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A time projection chamber (TPC) with micropattern gaseous detector (MPGD) readout is investigated as main tracking device of the International Large Detector (ILD) concept at the planned International Linear Collider (ILC). A prototype TPC equipped with a triple gas electron multiplier (GEM) readout has been built and operated in an electron test beam. The TPC was placed in a 1 T solenoidal field
Introduction: Assistive technology is required to implement the Convention of Rights of Persons with Disabilities which asserts that all people with disabilities have the right to personal mobility and available and affordable assistive technologyAim: Investigate patients’ satisfaction with their lower-limb prosthetic or orthotic device and related service delivery in Malawi and Sierra Leone and t
Intelligence scholars have described the contemporary availability ofOpen-Source Intelligence (OSINT) and the entrance of civil society actorsinto the field of intelligence as a “democratization of intelligence”, therebyportraying a fundamentally positive and inclusive enterprise. Assessingthe implications of the recent explosion of OSINT groups and activists fortraditional state intelligence acto
Climate change is expected to increase the frequency and intensity of the most severe weather-related hazards over the coming decades. The poor in developing countries are particularly susceptible to climate change, often living in informal or precarious settlements. In order to reduce the vulnerability in those areas and strengthen people´s capacities to adapt to climate change, there is a need f
Some practices are seen as so serious and damaging to competition that they are presumed to have restrictive effects on competition. Having a category of restrictions that are forbidden benefits both companies, as it creates legal certainty, and the Commission which would not not have to go through a burdensome investigation. In recent decades, the interpretation of restriction by object has cause
For patients with end-stage respiratory diseases, such as COPD, interstitial lung diseases and cystic fibrosis, lung transplantation remains the only treatable option. However, due to increasing demand and limited availability of donor lungs, risk of complications such as acute and chronic rejection, and adverse effects of immunosuppressive treatments, this is not an alternative for the majority o
The 19th century in Sweden, like in many other European countries, saw a largedecline in the quantity of Neo-Latin literary production. However, a range of skillful Latin poets may be named from this period: Johan Lundblad, Johan Tranér, Emil Söderström, Johan Bergman and others, engaged as well in translating from Swedish into Latin as in composing poems of their own. It was also in the 19th cent
Purpose: To describe the phenotype and genotype in a young woman with Danon disease. Methods: The patient underwent an ophthalmic examination including best corrected visual acuity (BCVA), fundus photography and fundus autofluorescence (FAF), full-field electroretinography (full-field ERG), multifocal ERG, optical coherence tomography (OCT) and SAP-Humphrey 30–2 at the ages of 20 and 25. Electrooc
This paper discusses the existence and scope of the morality exception from patentability, in Article 53 (a) of the European Patent Convention. The analysis will look into the history of the provision, debate its rational and interpretation by reference to three examples of technology areas: stem cell research; gene editing and AI/big data analytics.Bioscience innovation has always generated heate
Glycolipid-lectin-driven endocytosis controls the formation of clathrin-independent carriers and the internalization of various cargos such as β1 integrin. Whether this process is regulated in a dynamic manner remained unexplored. Here we demonstrate that, within minutes, the epidermal growth factor triggers the galectin-driven endocytosis of cell-surface glycoproteins, such as integrins, that are
