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Injury to rat carotid arteries causes time-dependent changes in gene expression in contralateral uninjured arteries

Vascular surgery aimed at stenosis removal induces local reactions often leading to restenosis. Although extensive analysis has been focused on pathways activated in injured arteries, little attention has been devoted to associated systemic vascular reactions. The aim of the present study was to analyse changes occurring in contralateral uninjured rat carotid arteries in the acute phase following

Thrombospondin-4 mediates cardiovascular remodelling in angiotensin II-induced hypertension

Thrombospondin 4 (TSP-4) expression is induced in the heart and vasculature under pathological conditions, including myocardial infarction, myocardial pressure overload, and hypertension. TSP-4 is linked to remodelling processes, where it may affect extracellular matrix protein organization. In previous work, we studied the role of TSP-4 in small arteries during hypertension using Ang II-treated T

Suspending, believing, and truth telling : Reading Giorgio Agamben's pilate and Jesus with Bultmann and Foucault

In this article, Giorgio Agamben's essay Pilate and Jesus and in particular its notion of suspension as stalemate is treated as an important contribution to an ongoing exegetical conversation about the theological valence and event of John 18:28.19:41. In Agamben's essay, the suspension created by the dialogue between the Christ and the "Vicar of Caesar" demonstrates a peculiar stalemate of immane

Natural variability in exposure to fine particles and their trace elements during typical workdays in an urban area

Studies on the natural human exposures to fine particulate matter (PM2.5) and their elements composition are practically non-existent in South America. In order to understand the natural exposure of the typical Brazilian population to PM2.5 and their trace element composition, we measured PM2.5 concentrations and collected mass on filters for nine continuous hours during a typical workday of volun

You can't keep a good parasite down : Evolution of a male-killer suppressor uncovers cytoplasmic incompatibility

Maternally inherited parasites are known to impose a wide variety of reproductive manipulations upon their host. These often produce strong selection on the host to suppress the parasite, resulting in a reduction in the frequency of the parasite. However, in the butterfly Hypolimnas bolina, infected with a Wolbachia bacterium, field data demonstrate that suppression of the male-killing phenotype d

Effects of surface sorption on microbial degradation of glyphosate

Sorption may affect the bioavailability and biodegradation of pesticides in soils. The aim of this study was to test the effect of surface sorption on microbial utilization of the herbicide glyphosate as a source of phosphorus, nitrogen, or carbon. We added goethite to a humus soil to manipulate the soil's glyphosate sorption capacity. The addition of glyphosate generally either decreased microbia

Why Focus on Roles when Developing Future ERP systems

Abstract in UndeterminedIn this paper the question “Why software vendors focus on roles when they aim at developing the future enterprise resource planning (ERP) systems?” is discussed. At the moment there is increasing interest in developing ERP systems that support a person's different working roles in the organisation, which could be described as role-based ERPs. It could be asked whether this

DNA Extraction Protocols for Whole-Genome Sequencing in Marine Organisms

The marine environment harbors a large proportion of the total biodiversity on this planet, including the majority of the earths’ different phyla and classes. Studying the genomes of marine organisms can bring interesting insights into genome evolution. Today, almost all marine organismal groups are understudied with respect to their genomes. One potential reason is that extraction of high-quality

G protein-coupled receptor kinase 2-mediated phosphorylation of downstream regulatory element antagonist modulator regulates membrane trafficking of Kv4.2 potassium channel

Downstream regulatory element antagonist modulator (DREAM)/potassium channel interacting protein (KChIP3) is a multifunctional protein of the neuronal calcium sensor subfamily of Ca2+-binding proteins with specific roles in different cell compartments. In the nucleus, DREAM acts as a Ca2+-dependent transcriptional repressor, and outside the nucleus DREAM interacts with Kv4 potassium channels, regu

A method for extracting plant roots from soil which facilitates rapid sample processing without compromising measurement accuracy

This study evaluates a novel method for extracting roots from soil samples and applies it to estimate standing crop root mass (+/- confidence intervals) in an eastern Amazon rainforest. Roots were manually extracted from soil cores over a period of 40 min, which was split into 10 min time intervals. The pattern of cumulative extraction over time was used to predict root extraction beyond 40 min. A

Extension of nanoconfined DNA: Quantitative comparison between experiment and theory

The extension of DNA confined to nanochannels has been studied intensively and in detail. However, quantitative comparisons between experiments and model calculations are difficult because most theoretical predictions involve undetermined prefactors, and because the model parameters (contour length, Kuhn length, effective width) are difficult to compute reliably, leading to substantial uncertainti

Standardisation—the end of professional discretion?

This article analyses and discusses standardisation in human service organisations and its implications for professionals and for professionalism in social work. The theoretical framework derives from neo-institutional theory and theories regarding professionalism. By highlighting the role of professionals within a field influenced by organisational demands and market endeavour, this article contr

Bcl-3 and NF kappa B p50-p50 homodimers act as transcriptional repressors in tolerant CD4(+) T cells

The transcriptional events that control T cell tolerance are still poorly understood. To investigate why tolerant T cells fail to produce interleukin (IL)-2, we analyzed the regulation of NFkappaB-mediated transcription in CD4(+) T cells after tolerance induction in vivo. We demonstrate that a predominance of p50-p50 homodimers binding to the IL-2 promoter kappaB site in tolerant T cells correlate