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BRCA2 Polymorphic Stop Codon K3326X and the Risk of Breast, Prostate, and Ovarian Cancers

Background: The K3326X variant in BRCA2 (BRCA2∗c.9976A>T p.Lys3326∗rs11571833) has been found to be associated with small increased risks of breast cancer. However, it is not clear to what extent linkage disequilibrium with fully pathogenic mutations might account for this association. There is scant information about the effect of K3326X in other hormonerelated cancers. Methods: Using weighted lo

Measurement of single electrons and implications for charm production in Au+Au collisions at root(NN)-N-S=130 GeV

Transverse momentum spectra of electrons from Au+Au collisions at roots(NN) = 130 GeV have been measured at midrapidity by the PHENIX experiment at the Relativistic Heavy Ion Collider. The spectra show an excess above the background from photon conversions and light hadron decays. The electron signal is consistent with that expected from semileptonic decays of charm. The yield of the electron sign

Transverse-mass dependence of two-pion correlations in Au+Au collisions at root(NN)-N-S=130 GeV

Two-pion correlations in roots(NN) = 130 GeV Au+Au collisions at RHIC have been measured over a broad range of pair transverse momentum k(T) by the PHENIX experiment at RHIC. The k(T) dependent transverse radii are similar to results from heavy-ion collisions at roots(NN) = 4.1 , 4.9, and 17.3 GeV, whereas the longitudinal radius increases monotonically with beam energy. The ratio of the outwards

The PREDICTS database: a global database of how local terrestrial biodiversity responds to human impacts.

Biodiversity continues to decline in the face of increasing anthropogenic pressures such as habitat destruction, exploitation, pollution and introduction of alien species. Existing global databases of species' threat status or population time series are dominated by charismatic species. The collation of datasets with broad taxonomic and biogeographic extents, and that support computation of a rang

Discovery and refinement of loci associated with lipid levels

Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with

Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits

Given the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist circumference, hip circumference, and waist-to-hip-ratio (133,723 individuals) and took forward 348 SNPs into follow-up (additional 137,052 individuals) in a total of

Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk

BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of 11,705 BRCA1 carriers (of whom 5,920 were diagnosed with breast and 1,839 were diagnosed with ovarian cancer), with a further replication in an additional sample of 2,646 BRCA1 carriers. We identified a novel breast cancer r

Centrality dependence of the high (PT) charged hadron suppression in Au+Au collisions at root s(NN)=130 GeV

PHENIX has measured the centrality dependence of charged hadron p(T) spectra from Au +An collisions at root(s)NN = 130 GeV The truncated mean p(T) decreases with centrality for p(T) > 2 GeV/c, indicating an apparent reduction of the contribution from hard scattering to high p(T) hadrdn production. For central collisions the yield at high p(T) is shown to be suppressed compared to binary nucleon-nu

Flow Measurements via Two-Particle Azimuthal Correlations in Au+Au Collisions at sqrt[sNN]=130 GeV

Two-particle azimuthal correlation functions are presented for charged hadrons produced in Au+Au collisions at the Relativistic Heavy Ion Collider (sqrt[sNN]=130 GeV). The measurements permit determination of elliptic flow without event-by-event estimation of the reaction plane. The extracted elliptic flow values (v2) show significant sensitivity to both the collision centrality and the transverse

Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer

Common variants in 94 loci have been associated with breast cancer including 15 loci with genome-wide significant associations (P<5 × 10-8) with oestrogen receptor (ER)-negative breast cancer and BRCA1-associated breast cancer risk. In this study, to identify new ER-negative susceptibility loci, we performed a meta-analysis of 11 genome-wide association studies (GWAS) consisting of 4,939 ER-negati

Net charge fluctuations in Au+Au interactions root s(NN)=130 GeV

Data from Au+ Au interactions at s(NN)=130 GeV, obtained with the PHENIX detector at the Relativistic Heavy-Ion Collider, are used to investigate local net charge fluctuations among particles produced near midrapidity. According to recent suggestions, such fluctuations may carry information from the quark-gluon plasma. This analysis shows that the fluctuations are dominated by a stochastic distrib

huber-06

huber-06 On the theory of presentation STEFAN HUBER (LUND UNIVERSITY ) Abstract The aim of the paper is to introduce a new information-structural category presentation and to argue for its relevance and independence from other information-structural layers. It is shown that a successful presentation consists of two steps, namely the import of a new discourse participant and its establishing (proce

https://www.sol.lu.se/fileadmin/media/forskning/workingpapers/engelska/vol06/Huber_06.pdf - 2026-04-25

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Pre-print from Phenomenology and Cognitive Sciences, 2013. 10.1007/s11097-013-9299-x. 1 Actual and non-actual motion: Why experientialist semantics needs phenomenology (and vice versa) Johan Blomberg and Jordan Zlatev Centre for Languages and Literature (CLL) Centre for Cognitive Semiotics (CCS) Lund University Abstract Experientialist semantics has contributed to a broader notion of linguistic me

https://projekt.ht.lu.se/fileadmin/user_upload/sol/ovrigt/projekt_ccs/BlombergZlatev2013-preprint.pdf - 2026-04-25

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The textbook was designed as an introduction to RBC at a basic to intermediary level given the novelty of the topic for most readers. Our overriding aim was to offer a concise, but thoughtful and informa- tive presentation of RBC and human rights issues in the Cambodian context. A key consideration was the intended audience: teachers, researchers and students at university level in Cambodia.

https://rwi.lu.se/wp-content/uploads/2024/02/2024-RBC-in-Cambodia-Textbook-compressed-1.pdf - 2026-04-26

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i Localising human rights in the context SDGs: a handbook for cities ii Localising human rights in the context SDGs: a handbook for cities Cover Garden by the Bay - Mustbeyou-Leon/Shutterstock Localising Human Rights in the Context of SDGs: a Handbook for Cities January 2022 In collaboration with: Localising human rights in the context SDGs: a handbook for cities iv Localising human rights in the

https://rwi.lu.se/wp-content/uploads/2022/03/620ed3001b5ad246260506.pdf - 2026-04-25

Microsoft Word - katrin och satu formated-14pt.doc

Microsoft Word - katrin och satu formated-14pt.doc Some thoughts on Balto-Finnic passives and impersonals KATRIN HIIETAM (INDEPENDENT SCHOLAR) & SATU MANNINEN (LUND UNIVERSITY) Abstract This working paper focuses on the question of whether the Balto-Finnic impersonal construction can be classified as active or passive. We contrast it with the criteria for impersonal active constructions, listed in

https://www.sol.lu.se/fileadmin/media/forskning/workingpapers/engelska/vol05/Hiietam-Manninen-wp05.pdf - 2026-04-25

Representations reclaimed

Representations reclaimed Pragmatics & Cognition 18:2 (2010), 273–312. doi 10.1075/p&c.18.2.03par issn 0929–0907 / e-issn 1569–9943 © John Benjamins Publishing Company Representations reclaimed Accounting for the co-emergence of concepts and experience Joel Parthemore and Anthony F. Morse University of Sussex / University of Plymouth Understanding the relationship between concepts and experience s

https://projekt.ht.lu.se/fileadmin/user_upload/sol/ovrigt/projekt_ccs/03par.pdf - 2026-04-25

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Department of Mechanical Engineering Solid Mechanics ISRN LUTFD2/TFHF–06/5115–SE(1–81) A SMALL DEFORMATION MODEL FOR THE ELASTO-PLASTIC BEHAVIOUR OF PAPER AND PAPERBOARD Master’s Thesis by Tomas Andersson Supervisors Mikael Nyg̊ards, STFI-Packforsk Anders Harrysson, Div. of Solid Mechanics Examiner Mathias Wallin, Div. of Solid Mechanics Copyright c© 2006 by Div. of Solid Mechanics, STFI-Packforsk

https://www.solid.lth.se/fileadmin/hallfasthetslara/utbildning/examensarbete/TFHF5115.pdf - 2026-04-25