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A randomized phase III multicenter trial comparing irinotecan in combination with the Nordic bolus 5-FU and folinic acid schedule or the bolus/infused de Gramont schedule (Lv5FU2) in patients with metastatic colorectal cancer

Background: To compare irinotecan with the Nordic 5- fluorouracil (5- FU) and folinic acid (FA) bolus schedule [ irinotecan 180 mg/m(2) on day 1, 5- FU 500 mg/m(2) and FA 60 mg/m(2) on day 1 and 2 (FLIRI)] or the Lv5FU2 schedule [ irinotecan 180 mg/m(2) on day 1, FA 200 mg/m(2), 5- FU bolus 400 mg/m(2) and infused 5- FU 600 mg/m(2) on day 1 and 2 (Lv5FU2- IRI)] due to uncertainties about how to ad

Mitos, ciudades y cine: un viaje de ida y vuelta.

Myth, from the Greek mythos: “Mar-velous narration situated outside historic time told by divine or heroic characters. Often interprets the world’s origin or great human events”. The dragon, ex-cept for in China, has always been a symbol of “evil”, but, at the same time, the fire and power represented by the dragon are essential elements for hu-mankind. The modern city, symbolically under-stoo

Energy security under de-carbonization scenarios: An assessment framework and evaluation under different technology and policy choices

How would a low-carbon energy transformation affect energy security? This paper proposes a frame- work to evaluate energy security under long-term energy scenarios generated by integrated assessment models. Energy security is defined as low vulnerability of vital energy systems, delineated along geographic and sectoral boundaries. The proposed framework considers vulnerability as a combination of

De novo assembly of the dual transcriptomes of a polymorphic raptor species and its malarial parasite.

Studies of non-model species are important for understanding the molecular processes underpinning phenotypic variation under natural ecological conditions. The common buzzard (Buteo buteo; Aves: Accipitriformes) is a widespread and common Eurasian raptor with three distinct plumage morphs that differ in several fitness-related traits, including parasite infestation. To provide a genomic resource f

Positiv och negativ religionsfrihet i arbetslivet: När inskränker de på varandras områden?

Freedom of religion and its boundaries is a highly debated subject. Questions raised are how far the freedom of religion stretches and what restrictions there are for the manifestation of religious symbols such as the Sikh turban and the Muslim veil. Article 9 of the European Convention provides the right to freedom of thought, conscience and religion. Article 9 (1) states the meaning and extent

(DE)CONSTRUCTING SEXUALITY AND VIRGINITY AN ANTHROPOLOGICAL ANALYSIS OF SLIDKRANS IN SWEDEN

This thesis analyzes how the Swedish organization Riksförbundet för sexuell upplysning (in English, Swedish Association for Sexuality Education) constructs sexuality through the introduction of the word slidkrans. The word slidkrans (vaginal corona in English), was formally introduced by RFSU in 2009 as a replacement for the word for the hymen, mödomshinna, which literally means “virginity membran

St. Bridget's Revelations to the Popes. An edition of the so-called Tractatus de summis pontificibus

St. Bridget of Sweden was very much concerned about the decay and corruption of the Church. She had many revelations in which Christ and St. Mary appeared condemning abuses and bad practices. After St Bridget's death some of the revelations to and concerning popes were published by her Spanish confessor, Alfonso, former Bishop of Jaén. The present book gives an edition of the original Alfonsine co

De-centering state making : Comparative and international perspectives

Bridging the gap between international relations and comparative politics, this book transposes Eurocentric theories and narratives of state-making to new historical and geographical contexts in order to probe their scope conditions. In doing this, the authors question received explanations of the historical origins and geographical limits of state-making, questioning the unilinear view of the eme