Sökresultat

In order to elucidate the influence of nicotine smoking on bone mass in elderly women, bone mass was cross-sectionally assessed by dual energy X-ray absorptiometry (DXA) in total body, hip and lumbar spine, as well as with ultrasound of calcaneus and phalanges of the hand. Subjects were 1,042, 75-year old women, recruited on a population basis (Osteoporosis Prospective Risk Assessment (OPRA) study

We have previously shown that porcine aortic endothelial cells expressing the Y934F platelet-derived growth factor (PDGF) beta-receptor mutant respond to PDGF-BB in a chemotaxis assay at about 100-fold lower concentration than do wild-type PDGF beta-receptor-expressing cells (Hansen, K., Johnell, M., Siegbahn, A. , Rorsman, C., Engstrom, U., Wernstedt, C., Heldin, C.-H., and Ronnstrand, L. (1996)

The idea that noncrop habitat enhances pest control and represents a win–win opportunity to conserve biodiversity and bolster yields has emerged as an agroecological paradigm. However, while noncrop habitat in landscapes surrounding farms sometimes benefits pest predators, natural enemy responses remain heterogeneous across studies and effects on pests are inconclusive. The observed heterogeneity

As a part of a democratic demand for transparency in urban development processes it is important that design professionals hold the ability to scrutinize their own work process, and at certain stages let go of predefined ideas of future realities. The work of Sandra Kopljar’s dissertation revolves around how design professionals perceive options for design in such situations. A basic assumption th

The objective of this study was to investigate whether the superantigen staphylococcal enterotoxin A (SEA), which binds to HLA class II and T-cell receptor Vβ chains, can direct cytotoxic T cells to lyse cytokine-stimulated endothelial cells (EC). In addition, we wanted to determine whether SEA- primed cytotoxic T cells could be targeted to EC surface molecules as a means of a novel cancer immunot

Background Integrating mental health with general medical care can increase access to mental health services, but requires helping generalists acquire a range of unfamiliar knowledge and master potentially complex diagnostic and treatment processes.Method We describe a model for integrating complex specialty care with generalist/primary care, using as an illustration the integration of mental heal

Ever since its introduction 40 years ago l-3,4-dihydroxyphenylalanine (l-DOPA) therapy has retained its role as the leading standard medication for patients with Parkinson's disease. With time, however, the shortcomings of oral l-DOPA treatment have become apparent, particularly the motor fluctuations and troublesome dyskinetic side effects. These side effects, which are caused by the excessive sw

OBJECTIVE: To investigate the risk of cancer in patients with biopsy-proven giant cell arteritis (GCA) from a defined population in southern Sweden.METHODS: The study cohort consisted of 830 patients (mean age at GCA diagnosis was 76.3 years, 74 % women) diagnosed with biopsy-proven GCA between 1997 and 2010. Temporal artery biopsy results were retrieved from a regional database and reviewed to as

We have previously shown that exposure of DDT1 MF-2 smooth muscle cells to the agonist bradykinin (BK) resuits in a rapid B2 kinin receptor-mediated internalization of BK followed by degradation of the intracellular BK [Munoz, C. M., and Leeb-Lundberg, L. M. F. (1992) J. Biol. Chem. 267, 303-309]. Here, we show that BK internalization is paralleled by sequestration of the occupied B2 receptors. Se

The concept of the 1H-NMR window has been developed and examined through a comparative study of NOESY spectra of a self-complementary Dickerson's dodecamer (I) [S'd^C^CGWA^T^T^Ci4GisCi6G) 23'] ) a self-complementary 20-mer (II) [(5d(1 C2G3C4G5C6G7C8G9A1 ˚A11T12T13C14G15C16G17C- 18G19C20G)23'] in which the core part consists of the same Dickerson's dodecamer sequence with the flanking CGCG residues

The degree of trophic specialization determines the ability of predators to cope with changing foraging conditions, but in predators that prey on hundreds of species it is challenging to assess, especially when prey identity varies among predator individuals and across space and time. Here, we test the hypothesis that a bat species foraging on flying insects like moths will show ample flexibility

Aims: A high intake of salt raises blood pressure and the risk of cardiovascular disease. Previous studies have reported on the association between salt intake and carotid stenosis, but the association with coronary atherosclerosis has not been reported. Therefore, this project aimed at studying the association between salt intake and both carotid and coronary atherosclerosis in a contemporary com

Neurotensin (NT) is a small protein implicated in the regulation of energy balance which acts as both a neurotransmitter in the central nervous system and as a gastrointestinal peptide. In the gut, NT is secreted after fat ingestion and promotes the absorption of fatty acids. The circulating levels of its precursor, pro-NT, predicts the presence and development of metabolic and cardiovascular dise

Biological aerosol particles affect human health, are essential for microbial and gene dispersal, and have been proposed as important agents for atmospheric processes. However, the abundance and size distributions of atmospheric biological particles are largely unknown. In this study we used a laser-induced fluorescence instrument to measure fluorescent biological aerosol particle (FBAP) concentra

Right before northern hemisphere’s summer shifts to autumn small insect-eatingbirds start lengthy journeys to tropical regions. It is well established that temporarylack food and annual changes in weather are the ultimate reasons for this behavior.On a proximal level however, the process is poorly understood. Yet crosscontinental bird migration is a widespread phenomenon that has evolved severalti

4-1BB (CD137) is an activation-induced costimulatory receptor that regulates immune responses of activated CD8 T and natural killer cells, by enhancing proliferation, survival, cytolytic activity, and IFNγ production. The ability to induce potent antitumor activity by stimulating 4-1BB on tumor-specific cytotoxic T cells makes 4-1BB an attractive target for designing novel immuno-oncology therapeu

The accurate estimation of soil carbon (C) pool and fluxes is a prerequisite to better understand the terrestrial C feedback to climate change. However, recent studies showed considerable uncertainties in soil C estimates. To provide a reliable C estimate in the grasslands of the Qinghai-Tibet Plateau (QTP), we calibrated key parameters in a process-based ecosystem model (the CENTURY model) throug