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Background: Asthma genetics has been extensively studied and many genes have been associated with the development or severity of this disease. In contrast, the genetic basis of allergic rhinitis (AR) has not been evaluated as extensively. It is well known that asthma is closely related with AR since a large proportion of individuals with asthma also present symptoms of AR, and patients with AR hav

Introduction: In wood-dwelling fungus-farming weevils, the so-called ambrosia beetles (Curculionidae: Scolytinae and Platypodinae), wood in the excavated tunnels is used as a medium for cultivating fungi by the combined action of digging larvae (which create more space for the fungi to grow) and of adults sowing and pruning the fungus. The beetles are obligately dependent on the fungus that provid

Effects of the addition of a cationic amino acid-based synthetic amphiphile, arginine N-lauroyl amide dihydrochloride (ALA), to a lipid-based transfection formulation have been investigated. It is shown that the inclusion of ALA results in a substantial enhancement of the transfection capability of lipoplexes prepared with liposomes of 1-palmitoyl-2-oleoyl-sn-glycero-3-ethylphosphocholine and chol

Atypical hemolytic uremic syndrome (aHUS) emerged during the last decade as a disease largely of complement dysregulation. This advance facilitated the development of novel, rational treatment options targeting terminal complement activation, e.g., using an anti-C5 antibody (eculizumab). We review treatment and patient management issues related to this therapeutic approach. We present consensus cl

Context: Inflammation and adipogenesis are two parallel processes with increased activity in severe Graves' ophthalmopathy. Objective: The aim of this work was to define target genes for therapeutic intervention in adipogenesis and inflammation in Graves' ophthalmopathy. Design: Orbital tissue was obtained from patients with ophthalmopathy in acute or chronic phase undergoing orbital surgery to st

The aim of this study was to determine the threshold of fracture probability at which interventions become cost-effective. We modeled the effects of a treatment costing $500/year, given for 5 years, that decreased the risk of all osteoporotic fractures by 35%, followed by a waning of effect for 5 years. Sensitivity analyses included a range of effectiveness (10%-50%) and a range of intervention co

Popular Abstract in Swedish I december 1990 antog riksdagen i Sverige ett miljötillägg i skollagens s k portalparagraf: "Var och en som verkar inom skolan skall främja? respekt för vår gemensamma miljö." Alltså: Alla som verkar i skolan ska nu ta sig an den nya miljötematiken i samhället. Strax därefter tillsatte regeringen en ny läroplanskommitté med ett tydligt miljöuppdrag. I juni 1992, vid FNThis thesis explores the various influence processes that take place in connection with the dawn of a new theme - the environment - in today's society. Society has declared that schools, a place designed for the intentional influence of children and youths, shall utilise the new environmental theme in its practice. It focuses on the initiation process of the environmental theme in schools from the

Where medieval Denmark and Scandinavia as a whole has often been seen as a cultural backwater that passively and belatedly received cultural and political impulses from Western Europe, Professor Michael H. Gelting and scholars inspired by him have shown that the intellectual, religious and political elite of Denmark actively participated in the renaissance and reformation of the central and later

Following the recommendations drawn after the Commissioning Phase of the ENVISAT satellite in 2002, SCIAMACHY near real time data processors were upgraded to version 5.01 in early 2004. Before public release of the new SCIAMACHY nitrogen dioxide (NO2) vertical column data product, several validation teams investigated its improvement and assessed its geophysical consistency by means of correlative

The rationale for long-term prophylaxis in more severe forms of von Willebrand's disease (VWD) is obvious, as mucosal bleeding and haemophilia-like joint bleeds resulting in chronic morbidity may occur. However, the experience with prophylactic treatment in this group is scanty. An international VWD Prophylaxis Network (VWD PN) was established in 2006. The VWD PN will investigate prophylaxis with

The Heat Flux method was further developed to significantly reduce its experimental uncertainty and used to determine burning velocities under conditions when the net heat loss from the flame to the burner is zero. Non-stretched flames were stabilized on a perforated plate burner at 1 atm. Measurements of the adiabatic burning velocity of methane air flames at initial mixture temperatures of 318 K

Introduction. Limited information is available concerning the general and sexual health status of European men. Aim. To investigate the age-related changes in general and sexual health in middle-aged and older men from different countries of the European Union. Methods. This is a cross-sectional multicenter survey performed on a sample of 3,369 community-dwelling men aged 40-79 years old (mean 60

Glucagon, secreted from pancreatic islet a cells, stimulates gluconeogenesis and liver glycogen breakdown. The mechanism regulating glucagon release is debated, and variously attributed to neuronal control, paracrine control by neighbouring beta cells, or to an intrinsic glucose sensing by the a cells themselves. We examined hormone secretion and Ca2+ responses of a and b cells within intact roden

A general methodology for noise reduction and contrast enhancement in very noisy image data with low dynamic range is presented. Video footage recorded in very dim light is especially targeted. Smoothing kernels that automatically adapt to the local spatio-temporal intensity structure in the image sequences are constructed in order to preserve and enhance fine spatial detail and prevent motion blu

Popular Abstract in Swedish Områden som är kontinuerligt utsatta för vinderosion löper stor risk för att erhålla en försämrad jordkvalitet eftersom vinderosion innebär en utsållning av fina fraktioner och humus från jordmånen. För att vinderosion ska inträffa krävs en kombination av vissa väder- och markförhållanden. Flera av dessa är direkt relaterade till klimatet, t ex vindhastighet och jordfukWind erosion is a serious threat to soil resources as it causes depletion of the fine fractions that may result in a less fertile soil. Wind erosion encompasses several processes of which many are related to climate variables. To date, there is little work performed on how wind erosion relates to climate and climate change. In this thesis, atmospheric circulation and wind erosion were analysed to

A novel immunoassay (PINC-ELISA) was designed using proteinase inhibitors of the cystatin superfamily (PINC) in the solid phase, to promote the selective capture of cysteine proteinases. The method was applied in the identification of papain-like antigens from parasitic protozoa. PINC of human origin, namely recombinant cystatin C (r-cystatin C) or low molecular weight kininogen were used in the a

The Sheinwoodian succession of Gotland comprises the Högklint, Tofta and Hangvar Formations and most of the Slite Group. The succession consists of hierarchically ordered shallow marine depositional cycles, produced by orbitally forced climate changes. During warmer and wetter intervals (climate maxima) more carbonate was produced than during the cooler and dryer climate minima. Higher carbonate p

Popular Abstract in Swedish Syftet med denna undersökning är att diskutera inlärares signaler om hjälp att uttrycka sig på främmande språk, här franska, signaler som här kallas ?sollicitationer?. Undersökningen handlar om vilken roll dessa spelar för den fortsatta utvecklingen av samtalet med den infödde talaren, närmare bestämt för att utlösa s.k. SPA (Séquences Potentiellement Acquisitionnelles)The aim of this study is to discuss how ?soliciting? (non-native speakers? requests of native speakers for help in how to express themselves in a foreign language) may play a part in the triggering of SPAs (Séquences Potentiellement Acquisitionnelles or ?learning?teaching sequences?). The beneficial effect of SPAs for learning is still controversial, since no correlation has yet been shown between

Popular Abstract in Swedish Behandlingsideologier och arbetsmodeller avlöser varandra snabbt i dagens samhälle. Att hänga med i det nya och samtidigt försvara det arbete som man gör eller tidigare gjort är en problematik som allt fler ställs inför. I spelet mellan olika inriktningar byggs det upp en argumentation. I denna avhandling analyseras hur anställda vid en psykiatrisk vårdinstitution, specTreatment ideologies and working models replace each other quickly in today's society. During the 1980s a dramatic dismantling of the psychiatric institutions occurred. The health care system was supposed to be transferred to non-institutional care. This was, however, not possible for all groups of patients. At an institution, specialized in so called demanding patients and patients who received c