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Former research indicates that the crack width close to the bar can be a better indicator for the risk for reinforcement corrosion than, as current concrete codes impose, the crack width at the concrete surface. In this paper a finite-element model is used to increase the understanding of how the crack width varies at different levels from the reinforcement and how different mechanisms control thi

Most of the common modeling approaches to premixed combustion in engineering applications are either based on the assumption of infinitely fast chemistry or the flamelet assumption with simple chemistry. The level-set flamelet library approach (FLA) has shown great potential in predicting major species and heat release, as well as intermediate and minor species, where more simple models often fail

Adult patients with acute lymphoblastic leukaemia ( ALL) have been treated according to national protocols in Sweden since 1986. Stem cell transplantation (SCT) has been recommended in first remission for patients with risk factors for relapse, and for standard risk patients only after relapse. In this retrospective study, the results of autologous and allogeneic SCT in these populations were eval

We present a new software framework for Markov chain Monte Carlo sampling for simulation, prediction, and inference of protein structure. The software package contains implementations of recent advances in Monte Carlo methodology, such as efficient local updates and sampling from probabilistic models of local protein structure. These models form a probabilistic alternative to the widely used fragm

Male patients with terminal renal failure are often infertile and exhibit an abnormal sex hormone pattern in plasma. We studied patients in all chronic kidney disease (CKD) stages to determine plasma levels of anti-Müllerian hormone (AMH), a Sertoli cell-derived marker, and other sex hormones. Seventy-eight male patients with CKD stages 1-5 and a median age of 40 years (22-50 years), as well as 20

Chemical sensitization is an adverse immunologic response to chemical substances, inducing hypersensitivity in exposed individuals. Identifying chemical sensitizers is of great importance for chemical, pharmaceutical and cosmetic industry, in order to prevent the use of sensitizers in consumer products. Historically, chemical sensitizers have been assessed mainly by in vivo methods, however, recen

Denna uppsats behandlar en nyligen avkunnad dom från Mark-och miljööverdomstolen. Rättsfallet som rör ett moderbolags miljöansvar för sitt helägda dotterbolags miljöskador är intressant både ur en miljö-och bolagsrättslig aspekt. Miljöansvaret faller primärt på verksamhetsutövaren och sekundärt på markägaren. Detta är reglerat i miljöbalken och har ägnats en hel del uppmärksamhet i praxis, förarbeThe present study deals with a recently delivered judgment from the Environmental court of appeal. The case deals with the issue of parent company liability for contamination, which is interesting from both an environmental and a company point of view. The environmental responsibility primarily lies on “the operator” and secondarily on the property owner. This is regulated in the Swedish environme

Denna uppsats syftar till att utreda brottet vållande till annans död och var gränsen går för en rättssäker tolkning av dess straffbuds ordalydelse. Specifikt fokuseras på frågan om straffbudet kan ta sikte på den som medelst kränkande behandling av någon annan orsakar att vederbörande begår självmord. Då medverkansansvar förutsätter medverkan till en otillåten gärning, utgör inte medverkan till The purpose of this essay is to investigate the crime of involuntary manslaughter in Swedish law and the boundaries for a lawful interpretation of the provision. Specifically, it focuses on whether the provision may take aim at someone whose degrading treatment causes someone else’s suicide. Since responsibility for complicity requires complicity to an illegal act, complicity to suicide is not a

Among adolescents, loneliness is common. One kind of loneliness, existential loneliness, is understood as a painful part of the human condition. During adolescence, existential loneliness has been shown to be challenging to navigate independently. Therefore, this study aimed to explore Swedish adolescents’ experiences of existential loneliness regarding receiving and providing support. This study

Protein synthesis, measured as [14C]-leucine incorporation into proteins, was studied in the normothermic rat brain following 15 min of transient cerebral ischaemia and 1 h, 24 h and 48 h of recirculation, and in the hypothermic (33°C) brain following 1 h and 48 h of recirculation. Ischaemia was induced by bilateral common carotid occlusion combined with hypotension. Following normothermic ischaem

Apartment buildings have been built in a wind exposed area situated close to the seaside in Malmö, Sweden. Several goals when building these apartments have been articulated, for example low energy usage, validation of the leakage factor and a satisfying indoor environment. The purpose of this study is to examine how the people living in the apartments experience the indoor climate. Their experien

We tested the chondrogenic potential of demineralized allogeneic bone matrix (DABM) in the repair of osteochondral defects. In 42 adult rabbits, a 5-mm2 or 15-mm2 defect was created bilaterally in the intercondylar groove of distal femur. DABM was inserted directly in 37 defects, whereas in 35 it was inserted after previous placement in muscle for 4, 16, or 19 days. Another 12 defects were left em

PurposeAntimicrobial resistance increases with the use of broad-spectrum antibiotics. Studies evaluating antibiotic stewardship are in high demand. Is piperacillin/tazobactam non-inferior to carbapenems regarding 30-day mortality among patients with bloodstream infections caused by extended-spectrum beta-lactamase-producing Enterobacterales?MethodsThis retrospective, multicenter, non-inferiority,

Background: The contribution of endothelial injury in the pathogenesis of COVID-19-associated acute respiratory distress syndrome (ARDS) and resulting respiratory failure remains unclear. Plasma endostatin, an endogenous inhibitor of angiogenesis and endothelial dysfunction is upregulated during hypoxia, inflammation and progress of pulmonary disease. Aim: To investigate if plasma endostatin is as

Nemo-like kinase (NLK) is a member of the mitogen-activated protein kinase family of kinases and shares a highly conserved kinase domain with other mitogen-activated protein kinase family members. The activation of NLK contributes to the pathogenesis of Diamond–Blackfan anemia (DBA), reducing c-myb expression and mechanistic target of rapamycin activity, and is therefore a potential therapeutic ta

Prisons are institutions through which states exert social control and deprive citizens of rights; where entitlements of citizens are limited to the bare minimum deemed acceptable to a given state. Therefore, prisons are institutions which reveal core aspects of the relation between a state and its citizens. In authoritarian regimes, as Myanmar was in a very recent past, prisons are places in whic

An improved understanding of the emerging business models for hydrogen applied in the transport sector is crucial to remove barriers for hydrogen uptake. The aim of this study is to create a characterisation of the current landscape for hydrogen road mobility in Sweden by mapping out the business model for hydrogen producers, hydrogen filling station owners and hydrogen vehicle manufacturers. This

Objective To update the epidemiology of anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) in a defined geographical area of southern Sweden.Methods The study area comprised 14 municipalities with a combined adult population (≥18 years) of 623 872 in 2019. All cases diagnosed with AAV in 1997–2019 in the study area were included in the estimate of incidence. Diagnosis of AAV was veri