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This Phase I study investigated the recommended Phase II dose (RP2D) of inotuzumab ozogamicin (InO), a CD22-directed antibody-drug conjugate, in pediatric patients with multiple-relapsed/refractory (R/R) CD22-positive acute lymphoblastic leukemia (ALL). Patients (≥1-<18 years) received three InO doses (Days 1, 8, 15) per course. Dose-escalation was based on dose-limiting toxicities (DLT) during Co

A match-action cut in feature films connects two shots of a single continuous movement. This type of editing often goes unnoticed and is arguably the most effective form of continuity editing. However, the literature offers little agreement on editing best practice and, by implication, on how our perceptual system deals with disjointed moving images. Studies have suggested that frames should overl

Besides reducing fuel demands and indoor air pollution, pyrolytic cooking stoves produce a by-product (biochar) that can improve soil fertility and serve as a sink for carbon sequestration. Most smallholder farmers in Africa depend on wood for fuel, suffer from exposure to smoke and soils in their cultivated farms are deteriorating. Biochar (bio-charcoal) production has potentials to reduce energy

This paper investigates the association between perinatal health and all-cause mortality for specific age intervals, assessing the contribution of maternal socioeconomic characteristics and the presence of maternal-level confounding. Our study is based on a cohort of 12,564 singletons born between 1915 and 1929 at the Uppsala University Hospital. We fitted Cox regression models to estimate age-var

The EC-Earth earth system model has been recently developed to include the dynamics of vegetation. In its original formulation, vegetation variability is simply operated by the Leaf Area Index (LAI), which affects climate basically by changing the vegetation physiological resistance to evapotranspiration. This coupling has been found to have only a weak effect on the surface climate modeled by EC-

In this paper the spectral features of impulse noise in DSL systems are mapped from the waveform domain onto the symbol domain, considering a QAM receiver. This work can be viewed as part of a full symbol domain model for impulse noise, which should include the amplitude and spectral aspects. Since the available models of impulse noise in DSL are generally waveform-based, this kind of mapping is j

According to film mythology, the Soviet filmmaker Lev Kuleshov conducted an experiment in which he combined a close-up of an actor’s neutral face with three different emotional contexts: happiness, sadness, and hunger. The viewers of the three film sequences reportedly perceived the actor’s face as expressing an emotion congruent with the given context. It is not clear, however, whether or not the

No abstract. Titel i svensk översättning: Jämförelse mellan Japan och Sverige.

Popular Abstract in Swedish Färger innehåller mer tillförlitlig information än vad bara skillnader i ljusintensitet gör. Det är därför inte svårt att förstå varför de allra flesta landlevande ryggradsdjur har färgseende. Några upplever en färgfattigare värld än vi människor, men många ser fler färgnyanser. På kvällen däremot gör bristen på ljus det svårt att se färger. Trots detta finns det nattakMost terrestrial vertebrates have colour vision, some perceive a less colourful world and others actually discriminate a wider colour spectrum than humans do. Still, we can all make use of the valuable colour information, which is more rigid than just brightness. However, at night when the light is dim, the lack of photons makes colour vision difficult. Nevertheless, some hawkmoths and bees can se

Det är nedslående att Cecilia Malmström givit upp kampen när det gäller fri- och rättigheter på nätet, skriver politiker och nätdebattörer. Den rättssäkerhet vi efterfrågar är en sådan som skyddar yttrandefriheten.

Field bio-remediation techniques (FBRT) can be a low cost method to avoid the removal of top layers of soil which are rich in organic matter and bio diversity. The use of native microorganisms in FBRT is preferable because non-indigenous species can transfer their genetic material to the environment with negative impacts on the local ecological equilibrium. Petroleum Produced Water (PPW) is an imp