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Objective: The incidence of urinary stones is increasing across the globe. Surgical treatment includes extracorporal shock-wave lithotripsy (ESWL), ureterolithotripsy (URS), percutaneous nephrolitotomy (PCNL) and rarely open surgery. This single center study describes complications to PCNL focusing on infections, bacterial growth/resistance and antibiotic prophylaxis/treatment. Materials and metho
Background Declines from high levels of under-5 mortality rate (U5MR) first occurred in Western Europe. Knowledge and technologies gained from early mortality reductions could accelerate the U5MR decline for countries that followed. We explored whether average annual reduction (AAR) in U5MR increased between countries over time in the 20th century.Methods We used U5MR time series from the Human Mo
The breakup of the L-chondrite parent body (LCPB) in the mid-Ordovician is the largest documented asteroid breakup event during the past 3 Gyr. It affected Earth by a dramatic increase in the flux of L-chondritic material and left prominent traces in both meteorite and sedimentary records. A precise constraint on the timing of the LCPB breakup is important when evaluating the terrestrial biotic an
Introduction: Atypical hemolytic uremic syndrome (aHUS) is a progressive and potentially life-threatening disease characterized by complement-mediated thrombotic microangiopathy. Patients with aHUS may experience fatigue, which can negatively impact their lives, but there is a knowledge gap regarding disease burden in these patients. Methods: In this longitudinal study, patients with aHUS from the
Background: Somali women suffer from one of the highest maternal mortality rates in the world. Somalia characterises a specific low-income country situation with a mix of newly urbanized and nomadic culture combined with a frail health care infrastructure set in a post-conflict era. Very little is known about the effects that these contextual factors can have on maternal mortality. Objectives: To
Background: Glucose is a routine emergency sample. General guidelines for inpatient hyperglycemia are scarce, except in myocardial infarction, stroke, and perioperative/ICU. Previous studies found admission glucose associated with increased mortality in specific conditions. Scandinavian data, and for general patients, are scarcer. We investigated admission glucose levels, 30-day mortality, and len
The aim of this study was to evaluate the beta cell and incretin function in patients with HNF4A and HNF1A MODY during a test meal. Clinical characteristics and biochemical data (glucose, proinsulin, insulin, C-peptide, GLP-1 and GIP) during a test meal were compared between MODY patients from eight different families. BMI-matched T2D and healthy subjects were used as two separate control groups.
OBJECTIVES: To investigate hip dysplasia as a risk factor for clinically relevant and incident radiographic hip OA.METHODS: From a prospective cohort (CHECK) of 1002 middle-aged, new consulters for hip and/or knee pain, 468 hips (251 individuals) were selected based on hip pain, available lateral center edge angle (LCEA) and absence of definite radiographic hip OA (Kellgren and Lawrence [KL] grade
Purpose: The purposes are to evaluate the change in mammographic density within individuals across screening rounds using automatic density software, to evaluate whether a change in breast density is associated with a future breast cancer diagnosis, and to provide insight into breast density evolution. Approach: Mammographic breast density was analyzed in women screened in Malmö, Sweden, between 2
Coffee is epidemiologically linked to health benefits and risks. Coffee is thought to be a diuretic. However, it can still contribute to daily fluid intake. Vasopressin is the most important physiological regulator of body fluid balance and diuresis. This study aimed to map the effects of coffee intake on vasopressin concentration. In the population-based cross-sectional Malmö Offspring Study (n =
PURPOSE: To explore the effect of different posterior-inferior tibial slope (PITS) angles on ACL injury at non-contact sports, knee laxity and the need for ACL reconstruction. METHODS: One hundred patients with an acute, arthroscopically verified total ACL rupture were followed prospectively with the intention of treating the injury without reconstruction. Knee laxity was assessed with the Lachman
We sought to assess the feasibility and estimate the benefit of sparing the neurogenic niches when irradiating the brain of pediatric patients with medulloblastoma (MB) based on clinical outcome data. Pediatric MB survivors experience a high risk of neurocognitive adverse effects, often attributed to the whole-brain irradiation that is part of standard management. Neurogenesis is very sensitive to
AIMS: Determination of the myocardium at risk (MaR) and final infarct size by cardiac magnetic resonance imaging (CMR) enables calculation of salvaged myocardium in acute infarction. T2-weighted imaging is performed prior to the administration of gadolinium, since gadolinium affects T2 tissue properties. This is, however, difficult in an ex vivo model since gadolinium must be administered for dete
We aimed to estimate the 15-year and lifetime risks of contralateral breast cancer in breast cancer patients according to the age of diagnosis of the first cancer and the history of breast cancer in the mother. The risks of contralateral breast cancer were estimated for all 78,775 breast cancer patients in the Swedish Family-Cancer Database (age at diagnosis of first breast cancer <70 years). The
Objectives. To identify patients with severe extra-articular RA (ExRA) in an early RA cohort and to investigate potential risk factors. Methods. From a cohort (n = 2900) in a structured programme for newly diagnosed RA, 40 patients with severe ExRA after RA diagnosis were identified. Disease activity score (DAS28), functional disability (HAQ) and treatment with glucocorticosteroids (GCs) and DMARD
Nilsson MH, Rehncrona S, Jarnlo G-B. Fear of falling and falls in people with Parkinson's disease treated with deep brain stimulation in the subthalamic nuclei. Acta Neurol Scand: 2011: 123: 424-429. © 2010 John Wiley & Sons A/S. Background - No previous study prospectively investigated the effects of subthalamic deep brain stimulation on fear of falling (FOF) and falls. Aim - The aim was to p
With the growth of the cloud industry in recent years, the energy consumption of the underlying infrastructure is a major concern.The need for energy efficient resource management and control in the cloud becomes increasingly important as one part of the solution, where the other is to reduce the energy consumption of the hardware itself.Resource management in the cloud is typically done using rel
ObjectivesCancer related pain (CRP) is among the most frequent collateral effects of cancer, with chronic CRP, lasting at least three months, affecting >40% of cancer survivors.Evidence based treatments, including pain-focused Cognitive Behavioral Therapy(CBT) are available, but it appears that cancer patients/survivors are often poorlyinformed about CRP or the potential benefits of CBT for such p
Aims/hypothesis We aimed to investigate the risk of cancer mortality in relation to the glucose tolerance status classified according to the 2 h OGTT. Methods Data from 17 European population-based or occupational cohorts involved in the DECODE study comprising 26,460 men and 18,195 women aged 25-90 years were collaboratively analysed. The cohorts were recruited between 1966 and 2004 and followed
Popular Abstract in Swedish Populärvetenskaplig sammanfattning Hyaluronan (hyaluronsyra) är en högmolekylär polysackarid som förekommer i all biologisk vävnad i olika koncentrationer, med särskilt höga nivåer i bindväv. Den kan bildas av de flesta celltyper. På molekylär nivå föreligger den i form av ett nystan, har förmågan att binda stora mängder vatten, och har en uttalad pseudoplasticitet. HyaHyaluronan has been found in the eye in varying amounts and at different sites. It is involved in physiological and pathological processes, though many aspects of its bio-logi-cal functions are still unclear. We have studied the role of iris tissue in hyal-uro-nan production in the anterior segment of the eye, and its changes after trauma. After peripheral iridectomy or argon laser treatment, the
