Filtyp
Objectives: Polyamines are organic polycations playing an essential role in cell proliferation and differentiation, as well as in cell contractility, migration and apoptosis. These processes are known to contribute to restenosis, a pathophysiological process often occurring in patients submitted to revascularization procedures. We aimed to test the effect of alpha-difluoromethylornithine (DFMO), a
Phthalates which are widely used, are ubiquitous in the environment and in some human tissues. It is generally accepted that phthalates exert their toxic action by inhibiting Leydig cell synthesis of testosterone, but in vitro studies have also shown anti-androgenic effects at the receptor level. Some cross-sectional studies have shown inverse associations between urinary levels of phthalates and
Resolving the spatial and temporal dynamics of gross primary productivity (GPP) of terrestrial ecosystems across different scales remains a challenge. Remote sensing is regarded as the solution to upscale point observations conducted at the ecosystem level, using the eddy covariance (EC) technique, to the landscape and global levels. In addition to traditional vegetation indices, the photochemical
Objective: To assess exercise induced analgesia (EIA) and pain sensitivity in hip and knee osteoarthritis (OA) and to study the effects of neuromuscular exercise and surgery on these parameters. Design: The dataset consisted of knee (n = 66) and hip (n = 47) OA patients assigned for total joint replacement at Lund University Hospital undergoing pre-operative neuromuscular exercise and 43 matched c
A mathematical model of spit growth and barrier elongation adjacent to an inlet (of arbitrary width), supplied by sediment coming from longshore sediment transport, was developed based on the spit growth model proposed by Kraus (1999). The fundamental governing equation is the conservation equation for sand, where the width of the spit is assumed constant during growth. The portion of the longshor
Characteristics of small, intermediate and large ions and nanometre particles, and the influences of environmental conditions and local topography on the interactions of these ions and particles in the size range of 3.85-47.8 nm diameter are studied during new particle formation (NPF) events observed at Pune, India from 20 March to 23 May 2012. During the NPF events, the formation rate of 5 nm par
In unsparing efforts to find the hidden primaries, second primary cancers (SPCs) unrelated to cancer of unknown primary (CUP) are found. The detection rates of SPCs after CUP can be considered as measures for the effectiveness of modern diagnostic techniques in finding tumors. We aimed to compare the rates of specific SPCs found after the work-up of CUP and the more sign/symptom-directed diagnosti
We present a comparison of feather stable isotope (C-13, N-15) patterns representing the habitat and diet conditions for two subspecies of willow warblers Phylloscopus trochilus that breed in parapatry, but winter in different regions of sub-Saharan Africa. Previous analyses have shown that on average winter moulted innermost primaries (P1) show subspecific differences in N-15 values, although ind
The antioxidant quercetin was extracted from yellow onion waste and converted to its aglycone form by a combination of subcritical water extraction and enzymatic hydrolysis. The hydrolytic step was catalysed by a double residue (N221S, P342L) mutant of the thermostable beta-glucosidase (TnBgl1A), isolated from the thermophile Thermotoga neapolitana and cloned and produced in E. coli. The activity
The role of the mitochondrial protein frataxin in iron storage and detoxification, iron delivery to iron-sulfur cluster biosynthesis, heme biosynthesis and aconitase repair has been extensively studied during the last decade. However, still no general consensus exists on the details of the mechanism of frataxin function and oligomerization. Here, using small-angle X-ray scattering (SAXS) and X-ray
Evaluating potentially analgesic effects of drugs and various treatments is critically dependent on valid animal models of pain. Since primary somatosensory (SI) cortex is likely to play an important role in processing sensory aspects of pain, we here assess whether monitoring SI cortex nociceptive C fibre evoked potentials can provide useful information about central changes related to hyperalges
Cancer of unknown primary (CUP) is diagnosed at the metastatic stage and despite extensive diagnostic work-up the primary tumor often remains unidentified. Limited population-based survival data are available for metastatic location and none are available that link the location with the cause of death, which might give clues about the tissue of origin. A total of 9,306 CUP patients with extranodal
I varje samhälle har konsumenter en avgörande roll för att klimatanpassade varor och tjänster köps, används och till sist källsorteras. En alldeles övervägande andel svenskar har under flera decennier visat sig vara i hög grad miljömedvetna. Klimatförändringar såsom global uppvärmning och ett växande ozonhål har varit bland de aspekter på klimatförändringar man oroat sig mest för. Kunskap om miljö
Popular Abstract in Swedish Jag har i denna avhandling studerat konflikter mellan könen hos en art som är fakultativt polygyn. Hanar har högre reproduktionsframgång ju fler honor de kan attrahera medan honor som parar sig med polygyna hanar har sämre reproduktionsframgång än monogama honor. Detta skapar en konflikt mellan hane och hona över parningssystem och jag har studerat denna konflikt hos stIn this thesis, I have investigated conflicts of interest in the facultatively polygynous European starling (Sturnus vulgaris) with a focus on female reproductive strategies. The extent to which males provided parental care was a key issue in understanding the mating system of the starling. The amount of male parental care affected the quality of offspring. Polygynous males did not invest more in
Att kalla vissa historiska ledargestalter hos de kanadensiska mi'kmaqindianerna "schamaner" är inte oproblematiskt. De historiska texterna från 1600-talet nedtecknades av författare som inte behärskade mi'kmaqspråket, inte var intresserade av ursprungskulturen och dessutom skrev sina berättelser i syfte att visa missionens förträfflighet. Frågan är om det är fruktbart att applicera termen på de få
Popular Abstract in Swedish Trots att kroppen skyddas av ett hudlager på utsidan och av epitelceller i kroppens inre organ utsätts vi hela tiden för infektioner. När en vävnad blir infekterad börjar cellerna utsöndra inflammatoriska mediatorer som bland annat orsakar svullnad och rodnad. En inflammation kan också orsakas av till exempel slag eller brännskador. De inflammatoriska mediatorerna signaThis thesis describes early inflammatory responses involving interactions between leukocytes and the endothelial lining of the blood vessel wall. An adhesion molecule, E-selectin, which is upregulated on interleukin-1 activated endothelium, was found to mediate rolling between leukocytes and endothelial cells in vivo. Immunohistochemistry revealed that E-selectin was preferentially expressed in ve
This thesis presents development of new analytical methods using antibodies and molecularly imprinted polymers (MIPs) in binding assays: 1) The high specificity of antibodies and the wide variety of efficient labels make immunoassay one of the most popular analytical techniques today. Enzyme-linked immunosorbent assay (ELISA) is most widely used, since the enzyme label can be used as a catalyst t
The subject of this thesis is complement inhibitor C4b-binding protein (C4BP), on which we have performed both structural and functional studies. Complement is part of the innate immune defence and eliminates microbes, solubilises immune complexes and is involved in the clearance of apoptotic cells. The actions of the complement system must be carefully controlled by proteins such as C4BP to avoid
