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Collagen XVI is integrated tissue-dependently into distinct fibrillar aggregates, such as D-banded cartilage fibrils and fibrillin-1-containing microfibrils. In skin, the distribution of collagen XVI overlaps that of the collagen-binding integrins alpha 1 beta 1 and alpha 2 beta 1. Basal layer keratinocytes express integrin alpha 2 beta 1, whereas integrin alpha 1 beta 1 occurs in smooth muscle ce
Mapping of the spatial and temporal motion of particles inside an optical field is critical for understanding and further improvement of the 3D spatio-temporal control over their optical trapping dynamics. However, it is not trivial to capture the 3D motion, and most imaging systems only capture a 2D projection of the 3D motion, in which the information about the axial movement is not directly ava
Arctic waders are well known for their impressive long-distance migrations between their high northerly breeding grounds and wintering areas in the Southern hemisphere. Performing such long migrations requires precise orientation mechanisms. We conducted orientation cage experiments with juvenile sharp-tailed sandpipers (Calidris acuminata) to investigate what cues they rely on when departing from
We have investigated the inhibition of the recently identified family C13 cysteine peptidase, pig legumain, by human cystatin C. The cystatin was seen to inhibit enzyme activity by stoichiometric 1:1 binding in competition with substrate. The Ki value for the interaction was 0.20 nM, i.e. cystatin C had an affinity for legumain similar to that for the papain-like family C1 cysteine peptidase, cath
Gruppen driver forskning kring mätning och behandling av svår kronisk andnöd (dyspné) samt behandling av kronisk andningssvikt. Gruppen har nära samarbete med ledande forskare nationellt och ett internationellt forskningsnätverk kring klinisk dyspnéforskning. Studier inkluderar epidemiologiska analyser, Cochrane meta-analyser, kliniska kohortstudier samt randomiserade kontrollerade behandlingsstudThe research group focuses on the mechanisms, measurement and treatment of severe chronic breathlessness (dyspnea) and management of chronic respiratory failure. The research is conducted in close collaboration with leading researchers nationally and an international research network. Studies include epidemiological analyses, Cochrane meta-analyses, clinical cohorts and randomized controlled trial
A large portion of atmospheric aerosol particles consists of secondary material produced by oxidation reactions. The relative importance of secondary organic aerosol (SOA) can increase with improved emission regulations. A relatively simple way to study potential particle formation in the atmosphere is by using oxidation flow reactors (OFRs) which simulate atmospheric ageing. Here we report on the
Recent models have worked with the assumption that birds try to minimize either time, energy or predation risk during migration, or some combination of these. The few empirical studies available have suggested that time minimization may be the most common strategy. One way of distinguishing between strategies is to study the departure decisions of migrating birds. We supplied migrating European ro
Geophysical methods are increasingly being applied to geotechnical investigations, as they can identify material properties and material boundaries, as well as variations in space and time of relatively large volumes of soil. Another advantage is that many of these methods are non-intrusive. The combination of several methods and the verification of their results by sampling and correlating with g
