there is a myth that the AEC industry is

The SWEDEGRAFT study (ClinicalTrials.gov Identifier: NCT03501303) tests the hypothesis that saphenous vein grafts (SVGs) harvested with the “no-touch” technique improves patency of coronary artery bypass grafts compared with the conventional open skeletonized technique. This article describes the rationale and design of the randomized trial and baseline characteristics of the population enrolled d

Grotta dei Santi represents a very suitable investigation field for carrying out an inquiry into the Neandertal behaviour at a high-resolution time scale, in order to obtain data useful for the “functional” reading of the economic and settling strategies. This cave opens into the Monte Argentario Promontory (southern coast of Tuscany, central Italy), almost at sea-level, at the base of a limestone

Birds that are foraging in tree canopies can cause a substantial decrease in arthropod numbers. Trees may benefit from avian insectivores attacking insect herbivores. In a field study, we tested whether the intensity of bird predation on caterpillars is linked quantitatively to leaf damage caused by insect herbivores, a hypothesized relationship that previously was poorly investigated. Artificial

Compounds containing lone-pair elements such as TeIV are very interesting from the structural point of view, as the lone-pair nonbonding regions create low-dimensional geometrical arrangements. We have synthesized two new compounds with these features - Ba2Cu2Te 4O11Br2 (I) and Ba2Cu 2Te4O11-δ(OH)2δBr 2 (II, δ ≈ 0.57) - as members of the AE-M-Te-O-X (AE = alkaline-earth metal, M = transition metal

We present a combined experimental and theoretical study of the structure and the lattice dynamics in the complex metallic alloy Mg2Zn 11, by means of neutron and x-ray scattering, as well as ab initio and empirical potential calculations. Mg2Zn11 can be seen as an intermediate step in structural complexity between the simple Laves-phase MgZn2 on one side, and the complex 1/1 approximants and quas

Diffraction patterns from apatite-structure compounds Cd5-η/2(TO4)3X1-η with T=P, V and X=Br, I show sheets of diffuse scattering normal to c* at incommensurate l=q (q=1.63 for Cd-V-I apatite and q=1.78 for Cd-P-Br apatite), because the c repeat of the average unit cell is shorter than two X diameters. The equilibrium X..X spacing along c defines the incommensurate periodicity c/q and stoichiometr

Environmental change associated with urbanization is considered one of the major threats to biodiversity. Some species nevertheless seem to thrive in the urban areas, probably associated with selection for phenotypes that match urban habitats. Previous research defined different “copying styles” in distress behavior during the handling of birds. These behaviors vary along a continuum from “proacti

About 25,3 % of the Mozambican population is suffering from undernourishment even though a sufficient amount of food and specifically fruits are produced. Post-harvest losses are estimated to 25 % to 40 % and part of the production is not even harvested due to a short season. A solution has to be found to improve fruit preservation and allow the population to consume what is harvested later. Dryin

Endocrine disrupting chemicals (EDCs) from the environment are associated with reproductive abnormalities (i.e. decreased sperm concentration; increased endometriosis) and alterations of the cardiovascular system (i.e. increased blood pressure and risk of coronary disease). Some phthalates esters have been identified as EDCs, for which inhalation is considered as one of the routes of exposure. How

Purpose: An unprecedented scale of human migration has lead humanitarians to view camps as long-term settlements rather than temporary holding facilities. The purpose of this paper is to increase the understanding of and identify challenges with this proposed new approach to camp design. Design/methodology/approach: Based on the camp design literature, the authors developed an interview guide and

Objective Based on clinical experience gained over many years, the maximal haemostatic effect following administration of local anaesthetics containing epinephrine is generally believed to occur within 10 minutes. Surprisingly, it was found in a recent study, in which bleeding was quantified intraoperatively, that maximal haemostasis did not occur until 30 minutes. If this is indeed the case, the