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Human endothelin subtype a receptor enhancement during tissue culture via de novo transcription

OBJECTIVE: Endothelin (ET) has, since its discovery, increasingly been considered a key player in the pathophysiological processes of cerebral vasospasm in the course of subarachnoid hemorrhage, although it remains unclear how ET is involved. We present data that indicate an inherent capacity of human cerebral arteries to change their sensitivity to ET. METHODS: Human cerebral arteries were obtain

Justification of Federation International de Beton, fib, 2000 model for elastic modulus of normal and high-performance concrete, HPC

This article outlines an experimental and theoretical comparison between the fib 2000 model for elastic modulus of normal concrete, NC, and HPC and 144 laboratory tests. Two dimensions of specimen were studied (diameters 56 and 100 mm) and one climate (20 degreesC, sealed or with ambient relative humidity, RE, 60%). The age dependence did not seem to be well correlated between the derived and the

J-dependent lifetimes of the 2s2p3p 4De and 2s2p3d 4Fo terms in the boron isoelectronic sequence

Lifetimes of fine-structure levels in 2s2p3p D-4 and 2s2p3d F-4(o) quartets are calculated in the boron isoelectronic sequence, for C II to F V, using a multiconfiguration Hartree-Fock approach. These quartets are known from earlier experimental and theoretical studies to have different lifetimes for different J-levels, owing to spin-induced transitions, mainly to doublet states in 2s(2)2p and 2s2

Increased expression of Ki-67 in mantle cell lymphoma is associated with de-regulation of several cell cycle regulatory components, as identified by global gene expression analysis

Background and Objectives. Mantle cell lymphoma (MCL) is an aggressive disease. Patients with this malignancy have a median survival of 3 years. To better understand disease progression, which is characterized by increased proliferation, we analyzed the gene expression of MCL with different proliferative indices, as determined by immunohistochemical staining for Ki-67. Furthermore, primary and rel

Out of the Theoretical Cul-de-sac (Commentary)

A key premise of the heuristics-and-biases program is that heuristics are “quite useful.” Let us now pay more than lip service to this premise, and analyse the environmental structures that make heuristics more or less useful. Let us also strike from the long list of biases those phenomena that are not biases and explore to what degree those that remain are adaptive or can be understood as by-prod