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Thymic expression of insulin has been suggested to play a major role in negative selection of autoreactive T cells and tolerance induction against pancreatic beta cells. Furthermore, the expression of insulin in peripheral antigen-presenting cells (APC) has been clearly demonstrated but whether thymic negative selection and tolerance induction also depends on peripheral influx of self-antigens (Ag

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The prospects for patients suffering from systemic small vessel vasculitis have improved substantially in recent decades. The introduction of cyclophosphamide in the 1970s led to a dramatic improvement in survival rates. The discovery of ANCA meant a substantial increase in the number of detected cases, especially among elderly patients, as well as detection at an earlier stage of disease. At the

An analysis of the content of the treatise on the popes edited by Alfonso of Jaén.

Violaxanthin deepoxidase (VDE) has been purified from spinach (Spinacia oleracea) leaves. The purification included differential sonication of thylakoid membranes, differential (NH4)2SO4 fractionation, gel filtration chromatography and finally either hydrophobic interaction chromatography or anion exchange chromatography. A total purification of more than 5000-fold compared to the original thylako

A key premise of the heuristics-and-biases program is that heuristics are “quite useful.” Let us now pay more than lip service to this premise, and analyse the environmental structures that make heuristics more or less useful. Let us also strike from the long list of biases those phenomena that are not biases and explore to what degree those that remain are adaptive or can be understood as by-prod

This study is investigating the possibilities for the Indigenous Sámi People of Sweden to exercise their right to participate in, and influence, decision-making processes over land. The objective of the study is to investigate how Sámi rights are interpreted and applied within the institutional setting of municipalities, and within the planning process of land management. The study derives from tw

Deforestation monitoring is of significant importance for the ecosystem, climate change,and policy-making. The availability of optical and synthetic aperture radar (SAR) satellite remote sensing images, along with the development of time series change detection methods, has contributed to the increasing popularity of time series analysis in forest disturbance monitoring. However, there are few stu

In Italy, all aborted fetuses are required to be buried. However, when thousands of fetuses graves were found displaying a cross with the name of the person who had aborted, the practice was contested. The aim of this study is to examine the justifications behind the mobilization of the pro-life and pro-choice movements in Italy around the practice of the burial of aborted fetuses. Through the ana