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TGFα is a member of the epidermal growth factor (EGF) family and is one of the ligands for the EGF- receptor. The precursor of TGFα, pro-TGFα, is a transmembrane protein. The aim of this project has been to establish a model for studies of pro-TGFα effects on EGF receptor signalling, in particular through Gab1, a docking protein involved in PI3K/Akt signalling pathway. The experiments in this thes
Changes in rainfall patterns driven by climate change affect the transport of dissolved organic matter (DOM) and nutrients through runoff to freshwater systems. This presents challenges for drinking water providers. DOM, which is a heterogeneous mix of organic molecules, serves as a critical precursor for disinfection by-products (DBPs) which are associated with adverse health effects. Predicting
To resolve the various types of biological ice nuclei (IN) with atmospheric models, an extension of the empirical parameterization (EP) is proposed to predict the active IN from multiple groups of primary biological aerosol particles (PBAPs). Our approach is to utilize coincident observations of PBAP sizes, concentrations, biological composition, and ice nucleating ability. The parameterization or
Extracellular High Mobility Group Box 1 (HMGB1) has been associated with acute and chronic inflammatory conditions. However, little is known about HMGB1 in necrotizing bacterial infections. We hypothesized that the local HMGB1 response is excessive in severe soft tissue infections (STIs), which are characterized by necrosis and hyperinflammation. To explore this, tissue biopsies were collected fro
Pyocyanin, a redox-active secondary metabolite produced by Pseudomonas aeruginosa, serves as a crucial virulence factor. Detection and quantification of pyocyanin can aid early diagnosis of infection. A selective and sensitive molecularly imprinted electrochemical sensor was constructed by using a green polymerization technique to deposit an ultrathin polydopamine film on an electrode modified wit
The input of strontium from aquatic resources in an omnivorous diet has been researched to a lesser degree than that of terrestrial sources, which, in specific sociocultural settings, complicates the study of provenance and mobility. To address this lack of research and to investigate forager mobility in an archipelago environment, where access to terrestrial resources was limited and earlier stud
During the last decades a striking decline has been observed for wild bees throughout central and north-western Europe, including Sweden. in an area of 64 km' in the parish of Stenbrohult, southern Smaland Andrena hattorfiana, Andrena humilis, Nomada armata and Panurgus hanksianus were studied (in Sweden red-listed as VU, EN, EN and VU). We present occurrence patterns in relation to habitat types
Popular Abstract in Swedish Bakgrund När en kärlskada uppstår är det viktigt att blödningen snabbt kan stoppas. Detta åstadkomms genom att koagulationssystemet bildar en blodpropp vid skadestället. Von Willebrand faktorn (VWF) är ett stort protein som cirkulerar i blodet. Detta protein ingår, tillsammans med blodplättarna, i koagulationssystemets första fas. När ett kärl skadas binder VWF (som se
The gene responsible for X-linked agammaglobulinemia (XLA) has been recently identified to code for a cytoplasmic tyrosine kinase (Bruton's agammaglobulinemia tyrosine kinase, BTK), required for normal B cell development. BTK, like many other cytoplasmic tyrosine kinases, contains Src homology domains (SH2 and SH3), and catalytic kinase domain. SH3 domains are important for the targeting of signal
The oxyntic mucosa of the mammalian stomach is rich in endocrine cells, such as ECL cells, A-like cells, somatostatin cells, D1/P cells and, in some species, enterochromaffin cells. The various endocrine cell types can be distinguished on the basis of their characteristic cytoplasmic granules and vesicles. The ECL cells contain numerous large secretory vesicles and relatively few, small electron-d
Early peat surveys demonstrated the potential to detect Holocene climatic changes in southern Sweden through analysis of the degree of decomposition of Sphagnum peat and motivated systematic collection of peat-strati graphic information during subsequent geological mappings in central and northern Sweden. The resulting (published and unpublished) data was compiled and reanalysed, taking into accou
Background: Sentinel lymph node biopsy is an established staging method in early breast cancer. After a negative biopsy, most institutions will not perform a completion axillary dissection. The present study reports the current axillary recurrence (AR) rate, overall and disease-free survival in the Swedish Multicenter Cohort Study. Methods: From 3534 patients with primary breast cancer <= 3 cm pro
BACKGROUND: It is widely accepted that DNA double-strand breaks (DSBs) and their misrepair in stem cells are critical events in the multistage origination-of various leukemias and tumors, including gliomas. OBJECTIVES: We studied whether microwaves from mobile telephones of the Global System for Mobile Communication (GSM) and the Universal Global Telecommunications System (UMTS) induce DSBs or aff
The effect of body size on spatial resource competition and reproductive isolation was examined in a sister species pair of subtidal triplefin fishes (F. Tripterygiidae) in New Zealand. Ruanoho decemdigitatus and Ruanoho whero have overlapping sympatric distributions and differ in body size, attaining a total length of 12 cm and 9 cm, respectively. R. decemdigitatus was most commonly found in shel
Bracon hebetor is a larval ectoparasitoid that utilizes several pests belonging to the family Pyralidae (Lepidoptera) as hosts. In the present study, we analyzed the kairomonal response of this wasp to the male-produced sex pheromone of a host, the greater wax moth Galleria mellonella, an economically important pest of honeybees, Apis mellifera. Coupled gas chromatography-electroantennographic det
Aim: Hemoglobin (Hb) becomes toxic when released from the erythrocyte. The acute phase protein haptoglobin (Hp) binds avidly to Hb and decreases oxidative damage to Hb itself and to the surrounding proteins and lipids. However, the molecular mechanism underpinning Hp protection is to date unclear. The aim of this study was to use electron paramagnetic resonance (EPR) spectroscopy, stopped flow opt
Assessment of clinical risk factors for haemorrhagic complications in patients undergoing intra-arterial thrombolysis for lower limb ischaemia. Retrospective reviews of consecutive patients subjected to intra-arterial thrombolysis due to lower limb ischemia at the Vascular Center, Malmö University Hospital, during a 5-year period from 2001 to 2005. Two hundred and twenty intra-arterial thrombolyti
