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Electron transfer (ET) of ligninolytic peroxidases was studied in the bioelectrocatalytic reduction reaction of H2O2 at peroxidase-modified graphite electrodes. Specifically, native lignin (LiP) and manganese (MnP) peroxidases secreted by Phanerochaete chrysosporium, as well as a few different recombinant MnP forms were used in the electrochemical studies. The recombinant enzymes included wild-typ

Acute otitis media (AOM) is the most common reason for outpatient antimicrobial therapy. Mixed infections pose a potential problem, since the first-line drug used for the treatment of AOM, amoxicillin, can be neutralized by ß-lactamase-producing pathogens of the upper respiratory tract. To study the effects of a 5-day course of amoxicillin on a mixed middle ear infection, rats were challenged with

The existence of T cells restricted for the MHC I-like molecule CD1 is well established, but the function of these cells is still obscure; one implication is that CD1-dependent T cells regulate autoimmunity. In this study, we investigate their role in experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis, using CD1-deficient mice on a C57BL/6 background. We show t

The extracellular matrix consists of structural macromolecules and other proteins with regulatory functions. An important family of the latter class of molecules found in most tissues is the small leucine-rich repeat proteins (SLRPs). We have previously shown that the SLRP fibromodulin binds directly to C1q and activates the classical pathway of complement. In the present study we further examine

Haemophilus influenzae protein E (PE) is a 16 kDa adhesin that induces a pro-inflammatory immune response in lung epithelial cells. The active epithelial binding region comprising amino acids PE 84-108 also interferes with complement-mediated bacterial killing by capturing vitronectin (Vn) that prevents complement deposition and formation of the membrane attack complex (MAC). Here, the interaction

OBJECTIVE: Smooth muscle cell (SMC) phenotypic modulation, an important component of atherosclerosis progression, is critically regulated by the matrix, with normal components of the healthy SMC matrix limiting modulation and atherosclerosis-associated transitional matrix proteins promoting phenotypic modulation. We sought to determine how collagen IV (which comprises the healthy artery wall) and

OBJECTIVE: Systemic administration of immunotherapeutics often gives rise to severe side effects. A local deposition, using secretory lysosomes of hematopoietic cells as vehicles for delivery, can overcome this problem. In the present study, the validity of this concept was investigated using retroviral transduction of the human soluble tumor necrosis factor-alpha receptor 1 (hsTNFR1) into murine

C4b-binding protein (C4BP) is best known as a potent soluble inhibitor of the classical and lectin pathways of the complement system. This large 500kDa multimeric plasma glycoprotein is expressed mainly in the liver but also in lung and pancreas. It consists of several identical 75kDa α-chains and often also one 40kDa β-chain, both of which are mainly composed of complement control protein (CCP) d

The membrane lipid-anchored glypicans (heparan sulfate proteoglycans) are present in both vertebrates and invertebrates and serve as important modulators of growth factors and morphogens during development. Their core proteins are similar and consist of a large N-terminal domain comprising 14 evolutionary conserved cysteines and a C-terminal stalk carrying the heparan sulfate side-chains and the l

Popular Abstract in SwedishMed utgångspunkt i två forskningsfält – strategisk kommunikation och urbanforskning – analyseras och problematiseras Malmös omvandling från arbetarstad till kunskapsstad. Hur har Malmös förändring genomdrivits? Vilka resonemang och föreställningsramar har styrt omvandlingen? Vilka kommunikativa strategier har använts för att projicera den önskvärda (själv)bilden av en kuIncreasingly cities compete for tourist dollars, shoppers, financial investments, know-how and tax-payers by bolstering the cities images as centers of creativity, innovation, knowledge, art, design and so forth. Accelerated and intensified globalization, technological advances, market deregulations,de-industrializations and socio-economic change have urged cities, especially former industrial cit

The use of external providers for the provision of information and communication technology (ICT) in small and medium-sized enterprises (SMEs) is expected to increase. At the end of the 1990s the concept of Application Service Provision (ASP) and Application Service Providers (ASPs) was introduced. This is described as one way for SMEs to provide themselves with software applications. However, it

Despite the spatially homogenous summer temperaturepattern in Fennoscandia, there are large spreadsamong the many existing reconstructions, resulting in anuncertainty in the timing and amplitude of past changes.Also, there has been a general bias towards northernmostFennoscandia. In an attempt to provide a more spatiallycoherent view of summer (June–August, JJA) temperaturevariability within the l

The association between childhood environmental tobacco smoke (ETS) exposure and adult cancer risk is controversial; we examined this relationship in never smokers within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Over an average of 10 years, 8,372 cases of cancer were diagnosed in 112,430 never smokers in EPIC. Childhood ETS was self-reported by participants a

Till skillnad från effekter förknippat med övergödning och marin plast, är få medvetna om den negativa miljöpåverkan sandmuddring kan ha på de marina ekosystemen. Sandmuddring ger stora förluster i livsmiljö, förändringar i salthalt och ökad grumlighet vilket utgör ett potentiellt hot mot ett stort antal marina och bräckvatten arter. Ännu värre är det faktum att få människor vet att sandutvinning Unlike effects associated with eutrophication and marine plastics, few are aware of the negative environmental impacts sand dredging can have on marine ecosystems. Major habitat losses, changes in salinity and increased turbidity impose a potential threat to a large variety of marine and brackish species. Even worse is the fact that few people know that sand extraction currently is taking place wi

Syfte: Syftet med vår studie är att beskriva och analysera utformning av organisation och styrning av akutkliniker. Det är också att undersöka huruvida specifika arbetssätt utmärker sig och utifrån detta skapa ett underlag för framtida diskussion rörande organisation och styrning av akutsjukvård. Metod: Uppsatsens metod grundar sig i en kvalitativ undersökningsdesign där multipla fallstudier anväPurpose: The purpose of this thesis is to describe and analyze the organization of and control tools used at emergency clinics. Futhermore it aims explore whether any methods are better than others to ease the patients’ process through the organization and create a basis for further discussion. Methodology: The thesis method is based on a qualitative research design where multiple case studies ha

In forest biomass estimations, three dimensional (3D) canopy structure data derived from images captured by unmanned aerial vehicles (UAVs), also known as drones, has shown potential due to the flexibility and cost efficiency of the method. However, little research has been done for its applicability in bioenergy forest. In this study, a method was developed with the purpose of remotely estimating

During the second half of August and the first part of September 2017, I radiotracked several European nightjars (Caprimulgus europaeus) around the Stensoffa area in Southern Sweden. Several locations were taken for each bird each night, including diurnal roost and nocturnal points composed by flying and resting behaviours. Being a long-distance migrator already on the way south during autumn migr