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Introduction: Assay discrepancy in factor VIII activity between the one-stage and the chromogenic assays has been described in approximately one third of patients with non-severe haemophilia A. Whether assay discrepancy may also occur in patients with haemophilia B remains unknown. Aim: This study compared the results from the one-stage and the chromogenic assays in patients with haemophilia B. Me
Background: High levels of blood glucose are thought to be associated with colorectal cancer (CRC) and hyperinsulinemia, an interstage in the development of CRC. The purpose of this study was to examine associations between incident CRC and blood glucose; plasma insulin; and the homeostasis model assessment for insulin resistance (HOMA2-IR), respectively, and to determine whether these association
Popular Abstract in Swedish Många växtarter kan inte kolonisera kalkjordar och det är stora skillnader i artsammansättningen mellan kalkjordar och närliggande surare jordar. Detta beteende kallas ofta för kalkskyende och tycks orsakas av en oförmåga hos dessa växtarter att lösa och ta upp fosfat och järn ur kalkjordar. Kalkjordar innehåller mycket låga halter av järn och fosfat löst i marklösninge
This thesis examines the effect of water quality, habitat and species interactions on the occurrence and abundance of stream fishes in southern Sweden. I found that improvements in water quality between the 1960s and 1990s have led to recolonization of streams by brown trout (Salmo trutta L.), stone loach (Barbatula barbatula L.) and eel (Anguilla anguilla L.). The response was greatest for brown
BACKGROUND: According to the World Health Organization (WHO) the cost of adverse drug reactions (ADRs) in the general population is high and under-reporting by health professionals is a well-recognized problem. Another way to increase ADR reporting is to let the consumers themselves report directly to the authorities. In Sweden it is mandatory for prescribers to report serious ADRs to the Medical
ERP systems became popular with large organizations in the 1990s. In the 21st Century, these products were expanded by addition of supply chain management (SCM) and customer relationship management (CRM), as well as access through the Web, creating the ERP II concept. Efforts to increase the market led vendors to serve not only large organizations, but also focus more on small-to-medium sized ente
In the aftermath of the nuclear weapons testing and as compared with agriculture, the forest industry has received relatively little attention in spite of its large-scale use of radiocesium- contaminated wood and water. After the Chernobyl nuclear power plant accident in 1986, numerous studies of the forest environment have been conducted with respect to radionuclide transfer through the forest ec
Popular Abstract in Swedish Alla celler behöver energi och de skaffar den på olika sätt, t. ex. från oxidering av mat eller från solljus. Adenosin trifosfat (ATP), som kallas för cellens energivaluta, kan dock inte syntetiseras direkt från mat eller ljus. Nästan alla organismer utnyttjar proteinkomplex i form av en andningskedja som sitter i membranet för att alstra en proton potential. Det kan liComplex I is the mitochondrial enzyme complex that oxidizes NADH produced in the citric acid cycle and reduces quinone in the membrane, coupled to proton pumping out of the mitochondrial matrix, creating a membrane potential. This process generates about 40% of the energy used by living organisms. High-resolution structures of complex I recently became available, but the molecular mechanism behind
We have studied the diffusive mobility of hydrogen molecules confined in different size cages in clathrate hydrates. In clathrate hydrate H2 molecules are effectively stored by confinement in two different size cages of the nano-porous host structure with accessible volumes of about 0.50 and 0.67 nm diameters, respectively. For the processes of sorption and desorption of the stored hydrogen the di
Increasing evidence supports the benefit of identifying BRCA1 and BRCA2 germline mutations in early breast cancer. Selection of patients for genetic testing is based on defined criteria taking individual and family history related factors into account. It is important to make a distinction between efficacy and effectiveness of BRCA testing criteria. Efficacy can be defined as the performance under
The Benguela Upwelling System (BUS), located between 30 and 20°S, is one of the fundamental high-productivity systems of the world ocean. The BUS has previously been studied in terms of primary productivity and ecology over glacial-interglacial timescales; however, the response and coupling with the benthic environment have received little attention. Here, for the first time, we present a high-res
The relation between use of sunscreens, different host factors and malignant melanoma was investigated in a population-based, matched case-control study of malignant melanoma in the South Swedish Health Care Region, which has the highest risk for melanoma in Sweden, between 1 July 1988 and 30 June 1990. In total, 400 melanoma patients and 640 healthy controls aged 15-75 years answered a comprehens
Background-The correlation of null alleles with human phenotypes can provide insight into gene function in humans. In individuals of African ancestry, we set out to identify null and damaging missense variants, and test these variants for association with a range of cardiovascular phenotypes. Methods and Results-We performed whole-exome sequencing in 3223 black individuals from the Jackson Heart S
BACKGROUND: Transforming growth factor-β1 (TGF-β1) is a potent regulator of cell growth and differentiation. TGF-β1 has been shown to be a key player in tissue remodeling processes in a number of disease states by inducing expression of extracellular matrix proteins. In this study a quantitative proteomic analysis was undertaken to investigate if TGF-β1 contributes to tissue remodeling by mediatin
Using the combination of high resolution core level spectroscopy and density functional theory we present adetailed spectroscopic study for all clean and hydrogen covered phases of Ir(100). The results are complementedby an investigation of the hydrogen desorption process from various phases using temperature programmeddesorption spectroscopy and scanning tunneling microscopy. In total, all experi
Carbon dioxide (CO 2) is the most important anthropogenic greenhouse gas contributing to about half of the total anthropogenic change in the Earth's radiation budget. And about half of the anthropogenic CO2 emissions stay in the atmosphere, the remainder is taken up by the biosphere. It is of paramount importance to better understand CO2 sources and sinks and their spatio-temporal distribution. In
