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Planning and execution of large infrastructure projects benefit from detailed mapping of the subsurface through geophysical methods. However applying geophysical methods in an urban environment requires careful preparation to ensure success in areas where source of noise and present infrastructure may compromise the results. We present and discuss the results of a seismic investigation conducted i
It is a well-known fact that sustainable development goals are difficult to achieve without a proper water resources management strategy. This study tries to implement some state-of-the-art statistical and data mining models i.e., weights-of-evidence (WoE), boosted regression trees (BRT), and classification and regression tree (CART) to identify suitable areas for artificial recharge through flood
The heterodimer HIF-1α (hypoxia inducible factor)/HIF-β (also known as ARNT-aryl hydrocarbon nuclear translocator) is a key mediator of cellular response to hypoxia. The interaction between these monomer units can be modified by the action of small molecules in the binding interface between their C-terminal heterodimerization (PasB) domains. Taking advantage of the presence of several cysteine res
The role of K396 in the enzymatic catalysis and the antigenicity of the 65 kDa isoform of glutamate decarboxylase (GAD65) was analyzed using the K396R GAD65 mutant. GAD65 is a major autoantigen in Type 1 diabetes and autoantibodies directed to GAD65 are widely used markers for this disease. We found that (1) recombinant human GAD65 is fully enzymatically active; (2) the K396R mutation abolished GA
This thesis explores the question of whether European States, with a specific emphasis on European Union (EU) Member States, can be held responsible for the enforced disappearance of migrants in the Mediterranean Sea under the European Convention on Human Rights (ECHR). Following the migration crisis of 2015, EU policy and measures on migration revealed a strong focus on protecting the external bo
Det övergripande målet i vår forskning är att kartlägga och studera rollen för olika kinas-nätverk i fettväv, eftersom denna vävnad deltar vid uppkomst av t2d. Huvudsakligt fokus är på en kinas-familj bestående av amp-aktiverat proteinkinas (ampk) och 12 av dess släktingar, varav vi är särskilt intresserade av salt-inducerade kinaser (sik). Vi har visat att sik2-nivån är sänkt i fettväv från indivAn overall aim of our research is to study the regulation and function of protein phosphorylation cascades with relevance to type 2 diabetes, with a particular focus on adipose tissue, since this tissue is involved in the pathogenesis of diabetes. Presently, our main project evolves around the amp-activated protein kinase (ampk) family, which consists of ampk and another 12 related kinases, of whi
Reprogramming somatic cells to induced pluripotent stem (iPS) cells and directed differentiation opens up for studies on neural cells from patients. The Falk group is focusing on fundamental questions in early human neurogenesis. We build cellular models of the healthy and diseased human brain using reprogrammed patient cells. We derive patient specific iPS cells that are further differentiated in
Abstract in German Nach ihrem Amtsamtritt im September 2006 hat die schwedische Mitte-Rechts-Regierung im Januar 2007 die Beiträge zu den Arbeitslosenkassen der Gewerkschaften erheblich erhöht. Dadurch wurde es plötzlich wesentlich teurer, Mitglied in einer Gewerkschaft (und in der Arbeitslosenkasse) zu sein. Innerhalb von zwei Jahren verloren die Gewerkschaften 8% ihrer Mitglieder, der gewerkschaIn January 2007 the Swedish centre-right government in office since September 2006 raised considerably fees for union unemployment funds. Union membership (fund membership included) therefore suddenly became much more expensive. Trade unions lost 8% of their members over two years and union density fell by 6 percentage points (from 77% in 2006 to 71% in 2008), while unemployment funds were hit by
This dissertation deals with the characteristic variation found in adult French L2 oral production. In their production of regular verbs, beginners use a short form, like parle, and a long form, like parlE, in contexts of both the present (je parl/*je parlE) and the infinitive (je veux parlE/*je veux parl). This sometimes results in target-like uses and sometimes not. The question addressed in th
I princip alla forskningsprojekt i forskargruppen grundar sig på ett intresse för samspelet mellan sjukdomsframkallande mikroorganismer och människan. Vi använder oss av ett antal olika metoder för att studera detta samspel på molekylär, cellulär, vävnads och organismsnivå. Samevolutionen mellan dessa mikroorganismer och den mänskliga värden har lett till ett stort antal interaktioner som påverkarBasically all projects within the research group emanates from an interest in the interaction between pathogenic microorganisms and the human host. We are using an array of different methods to study this interaction on a molecular, cellular, tissue, and organism level. The co-evolution between microorganisms and the human host has lead to a vast array of interactions influencing the outcomes of
http://portal.research.lu.se/portal/sv/persons/ewa-sitnicka-quinn(e833d81c-751c-4f6f-bee9-5e570e7ad9e4).html">Ewa Sitnicka Quinn är forskargruppsledare för forskargruppenhttp://portal.research.lu.se/portal/en/persons/ewa-sitnicka-quinn(e833d81c-751c-4f6f-bee9-5e570e7ad9e4).html">Ewa Sitnicka Quinn is Research Group Leader for this research group
