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Adaptation and Learning for Manipulators and Machining

This thesis presents methods for improving the accuracy and efficiency of tasks performed using different kinds of industrial manipulators, with a focus on the application of machining. Industrial robots offer a flexible and cost-efficient alternative to machine tools for machining, but cannot achieve as high accuracy out of the box. This is mainly caused by non-ideal properties in the robot joint

Goniometer Crosstalk Compensation for Knee Joint Applications

Electrogoniometers are prone to crosstalk errors related to endblocks rotation (general crosstalk) and to the characteristics of each sensor (individual crosstalk). The aim of this study was to assess the crosstalk errors due to endblock misalignments and to propose a procedure to compensate for these errors in knee applications. A precision jig was used to simulate pure +/- 100 degrees flexion/ex

Mechanistic and Physiological Implications of the Interplay among Iron-Sulfur Clusters in [FeFe]-Hydrogenases. A QM/MM Perspective

Key stereoelectronic properties of Desulfovibrio desulfuricans [FeFe]-hydrogenase (DdH) were investigated by quantum mechanical description of its complete inorganic core, which includes a Fe6S6 active site (the H-cluster), as well as two ancillary Fe4S4 assemblies (the F and F' clusters). The partially oxidized, active-ready form of DdH is able to efficiently bind dihydrogen, thus starting H-2 ox

Synthesis of P1 '-Functionalized Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol

Seven novel tertiary alcohol containing linear HIV-1 protease inhibitors (PIs), decorated at the para position of the benzyl group in the P1' side with (hetero)aromatic moieties, were synthesized and biologically evaluated. To study the inhibition and antiviral activity effect of P1-P3 macro-cyclization, 14- and 15-membered macrocyclic Pis were prepared by ring-closing metathesis of the correspond

Evolutionary transitions in enzyme activity of ant fungus gardens

Fungus-growing (attine) ants and their fungal symbionts passed through several evolutionary transitions during their 50 million year old evolutionary history. The basal attine lineages often shifted between two main cultivar clades, whereas the derived higher-attine lineages maintained an association with a monophyletic clade of specialized symbionts. In conjunction with the transition to speciali

Pentamethylcyclopentadienyl-rhodium and iridium complexes containing (N^N and N^O) bound chloroquine analogue ligands: synthesis, characterization and antimalarial properties.

The synthesis and characterization of twenty new pentamethylcyclopentadienyl-rhodium and iridium complexes containing N^N and N^O-chelating chloroquine analogue ligands are described. The in vitro antimalarial activity of the new ligands as well as the complexes was evaluated against the chloroquine sensitive (CQS) NF54 and the chloroquine resistant (CQR) Dd2 strains of Plasmodium falciparum. The

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Christian theology is in favour of interreligious dialogue without proselytism. At the same time, all religious institutions do seem to have a drive to convert those who are not already inside. Hence there is a tension. Redefine the terms seems insufficient to me. The question to deal with is rather when, how, and why is conversion allowed or even praised even though the character of dialogue with

THE NETHERLANDS AND FOREIGN TRADE EMBODIED ENERGY: A DECOMPOSITION ANALYSIS OF STRUCTURAL AND TECHNICAL EFFECTS

This thesis examines whether there exists any causal relationship between foreign trade and declining energy intensity in the Netherlands. In other words, does the Netherlands outsource its energy intense industries to less developed countries rather than solve them internally? No significant causal relationships is found between international trade and declining energy intensity, since the Nether

ID2 expression in neuroblastoma does not correlate to MYCN levels and lacks prognostic value

The MYCN proto-oncogene is frequently amplified in a subgroup of highly aggressive neuroblastomas. The molecular mechanism(s) by which the overexpressed MYCN contributes to an aggressive tumor cell behavior is not well understood. Recently, it was reported that the ID2 gene is a direct target for the MYCN and MYC transcription factors, and that ID2 expression and MYCN amplification correlate posit

Removal of the fermentation by-product succinyl L-tyrosine from the beta-lactamase inhibitor clavulanic acid using a molecularly imprinted polymer

Clavulanic acid is a beta-lactamase inhibitor used in therapeutic combinations with the penicillin-type antibiotics. During the fermentation leading to clavulanic acid, a succinyl L-tyrosine by-product is unavoidably formed. Occasionally, the amount of this by-product is found to be as high as 2% of the product even after standard purification operations. To further remove this impurity, we prepar

Simultaneous release of hydrophobic and cationic solutes from thin-film "plum-pudding" gels: A multifunctional platform for surface drug delivery?

The release of two compositionally different solutes from a composite gel composed of two different populations of microgel particles embedded in a single bulk gel matrix is described, showing the potential of the "plum-pudding gel" as a multifunctional platform for controlled surface release. One hydrophobic solute (pyrene) and one hydrophobic and charged solute (rhodamine 123) were chosen as the

Medium och kommunikation - En studie om Det Okända

Problem Reality tv-programmet Det Okända har blivit kritiserat för att ha en tvivelaktig etik då de skapar underhållning av andras olycka, vi menar dock att ett program som Det Okända kan fylla en viktig funktion för sin publik. Vi anser att det är märkligt att tron på det ockulta och övernaturliga, ett hopp om liv efter döden, kan få människor att liknas vid enfaldiga individer utan verklighetsfö

Exklusiva varumärken - exklusivitetens krav

Alltfler människor har idag råd att unna sig något exklusivt och det finns en växande konkurrens på marknaden. Det finns därför också många böcker inom marknadsföring som talar om för företag hur de kan göra för att nå framgång med sina varumärken. Vårt syfte med denna uppsats är att titta på några av dessa teorier och att utifrån ett företagsperspektiv undersöka vilka faktorer i modern marknadsfö

Network Advantages in a Market Entry Context – A study of the Swedish fashion business

Purpose: The purpose of this paper is to research and analyze how the establishment in new markets of small and medium Swedish fashion companies can be made more efficient from a network perspective. Methodology: The researchers have decided to take a phenomenological standpoint and undertake an exploratory study in order to gain understanding of the phenomenon of market entry and the use of netwo