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ABSTRACT Radioimmunotherapy (RIT) consists of using monoclonal antibodies (mAbs) recognizing tumor-selective antigens, as carriers of cytotoxic radionuclides to tumor tissue. RIT has been effective in lymphoma but less successful in solid tumors. mAbs slowly diffuse from the vasculature into and through solid tumors, resulting in slow, limited accretion of antibodies. The outcome is a low tumor-to
Änkekejsarinnan Cixi styrde Kina under kejsardömets sista halvsekel. Hon utmålades länge som maktgalen och grym, men på senare tid har en mer nyanserad bild presenterats. I den här uppsatsen analyseras hur ett antal händelser i Cixis liv i relation till Guangxu-kejsaren och hans konkubin Zhenfei har beskrivits i olika källor. Syftet är att se vad dessa händelser säger om Cixi som person och om detEmpress Dowager Cixi governed China during the final five decades of the Qing dynasty. She was for many years depicted as a cruel megalomaniac, lately Cixi has been described in a more nuanced way. This paper seeks to analyze how a selection of sources describe a number of specific events in connection with Cixi and the Guangxu-emperor and his concubine Zhenfei. The objective is to discuss what th
Property rights systems and their relationship to the informal spaces are a contested and highly relevant part of contemporary development discourse. This study explores the reproduction of the concept of the informal in urban space. The central problematic of this study then departs by asking in what ways does the debate on property rights and the informal economy emerge as a representation of sp
Costa Rica has an important banana-producing industry that requires vast amounts of pesticides. These can leak into the environment and cause health effects. The most widely used pesticide is mancozeb, which is rapidly degraded to the carcinogenic and potentially groundwater-contaminating metabolite ETU. This study was executed in Matina, one of the most densely banana-cultivated areas of Costa Ri
The technological field can be seen as a huge advance for mankind before it emerged employers had to hire experts located in the same geographical area as the company. This changed with the introduction of information and communication technologies. Because of this, the labor market was able to become more global, meaning that employers do not need to hire employees who are physically close to the
ConspectusBy combining results and analysis from cylindrical microjet photoelectron spectroscopy (cMJ-PES) and theoretical simulations, we unravel the microscopic properties of ethanol-water solutions with respect to structure and intermolecular bonding patterns following the full concentration scale from 0 to 100% ethanol content. In particular, we highlight the salient differences between bulk a
The encapsulation of colloidal lead halide perovskite nanocrystals within silica (SiO2) is one of the strategies to protect them from polar solvents and other external factors. Here, we demonstrate the overcoating of CsPbBr3 perovskite nanocrystals with silica by exploiting the anhydride-induced transformation of Cs4PbBr6 nanocrystals. CsPbBr3@SiO2 core–shell nanocrystals are obtained after (i) a
We describe the dynamical evolution of a unique type of dark star cluster model in which the majority of the cluster mass at Hubble time is dominated by an intermediate-mass black hole (IMBH). We analysed results from about 2000 star cluster models (Survey Database I) simulated using the Monte Carlo code MOnte Carlo Cluster simulAtor and identified these dark star cluster models. Taking one of the
An orientation of a graph G is a digraph D obtained from G by replacing each edge by exactly one of the two possible arcs with the same endvertices. For each v∈V(G), the indegree of v in D, denoted by dD-(v), is the number of arcs with head v in D. An orientation D of G is proper if dD-(u)≠dD-(v), for all uv∈E(G). The proper orientation number of a graph G, denoted by χ→(G), is the minimum of the
Historical commons represent self-governed governance regimes that regulate the use and management of natural and man-made shared resources. Despite growing scientific interests, analyses of commons evolution and temporal dynamics are rare and drivers of change (birth, adaptation, dissolution) remain obscure. We apply an interdisciplinary approach and address these issues from an eco-evolutionary
With considerable flux in the peace and conflict landscape, scholars, policymakers, practitioners and publics alike are scrambling to understand emerging realities. Moreover, a sometimes slow academic publishing cycle means that much material appearing in academic journals seems already outdated–reporting on a peace and conflict landscape as though we are still in an era of comprehensive peace pro
Do personality traits in highly intelligent individuals relate to their work engagement? Seemingly little is known about the relationship between personality and work engagement for gifted individuals. In what may be the first study to do so, a Swedish Mensa sample (n = 353) was explored with a two-part aim: to assess psychometric personality properties and to investigate the relationship between
Pantomime is a means of bodily visual communication that is based on iconic gestures that are not fully conventional. It has become a key element in many models of language evolution and a strong candidate for the original human-specific communicative system (Zlatev et al. 2020). Although pantomime affords successful communication in many contexts, it has some semiotic limitations. In this study,
Infantile malignant osteopetrosis (IMO) is a fatal disease caused by lack of functional osteoclasts, and the only available treatment is hematopoietic stem cell (HSC) transplantation. In the majority of patients, the TCIRG1 gene, coding for a subunit of a proton pump essential for bone resorption, is mutated. Oc/oc mice have a deletion in the homologue gene (tcirg 1) and die at 3 to 4 weeks, but c
The present study examined plasma lipoprotein, lipoprotein lipase, hepatic lipase, and insulin levels in men with borderline hypertension (diastolic blood pressure 85 to 94 mm Hg) compared with age-matched normotensive control subjects (diastolic blood pressure less than or equal to 80 mm Hg, n = 75 + 75). High-density lipoprotein (HDL) subclasses were determined in a subset (n = 45 + 45). While t
374419_1_A3_DEVRES 2024 program.indd Conference Day 1 – 21 October 13.00 - 17.30 Venue: Auditorium 13.00-13.30 Moderated by Dr. Sara Gabrielsson, Lund University Conference welcome Opening ceremony: Miss Soraida Chindoy Buesaquillo, Resguardo Indigena , Condagua, Putumayo, Colombia Welcome addresses: Katarina Bjelke, Director General of the Swedish Research Council and Prof. Per Mickwitz, Vice Pri
https://www.lucsus.lu.se/sites/lucsus.lu.se/files/2024-10/374419_1_A4_DEVRES%202024%20program.pdf - 2026-06-08
BACKGROUND: Septic shock may cause splanchnic hypoperfusion. We hypothesized that levosimendan would improve systemic and hepatosplanchnic perfusion during endotoxemic shock. METHODS: In 16 anesthetized pigs (31.4 +/- 3.4 kg), a jugular vein, a carotid artery, the Pulmonary artery (thermodilution), the portal vein, and a hepatic vein were cannulated for hemodynamic monitoring and blood sampling. U
The objectives of the present study were to estimate long-term risks of osteoporotic fractures. The incidence of hip, distal forearm, proximal humerus and vertebral fracture were obtained from patient records in Malmo, Sweden. Vertebral fractures were confined to those coming to clinical attention, either as an inpatient or an outpatient case. Patient records were examined to exclude individuals w
Laminar burning velocities, S-L, of ethane + air and propane + air flames within an equivalence ratio range between 0.8 and 1.3 were determined at atmospheric and elevated pressures up to 4 atm. Measurements were performed in non-stretched flames, stabilized on a perforated plate burner at adiabatic conditions, created using the heat flux method. Initial unburnt gas temperature was 298 K. These ne
