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We tracked three juvenile and 14 adult Marsh Harriers Circus aeruginosus from southern Sweden via satellite to investigate migration strategies. Four individuals were tracked for at least two years. All three juveniles and four of the adults made west-oriented pre-migratory movements well before the onset of autumn migration, and trans-Saharan migrants visited post-migratory stopover areas in trop

Rational drug design is predicated on knowledge of the three-dimensional structure of the protein-ligand complex and the thermodynamics of ligand binding. Despite the fundamental importance of both enthalpy and entropy in driving ligand binding, the role of conformational entropy is rarely addressed in drug design. In this work, we have probed the conformational entropy and its relative contributi

The Palaeocene arctic supported a vegetation type quite distinct from the tundra and polar desert of today. Here we demonstrate, through the palynological record, the structure of this extinct vegetation and its dynamics over this period. The Late Palaeocene coal-bearing units of the Sagwon Bluffs on Alaska's North Slope (present latitude 69 degrees N) are predominantly fine-grained, non-marine an

When dealing with large-scale environmental contamination, as following the Chernobyl accident, changed land use such that the products of the land are radiologically acceptable and sustain an economic return from the land is a potentially sustainable remediation option. In this paper, willow short rotation coppice (SRC) is evaluated on radiological, technical and economic grounds for W. European

Fibroblast-mediated collagen gel contraction depends on collagen-binding ss1 integrins. Perturbation of these integrins reveals an alternative contraction process that is integrin aVss3-dependent and platelet-derived growth factor (PDGF) BB-stimulated. Connective tissue cells actively control interstitial fluid pressure (IFP) and inflammation-induced lowering of IFP provides a driving force for ed

Glioblastoma multiforme is the most common malignant primary brain tumor and also one of the most therapy-resistant tumors. Because of the dismal prognosis, various therapies modulating the immune system have been developed in experimental models. Previously, we have shown a 37-70% cure in a rat glioma model where rats were peripherally immunized with tumor cells producing IFN. On the basis of the

Transcriptional factors of the GntR family regulate numerous physiological and morphological processes in response to the nutrient state of bacterial cells. The number of GntR transcriptional factors in genomes of soil-dwelling actinomycetes is one of the highest among bacteria, reflecting both the large size of their chromosomes and the complex ecological niche that they occupy. However, very lit

Light sensors are increasingly used to monitor vegetation growing status by measuring reflectance or transmittance in multispectral or photosynthetically active radiation (PAR) bands. The measurements are then used to estimate vegetation indices or the fraction of absorbed PAR (FPAR) in a continuous and long-term manner and to serve as inputs to environmental monitoring and calibration/validation

Heteroclitic monoclonal antibodies are characterized by the ability to bind multiple epitopes with little or no similarity. Such antibodies have been reported earlier, but insight into to the molecular basis of this propensity is limited. Here we report that the KIM185 antibody to human CD18 reacts with the plasma protein C4b-binding protein (C4BP). This was revealed during affinity purification p

Background: S100A9 has been shown to be important for the function of so called Myeloid Derived Suppressor Cells (MDSC). Cells with a similar phenotype are also involved in pro-inflammatory processes, and we therefore wanted to investigate the gene expression and function of these cells in animals that were either subjected to chronic inflammation, or inoculated with tumors. Methods: CD11b(+)Ly6C(

Waxing and waning ice sheets and changing sea levels have been interpreted from the Quaternary stratigraphic record at Leinstranda, Broggerhalvoya in NW Svalbard. We have identified seven high relative sea-level events, related to glacio-isostatic loading, and separated by at least four glacial events. To establish a chronology for the high sea-level events (interstadials and interglacials) and th

Popular Abstract in Swedish Vid genterapi för man in nya gener i en individs celler. Detta kan göras med hjälp av modifierade virus. Dessa virus kan föra in den nya genen, den såkallade transgenen, in i värdcellen men inte bilda nya viruspartiklar. I många fall är det viktigt att begränsa i vilka celler som transgenen uttrycks, då det producerade proteinet kan ge bieffekter i andra celltyper. Det Gene therapy is a promising therapeutic tool for many diseases of the CNS. Lentiviral vectors are particularly attractive since this vector type can transduce both dividing and non-dividing cells, have a relatively large cloning capacity, can sustain long-term transgene expression and have low immunogenicity. The specificity of the vector is however important to avoid potential off-target effects

Background: Mild to moderate cognitive impairment is common amongst long-term survivors of cardiac arrest. In the Target Temperature Management trial (TTM-trial) comatose survivors were randomized to 33 degrees C or 36 degrees C temperature control for 24 hours after cardiac arrest and the effects on survival and neurological outcome assessed. This protocol describes a sub-study of the TTM-trial i

Protein dynamics on the micro- to millisecond time scale is increasingly found to be critical for biological function, as demonstrated by numerous NMR relaxation dispersion studies. Methyl groups are excellent probes of protein interactions and dynamics because of their favorable NMR relaxation properties, which lead to sharp signals in the H-1 and C-13 NMR spectra. Out of the six different methyl

The difficulty of obtaining accurate information about the canopy structure is a current limitation towards higher accuracy in numerical predictions of the wind field in forested terrain. The canopy structure in computational fluid dynamics is specified through the frontal area density and this information is required for each grid point in the three-dimensional computational domain. By using raw

Serglycin is a proteoglycan expressed by some malignant cells. It promotes metastasis and protects some tumor cells from complement system attack. In the present study, we show for the first time the in situ expression of serglycin by breast cancer cells by immunohistochemistry in patients' material. Moreover, we demonstrate high expression and constitutive secretion of serglycin in the aggressive

Nitrogen (N) fixation in the feather moss-cyanobacteria association represents a major N source in boreal forests which experience low levels of N deposition; however, little is known about the effects of anthropogenic N inputs on the rate of fixation of atmospheric N-2 in mosses and the succeeding effects on soil nutrient concentrations and microbial community composition. We collected soil sampl

ESA's Soil Moisture and Ocean Salinity (SMOS) mission has been designed to extend our knowledge of the Earth's water cycle. Soil Moisture and Ocean Salinity records brightness temperatures at the L-band, which over land are sensitive to soil and vegetation parameters. On the basis of these measurements, soil moisture and vegetation opacity data sets have been derived operationally since 2009 for a