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Four novel mutations in deficiency of coagulation factor XIII: Consequences to expression and structure of the A-subunit

The characterization of naturally occurring mutations is one way to approach functionally significant domains of polypeptides. About 10 mutations have been reported in factor XIII (FXIII) A-subunit deficiency, but very little is known about the effects of the mutations on the expression or the structure of this enzyme. In this study, the recent crystallization of FXIII A-subunit and determination

Foreland evolution of Blåisen, Norway, over the course of an ablation season

Denna studie presenterar en detaljerad undersökning av utvecklingen av sedimentära landformer under en ablationssäsong vid Blåisen, en del av Hardangerjøkulen, Norge. Två besök vid Blåisen, i början och i slutet av ablationssäsongen, gjorde det möjligt att studera hur landformerna bevaras och utvecklas. Det pågår mycket forskning om glaciala landformer som är en nyckel till förståelse av hur tidigThis study presents a detailed investigation into the evolution of sedimentary landforms over an ablation season at Blåisen, an outlet of the Hardangerjøkulen Icecap, Norway. The two visits to Blåisen, one each side of the ablation season, allowed the preservation and evolution of the landforms to be studied. Much research is conducted studying glacial landforms, which are key in our understanding

Studier av framkomlighet i en korsning - genom VISSIM simuleringar

Det här examensarbetet handlar om att undersöka hur framkomligheten ser ut i korsningen Karlsrovägen-Västrevångleden i Halmstad kommun. Det är en trevägskorsning utan någon signalreglering och, cykel- och gångtrafiken är separerad från biltrafiken. Innan fokus läggs på själva korsningen presenteras kunskap om hur man går tillväga för att undersöka framkomlighet och trafiksäkerhet samt innebördenThis thesis is about investigating what the passability looks like at the crossing Karlsrovägen-Västrevångleden in Halmstad municipality. It is a three-way intersection without any signal control and, bicycle and pedestrian traffic is separated from car traffic. Before focusing on the crossing itself, information is presented on how to proceed to investigate passability and traffic safety, as wel

Är tiden inne för virtuella bolagsstämmor? - En analys av regleringen av bolagsstämmor i privata aktiebolag.

I takt med den ständigt pågående tekniska utvecklingen ökar även efterfrågan av digitalisering av allt fler funktioner i samhället. Många processer, transaktioner och handlingar som tidigare skedde på plats och genom möten sker idag digitalt. Bankärenden är ett av många exempel på detta, vilket tydliggjordes i Internet Stiftelsens årliga undersökning 2019, Svenskarna och Internet, då 91% av svensk

Optimization of a sampling and analysis process to study the effects of skin care products on the microbial skin flora.

Vår hud är hem för en stor grupp av mikroorganismer, hudens mikroflora, som påverkar vår hälsa och vårt välbefinnande. Ändå finns det många aspekter av detta ämne som ännu är outforskade. Detta projekt syftade till att optimera en metod för analys av hudens mikroflora och effekten av hudvårdsprodukter på hudens mikroflora, från provtagning och provberedning till analys med kvantitativ polymeraskedOur skin is home to a vast community of microorganisms, the skin micro flora, which affect our health and well-being. Yet, there are many aspects of this topic that are still unexplored. This project aimed to optimize a method for analysis of the skin micro flora and the effect of skin care products on the skin micro flora, from sampling and sample preparation to analysis with quantitative polymer

Impact of MLC shape smoothing on VMAT plan complexity and agreement between planned and delivered dose

Alla påverkas av cancer, direkt eller indirekt och under de senaste decennierna har antalet cancerfall ökat. Med strålbehandling kan man bekämpa cancern genom att bestråla tumören med joniserande strålning samtidigt som man försöker skydda omkringliggande frisk vävnad i den mån det går. Med dagens teknik kan man uppnå bättre tumörkontroll samtidigt som den friska vävnaden kan skyddas i större utrsBackground/Purpose: The aperture shape controller (ASC) was introduced in the Eclipse treatment planning system to reduce plan complexity by counteracting irregular multileaf collimator (MLC) shapes. This should lead to decreased difference between the planned and measured dose distribution. The ASC was investigated to examine if it could limit plan complexity so that the planned and measured dose

Lärande och minnande på demensvisningar : en komparativ fallstudie av pedagogik inom demensvisningar på museer

This master’s thesis focuses on pedagogy and aspects of learning and remembering within guided museum tours for people with dementia. We explore in what way learning and remembering are focused on and triggered during those tours and with the help of which pedagogical means. Furthermore, we discuss what place these tours have within the museum as an institution. In order to examine our questions a

What is the Real Cost of Purchasing? - A comparison between purchasing offshore and purchasing nearshore

The product price given when producing offshore is not the entire truth and more companies decide to move their offshore production nearshore (Stentoft et. al, 2016). To measure the actual cost of producing many more parameters than visible costs needs to be taken account for. There are advantages as well as risks with outsourcing and costs can increase with distance such as quality issues, freigh

A study of DGAT enzymes from Tropaeolum majus with focus on oil biosynthesis

An alternative energy and chemicals must be found to meet the future demand. A possible source of renewable energy is plant oil since it has a close chemical structure to fossil oil with less refining requirement. However, vegetable oil has not made a significant contribution to replace fossil oil as an energy source because of high demand of fossil oil. It is possible to substitute fossil-based c

Production process development of adhesive dispensing with focus on cost and quality.

In our society, digital cameras are used for a countless number of different purposes. There are many components going in to making such a complex product but one could argue that the camera sensor and lens make out the heart of a digital camera. Axis Communications AB, founded in 1984, is a Swedish company which pioneered and specialize in digital network cameras. In 1996 Axis delivered the first

Death as an architect of societies: Burial and social identity during the Viking Age in South-western Scania

In this thesis I explore the subject on how burial was used by Viking Age population of South-western Scania to express their social identity. As opposed to most earlier research concerning Viking Age burials I utilise regional, mourner-centred and practice-based approach. I am following observations conducted for burials in Denmark by J. Ulriksen (2011), focused on traces of deposition of burned

Switching to the “Golden Age of Natural Gas” with a focus on shale gas exploitation : a possible bridge to mitigate climate change?

Currently, policy makers put high attention in supplying global energy demand by focusing on 2°C policy; global temperature anomaly based on the global mean temperature of pre-industrial era (13.7°C). How to keep the 2°C policy at global scope is the main question in climate framework. It is widely believed that primary energy resources (mainly coal, oil and natural gas) with focus on shale gas re

Genome-wide Profiling of the Histone Modification Status in Hutchinson-Gilford Progeria Syndrome

Children affected by the multisystem genetic disorder Hutchinson-Gilford Progeria Syndrome look prematurely aged, suffer from elderly-related conditions and die during adolescence due to cardiovascular complications. The cause of the disease is single point gain-of-function mutations in the LMNA gene, which encodes the lamin A and lamin C proteins, major components of the nuclear lamina. These mut

Density distributions of juvenile fish in South Australia - Focusing on the influence of coastal habtitats on climate change-induced range shifts in fish

How will baby fish react to global warming? As most people have been aware of, global warming is just one of many consequences of climate change and increasing CO2-levels in the atmosphere. The oceans are experts at absorbing energy, which makes the ocean temperature rise. In many parts of the world, especially Australia, the sea surface temperatures (SSTs) are increasing rapidly today. This is e

Allocation of a European DC to Minimize LUL Shipments for Companies within the Aged Alcoholic Beverage Industry

Titel: Placering av europeiskt distributionscentrum för att minska LUL-transporter för företag inom industrin för lagrade alkoholhaltiga drycker Författare: Josefin Berntson, Cecilia Flink Handledare: Sebastian Pashaei, Avdelningen för industriell ekonomi och logistik, Lunds Tekniska Högskola, Lunds universitet. Problembeskrivning: Den ökade efterfrågan av distribution, som ett resultat av den Title: Allocation of a European Distribution Center to Minimize LUL Shipments for Companies within the Aged Alcoholic Beverage Industry Authors: Josefin Berntson, Cecilia Flink Supervisor: Sebastian Pashaei, Department of Industrial Management and Logistics, Faculty of Engineering, Lund University Problem description: The increased demand for distribution as a result of the globalization has in

Photo-electrochemical communication between thylakoid membranes and electrodes for harnessing sunlight

Development of environmentally friendly and cost-efficient energy sources has been a challenge for modern society since long ago. Sunlight is an infinite and costless source of energy on Earth, so it would be an enormous advantage to efficiently harvest and transform it into electrical energy used in our everyday life. In nature the process, which converts light energy into chemical energy, is cal

De kom, de klickade, de övergav

Företaget, vars webbstatistik ligger till grund för analyserna i uppsatsen, verkar inom retail. Produktsortimentet innehåller mode för dam, barn och herr samt inkluderar även produkter inom kategorierna möbler, heminredning och elektronik. Under de diskussioner som föranlett uppsatsen uttrycker företagaren en önskan att få veta när det är tryggt för dem att störa en kund i kassan, exempelvis med eThis thesis analyses web statistics belonging to a national B2C e-commerce in retail. The purpose of the thesis is to investigate abandoned carts amongst logged in customers with at least one product added in to their cart and at least one visit to the payment page. Since the response variable "cart" is binary and we are studying the probability of a cart being abandoned, the suitable me

Monitoring of heat exchanges in thesnowpack of Foxfonna glacier, Spitzbergen,Svalbard.

The processes of meltwater storage in firn and the impact of refreezing on firn-coveredglaciers have been investigated on the Greenland ice-sheet. On Svalbard, climate changepromotes the disappearance of firn on glaciers. This thesis project aims to monitor theheat exchanges between the snowpack and the ice surface on a non firn-covered glacier,on Foxfonna, Spitzbergen, Svalbard, and to draw the p

Elite and non-elite agenda-setting on Twitter: the case of #almedalen 2018

In this paper, we study activity on Twitter in relation to the Swedish political festival Almedalsveckan, a week-long event where political parties, interest organizations, corporations and other actors for decades have gathered on the island of Gotland to discuss politics and public affairs. In 2018, a total of 4311 events (speeches, seminars, debates etc.) were arranged by 1929 separate actors a

2-cm versus 4-cm surgical excision margins for primary cutaneous melanoma thicker than 2 mm : long-term follow-up of a multicentre, randomised trial

Background: The optimal surgical excision margins are uncertain for patients with thick (>2 mm) localised cutaneous melanomas. In our previous report of this multicentre, randomised controlled trial, with a median follow-up of 6·7 years, we showed that a narrow excision margin (2 cm vs 4 cm) did not affect melanoma-specific nor overall survival. Here, we present extended follow-up of this cohort.