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The sperm whale (Physeter macrocephalus) is a cosmopolitan species with a broad distribution that ranges from the tropics to the poles. Males are known to migrate between nutrient-rich high latitude waters and low latitude breeding grounds. In the North Atlantic, large males are found up to the southern limits of the ice edge. However, their seasonal distribution patterns remain poorly known in th

With the global population projected to reach eight billion by 2022, the world faces significant challenges associated with rapid urbanization. The migration of individuals from rural to urban areas in search of improved opportunities exacerbates the strain on resources, posing obstacles such as housing shortages, infrastructure demands, and food scarcity in growing cities. This thesis aims to add

MORC2 (Microorchidia CW type Zinc Finger protein 2) is a GHKL (gyrase, heat shock protein 90, histidine kinase, MutL) ATPase involved in chromatin remodeling and is highly conserved in eukaryotes. Mutations in the ATPase domain of MORC2 are known to cause neurodevelopmental disorders. MORC2 is recruited by the HUSH complex to target long, intronless transcription units such as LINE-1 retrotranspos

Background: Estrogen receptor alpha (ERα) is a protein that belongs to the nuclear receptor family. It is regulating the expression of genes involved in cell cycle progression, proliferation, and apoptosis. Approximately 75% of breast cancers express ERα, making it an important target for treatment. Researchers have identified various isoforms of ERα, with the most well-characterized one being a 6

This thesis investigates how AI-generated music challenges traditional systems of cultural legitimacy, identity, and musical taste. Drawing on Bourdieu’s theory of cultural fields and symbolic capital, and supplemented by Simon Frith’s insights into authenticity and identity performance, the study examines how emerging technologies reconfigure creative authority within platform-driven environments

Volcanic eruptions can have severe societal and environmental impacts as shown by ash dispersal and sulphur emissions from recent Icelandic eruptions. However, ice-core sulphur records demonstrate that these events were minor as compared to eruptions of much larger magnitude in recent centuries, with severe implications for past society documented in historical records. Biological and chemical evi

There is a global concern about the decline of wild pollinators and the ecosystem services they provide. Although land-use change is a major threat to biodiversity, it is still poorly understood how land-use heterogeneity (or land-use structure) impacts pollinator communities and entomophilous crop production. Based on a literature review, we performed a meta-analysis to (1) assess how landscape s

Determining the appropriate duration for traffic conflict observation remains a critical yet unresolved challenge in road safety analysis. Existing approaches lack a quantitative approach to determine adequate sample sizes for general conflict-based applications. This study addresses this gap by proposing an extreme value theory based framework to determine appropriate observation durations, based

Unlike most bacteria, Streptomyces grows by extending branching hyphae, forming a mycelium that resembles fungal growth more than typical prokaryotic behaviour. This growth strategy leads to questions about how bacteria control cell shape, polarity, and development in a multicellular context. While many regulatory systems involved in Streptomyces development have been described, others remain poor

Combined quantum mechanics and molecular mechanics (QM/MM) calculations are a popular approach to study reaction mechanisms of enzymes. However, recently, the reproducibility of such calculations has been questioned, comparing the results of two software: NWChem and Q-Chem. Here, we continue and extend this study by including three additional software─ComQum, ORCA, and AMBER─using the same test ca

Background: Peritoneal recurrence (PREC) following nephrectomy for localized renal cancer (RCC) is rare. Our objective was to report a multicenter analysis of PREC to analyze incidence, treatment, survival and risk factors. Methods: Between 1987 and 2023, patients with PREC following radical or partial nephrectomy (PN) for localized RCC across ten European institutions (UroCCR, NKI, IRCCS, Foch an

The radioactive noble gas radon (222Rn) is a suitable tracer for atmospheric transport and mixing processes that can be used to evaluate and calibrate atmospheric transport models or to estimate greenhouse gas (GHG) emissions using the so-called radon tracer method (RTM). However, these applications require reliable estimates of the 222Rn fluxes from the soil. This study evaluates two process-base

Dissolved organic matter (DOM) is a major source of macronutrients to freshwaters, yet it has variable and poorly understood bioavailability. Because intrinsic variation in bioavailability is caused by chemical structures of organic nutrients, DOM composition data should improve predictions of bioavailable resource pool sizes. We hypothesized that bioavailable organic carbon (C) and nitrogen (N) f

Examining the archaeological material of the modern period, over a period of the last 500 years, this open access book presents a series of case studies that challenges the fallacy of Nordic egalitarianism. The widening gap between rich and poor Western countries is now a well-known phenomenon and, while Scandinavia has often been hailed as one of the regions where inequality has been the lowest,

Organic pollutants in aquatic environments pose a threat to ecosystems and human health, a challenge that requires urgent resolution. This urgent threat highlights the need for the development of efficient technologies for pollutant detection and degradation in environmental protection. This study presents the successful fabrication of a composite nanomaterial consisting of Ag nanoparticle-decorat

Aducanumab, a human IgG1 antibody with plaque-clearing effects and modest clinical benefit, binds selectively to aggregated Aβ via the N-terminal region. Yet, the molecular details of how the antibody engages Aβ1-42 fibrils remain unresolved. Using magic-angle spinning NMR, we show that binding of aducanumab preserves the overall architecture of the Aβ1-42 fibril core while inducing significant st