Sökresultat

We have seen that protein kinase Calpha (PKCalpha) is transiently translocated to the plasma membrane by carbachol stimulation of neuroblastoma cells. This is induced by the Ca2+ increase, and PKCalpha does not respond to diacylglycerol (DAG). The unresponsiveness is dependent on structures in the catalytic domain of PKCalpha. This study was designed to investigate if and how the kinase activity a

Questions: (1) Does soil acidification in calcareous sandy grasslands lead to loss of plant diversity? (2) What is the relationship between the soil content of lime and the plant availability of mineral nitrogen (N) and phosphorus (P) in sandy grasslands? Location: Sandy glaciofluvial deposits in south-eastern Sweden covered by xeric sand calcareous grasslands (EU habitat directive 6120). Methods:

Time to blood culture positivity (TTP) is an indirect measure of bacterial concentration in blood. A short TTP has been linked to the presence of infective endocarditis (IE) and to poor prognosis in Staphylococcus aureus bacteremia. We analyze factors influencing TTP in bacteremia with Enterococcus faecalis. This retrospective observational study of medical records included adults diagnosed with m

The present work addressed the hypothesis that NG2/CSPG4, CD146/MCAM, and VAP1/AOC3 are target genes of myocardin-related transcription factors (MRTFs: myocardin/MYOCD, MRTF-A/MKL1, MRTF-B/MKL2) and serum response factor (SRF). Using a bioinformatics approach, we found that CSPG4, MCAM, and AOC3 correlate with MYOCD, MRTF-A/MKL1, and SRF across human tissues. No other transcription factor correlat

Background: Indications for negative-pressure wound therapy (NPWT) in vascular surgical patients are expanding. The aim of this review was to outline the evidence for NPWT on open and closed wounds. Methods: A PubMed, EMBASE and Cochrane Library search from 2007 to June 2016 was performed combining the medical subject headings terms 'wound infection', 'abdominal aortic aneurysm (AAA)', 'fasciotomy

Deterioration of concrete structures is a worldwide problem. Environmental exposure is known to affect concrete strength in structures. While moisture affects rebound values by lowering them, carbonation does the opposite. The aim of the study was to determine the in-situ concrete strength of three bridge elements, namely, pier, abutment and deck and evaluate the environmental conditions such as m

The human genome contains at least 35 genes that encode Golgi sulfotransferases that function in the secretory pathway, where they are involved in decorating glycosaminoglycans, glycolipids, and glycoproteins with sulfate groups. Although a number of important interactions by proteins such as selectins, galectins, and sialic acid-binding immunoglobulin-like lectins are thought to mainly rely on su

Water demand growth coupled with its high spatial-temporal mismatch of water resources will lead to an increasing water scarcity worldwide. In order to investigate a robust long-term water stress for ecosystems and regions across China, the improved maximum entropy production (MEP) method was utilized to obtain a reliable evapotranspiration (ET) product during 1982–2015. Afterwards four water stre

Activation of the Met receptor tyrosine kinase, either by its ligand, hepatocyte growth factor (HGF), or via ligand-independent mechanisms, such as MET amplification or receptor overexpression, has been implicated in driving tumor proliferation, metastasis, and resistance to therapy. Clinical development of Met-targeted antibodies has been challenging, however, as bivalent antibodies exhibit agoni

BACKGROUND: Pseudomyxoma peritonei (PMP) is a rare disease with an estimated incidence of 1 per million per year, and is thought to originate usually from an appendiceal mucinous epithelial neoplasm. However it is not known exactly how often these neoplasms lead to PMP. The aim of this study is to investigate the incidence of both lesions and their relation.METHODS: The nationwide pathology databa

The amount of wind turbines in Sweden has more than doubled in the last five years. Wind turbines can affect birds directly, by causing fatalities and indirectly, through habitat destruction, disturbance and barrier effects resulting from turbine construction and operation. To increase understanding of how this rapidly expanding form of energy harvesting affects avian communities in Sweden large,

Pollinators are important for both the agricultural landscape and natural areas, but currently many pollinator groups are declining. Pollinators have a strong relationship with plants, which humans long have benefited from. Nowadays, 35 % percent of the human food production somehow relies on animal pollination. Therefore, unravel the details about crop pollination and its relationship to differen

The floating population, also known as rural-urban immigrants, is a typical type of domestic migration appearing in the process of urbanization in contemporary China. Due to the policy restrictions, the Floating population is in a disadvantageous position and lacks social security. Though the ultimate goal for many domestic immigrants is to transform into urban residents, the biggest challenge t

Coastal engineering activities during the past five decades have resulted in considerable shoreline change along the northern coast of Sinai Peninsula. In the west of El Arish Power Plant, sediment accretion has reached the tip of the breakwater of the cooling water intake basin necessitating extensive dredging inside the basin. In the east of El Arish Harbor, the shoreline is continuously retreat

In this essay I have tried to come close to a probable answer to the following question: Is there a risk that the trust between the Swedish public and the Swedish medical services staff, including the doctors, will be severely damaged if euthanasia is legalized in Sweden. In order to try to answer that question, and some other relevant questions that has corresponding interest in the context that

This study presents the formulation of planning guidelines to apply by the responsible entity for municipal solid waste management (IMAUBAR) in Iribarren Municipality, Venezuela, with the aim of complying with the recent legislative instrument passed in December 2010, the Law of Integrated Management of Garbage. An overview of the Latin American Region solid waste management planning documents was