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For more than a century the research on the Antikythera Mechanism engaged scientists from a widerange of scientific disciplines searching for clues, in order to solve the mystery that this unique ar-chaeological find poses. The results so far have been spectacular enough to re-write the History ofTechnology providing new aspects on the degree of technological sophistication and scientific de-velop
BACKGROUND: Malignant melanoma is the most deadly form of skin cancer. Female sex is known to have a protective effect on incidence, tumour characteristics, and mortality from melanoma. However, the potentially modifying effect of sex on the prognostic significance of clinicopathological and investigative factors is generally not taken into consideration in biomarker studies. In this study, we com
Tunnelling below water passages is a challenging task in terms of planning, pre-investigation and construction. Fracture zones in the underlying bedrock lead to low rock quality and thus reduced stability. For natural reasons, they tend to be more frequent at water passages. Ground investigations that provide information on the subsurface are necessary prior to the construction phase, but these ca
Streptococcus pyogenes is known to cause both mucosal and systemic infections in humans. In this study, we used a combination of quantitative and structural mass spectrometry techniques to determine the composition and structure of the interaction network formed between human plasma proteins and the surfaces of different S. pyogenes serotypes. Quantitative network analysis revealed that S. pyogene
I denna avhandling beskrivs processesen att implementera och optimisera metoder inom kvantitativ magnetresonansomografi (MRT) på en fältstyrka av 7 T. Metoderna är baserade på gradientekon med påtvingad transversell urfasning (spoiling) och applicerade på den mänskliga hjärnan i syfte att avbilda i huvudsak tre olika MR-parametrar: Den longitudinella relaxationstiden (T1), magnetization transfer s
There is an urgent need for treatments that not only reduce bacterial infection that occurs during wounding but that also target the accompanying excessive inflammatory response. TCP-25, a thrombin-derived antibacterial peptide, scavenges toll-like receptor agonists such as endotoxins and lipoteichoic acid and prevents toll-like receptor-4 dimerization to reduce infection-related inflammation in v
Phosphatocopids are a group of small extinct marine crustaceans, which occur widespread in Cambrian dysoxic benthic lithofacies. Whereas the anatomy of the earliest ontogenetic stages of phosphatocopids, from the head larva with four pairs of appendages onward, is well documented, that of more advanced or adult growth stages has remained almost unknown (except for the external shields). Here we de
BACKGROUND: Fast-tracking and early endotracheal extubation have been described in patients undergoing surgery for congenital heart disease (CHD); however, criteria for patient selection have not been validated in a prospective manner. Our goal in this study was to prospectively identify factors associated with the decision to defer endotracheal extubation in the operating room (OR).METHODS: We pe
Animals, like humans, need to perceive their surroundings via their senses in order to make sensible behavioral decisions, reproduce successfully, and survive. Animals are equipped with audition, vision, thermosensation, hygrosensation, mechanosensation, magnetoception, gustation, and olfaction, which detects physical and chemical changes in their habitats. Among these senses, olfaction is likely
BACKGROUND: Most evidence for TSC-associated neuropsychiatric disorders (TAND) to date have come from small studies and case reports, and very little is known about TAND in adults. We explored baseline TAND data from the large-scale international TOSCA natural history study to compare childhood and adult patterns, describe age-based patterns, and explore genotype-TAND correlations.RESULTS: The stu
The importance of semi-arid ecosystems in the global carbon cycle as sinks for CO 2 emissions has recently been highlighted. Africa is a carbon sink and nearly half its area comprises arid and semi-arid ecosystems. However, there are uncertainties regarding CO 2 fluxes for semi-arid ecosystems in Africa, particularly savannas and dry tropical woodlands. In order to improve on existing remote-se
Some polycyclic aromatic hydrocarbons (PAH) are known carcinogens and workplace PAH exposure may increase the risk of cancer. Monitoring early cancer-related changes can indicate whether the exposure is carcinogenic. Here, we enrolled 151 chimney sweeps, 152 controls, and 19 creosote-exposed male workers from Sweden. We measured urinary PAH metabolites using LC/MS/MS, the cancer-related markers te
To address the importance of antigen-presenting cells for the survival of intracerebral neural allografts, allogeneic spleen cells were added to the graft tissue before transplantation. Dissociated embryonic, dopamine-rich mesencephalic and adult spleen tissues were prepared from either inbred Lewis or Sprague-Dawley rats. A mixture of neural and spleen cells was sterotaxically transplanted into t
In a critique of the sometimes confusing ways in which the term transnational has been repeatedly used, Mette Hjort, in 2010 attempted to outline what she called a “typology of transnationalisms” in connection with contemporary audio-visual production (2010: 12–33). Hjort’s palpable purpose here was to more precisely illuminate and contextualize the increasingly used concept of transnationalism. A
OBJECTIVES: To examine the mortality pattern and the cancer incidence in a cohort of long term smelter workers exposed to lead.METHODS: The cohort consists of 664 male lead battery workers, employed for at least three months in 1942-87. From 1969 the values of all blood lead samples repeatedly obtained from these workers every two to three months, have been collected in a database. The expected mo
Biomarkers are used in molecular biology to predict characteristics of interest and are applied in agriculture to accelerate the breeding of target traits. Proteomics has emerged as a promising technology for improved markers by providing a closer view to the phenotype than conventional genome-based approaches. However, a major challenge for biomarker development is that the identified biological
Pollination is a key ecosystem service for global agriculture but evidence of pollinator population declines is growing. Reliable spatial modelling of pollinator abundance is essential if we are to identify areas at risk of pollination service deficit and effectively target resources to support pollinator populations. Many models exist which predict pollinator abundance but few have been calibrate
The study of plant mitochondria started in earnest around 1950 with the first isolations of mitochondria from animal and plant tissues. The first 35 years were spent establishing the basic properties of plant mitochondria and plant respiration using biochemical and physiological approaches. A number of unique properties (compared to mammalian mitochondria) were observed: (i) the ability to oxidize
