Filtyp
Osteoblast-osteoclast coordination is critical in the maintenance of skeletal integrity. The modulation of osteoclastogenesis by immature cells of the osteoblastic lineage is mediated through receptor activator of NF kappa B (RANK), its ligand RANKL, and osteoprotegerin (OPG), a natural decoy receptor for RANKL. Here, the expression of OPG and RANKL in primary mouse osteoblastic cultures was inves
Most bacteria are likely to face osmotic challenges, but there is yet much to learn about how such environmental changes affect the architecture of bacterial cells. Here, we report a cell-biological study in model organisms of the genus Streptomyces, which are actinobacteria that grow in a highly polarized fashion to form branching hyphae. The characteristic apical growth of Streptomyces hyphae is
A major challenge in neuroscience is to resolve the connection between gene functionality, neuronal circuits, and behavior. Most, if not all, neuronal circuits of the adult brain contain a glutamatergic component, the nature of which has been difficult to assess because of the vast cellular abundance of glutamate. In this study, we wanted to determine the role of a restricted subpopulation of glut
We examined the efficiency, specificity, and mutational signatures of zinc finger nucleases (ZFNs), transcriptional activator-like effector nucleases (TALENs), and clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 systems designed to target the gene encoding the transcriptional repressor BCL11A, in human K562 cells and human CD34+progenitor cells. ZFNs and TALENs were delivere
The αβ T-cell coreceptor CD4 enhances immune responses more than 1 million-fold in some assays, and yet the affinity of CD4 for its ligand, peptide-major histocompatibility class II (pMHC II) on antigen-presenting cells, is so weak that it was previously unquantifiable. Here, we report that a soluble form of CD4 failed to bind detectably to pMHC II in surface plasmon resonance-based assays, establ
Late Quaternary tree-ring chronologies have been constructed using data collected from subfossil trees preserved under favourable conditions in lake sediments and peat deposits. Tree-ring widths and densities are commonly used for reconstructions of past climate variability. An alternative way of using these data is to explore the replication curves of these chronologies. Here, we make use of prev
The membrane lipid-anchored glypicans (heparan sulfate proteoglycans) are present in both vertebrates and invertebrates and serve as important modulators of growth factors and morphogens during development. Their core proteins are similar and consist of a large N-terminal domain comprising 14 evolutionary conserved cysteines and a C-terminal stalk carrying the heparan sulfate side-chains and the l
Popular Abstract in SwedishMed utgångspunkt i två forskningsfält – strategisk kommunikation och urbanforskning – analyseras och problematiseras Malmös omvandling från arbetarstad till kunskapsstad. Hur har Malmös förändring genomdrivits? Vilka resonemang och föreställningsramar har styrt omvandlingen? Vilka kommunikativa strategier har använts för att projicera den önskvärda (själv)bilden av en kuIncreasingly cities compete for tourist dollars, shoppers, financial investments, know-how and tax-payers by bolstering the cities images as centers of creativity, innovation, knowledge, art, design and so forth. Accelerated and intensified globalization, technological advances, market deregulations,de-industrializations and socio-economic change have urged cities, especially former industrial cit
The use of external providers for the provision of information and communication technology (ICT) in small and medium-sized enterprises (SMEs) is expected to increase. At the end of the 1990s the concept of Application Service Provision (ASP) and Application Service Providers (ASPs) was introduced. This is described as one way for SMEs to provide themselves with software applications. However, it
Despite the spatially homogenous summer temperaturepattern in Fennoscandia, there are large spreadsamong the many existing reconstructions, resulting in anuncertainty in the timing and amplitude of past changes.Also, there has been a general bias towards northernmostFennoscandia. In an attempt to provide a more spatiallycoherent view of summer (June–August, JJA) temperaturevariability within the l
The association between childhood environmental tobacco smoke (ETS) exposure and adult cancer risk is controversial; we examined this relationship in never smokers within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Over an average of 10 years, 8,372 cases of cancer were diagnosed in 112,430 never smokers in EPIC. Childhood ETS was self-reported by participants a
Popular Abstract in Swedish Läkemedel kan sprutas direkt i ytliga blodkärl genom en så kallad perifer venkateter (PVK). Sådan behandling kallas för intravenös. När läkemedel ges intravenöst orsakar de ibland inflammation i den ven där de sprutas in, vilket kan medföra en ytlig blodpropp i kärlet. Denna biverkning kallas ofta för tromboflebit, men i denna avhandling kallas detta tillstånd för infusIntravenous administration of antibiotics is often followed by infusion phlebitis. In this condition are vessel irritation, inflammation and sometimes superficial thrombosis included. In this thesis, the risk for infusion phlebitis for various antibiotics has been evaluated in a clinical study in 550 patients. Various effects of four antibiotics on cultured endothelial cells have also been examine
The influence of hydrophobic modification on solution properties of water-soluble polymers in the semi-dilute regime have been studied. The nonionic ethyl(hydroxyethyl)cellulose (EHEC) and its hydrophobically modified analogue (HM-EHEC) are used as model substances. Interactions between the polymer molecules in solution and a third component are investigated, and in particular the influence of the
Popular Abstract in Swedish Venös trombossjukdom (blodpropp i ben och lunga) förekommer i en frekvens av ca 160 per 100.000 invånare och år i Malmö. Venös trombossjukdom är en av våra vanligaste sjukdomar. Bakgrunden till venös trombossjukdom är mångfacetterad och både ärftliga och förvärvade riskfaktorer bidrar till sjukdomen. Kända riskfaktorer är övervikt, immobilisering (ex gipsbehandling, sla
Affordable and competitive industrial automation is of key importance for small and medium enterprises, in Europe and elsewhere. A key factor is the introduction of new robot automation concepts that ease fast deployment and extend available task repertoire. The Gantry-Tau manipulator is a new robot concept. In contrast to other parallel kinematic manipulators (PKMs), it has a large working range.
Immunoglobulin kappa promoters were collected from mice and man. It was shown that they had homology within but not between subgroups, and the promoters were also conserved between species. The octamer element was found in all promoters, but other sequence elements were conserved within the distinct subgroups. E-boxes were found in most promoters and were usually of the E2A type. A mouse kappa pro
Popular Abstract in Swedish Metan är en växthusgas med stor potential att påverka klimatet på Jorden. Den vattenmättade miljön i våtmarker erbjuder perfekta livsbetingelser för metanproducerande bakterier och detta medför att naturliga våtmarker är den största enskilda källan till metan i atmosfären, även då man räknar med antropogena utsläpp från, till exempel, förbränning av fossila bränslen. MoThe studies presented in Papers I to VI illustrate several different aspects of the impact of vascular plants on methane emissions from northern natural wetlands. The subject has been approached on different scales, ranging from the study of microbial substrates in the vicinity of a single plant root, to an attempt to extrapolate some of the results to the entire northern hemisphere north of 50°N.
