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Background and aims: The gastric hormone ghrelin has been reported to stimulate food intake, increase weight gain, and cause obesity but its precise physiological role remains unclear. We investigated the long term effects of gastrectomy evoked ghrelin deficiency and of daily ghrelin injections on daily food intake, body weight, fat mass, lean body mass, and bone mass in mice. Methods: Ghrelin wa
Annamirl and the Stove of Delight. With reference to "folk art" and "folk art" research in Europe.
We present new results for the inner valence levels of clusters of the three inert gases Ar, Kr and Xe based on photoelectron spectroscopy studies. The inner valence levels are compared to the localised core levels and to the delocalised outer valence levels. This comparison shows a gradual change from a relatively localised behaviour for Ar inner valence 3s, over the intermediate case of Kr inner
Autoantibodies against the newly established autoantigen in type 1 diabetes, zinc transporter 8, ZnT8, are presented as two types, ZnT8RAb and ZnT8WAb. The rs13266634 variant of the SLC30A8 gene has recently been found to determine the type of ZnT8Ab. The aim of this study was to explore the impact of this genetic variant and the ZnT8Ab on the residual beta-cell function during disease progression
Background and aims: “It’s best to start with air” states the current guidelines on the resuscitation of babies at birth. In a piglet model mimicking severe neonatal asphyxia and circulatory arrest, different aspects of resuscitation were investigated (studies I-III). The hypotheses were that the return of spontaneous circulation (ROSC) would occur faster with the use of oxygen (I and III) or adre
Many patients with asthma or chronic obstructive pulmonary disease (COPD) routinely receive a combination of an inhaled bronchodilator and anti-inflammatory glucocorticosteroid, but those with severe disease often respond poorly to these classes of drug. We assessed the efficacy and safety of a novel inhaled dual phosphodiesterase 3 (PDE3) and PDE4 inhibitor, RPL554 for its ability to act as a bro
Background: Systematic literature reviews and systematic mapping studies are becoming increasingly common in software engineering, and hence it becomes even more important to better understand the reliability of such studies. Objective: This paper presents a study of two systematic mapping studies to evaluate the reliability of mapping studies and point out some challenges related to this type of
Aims Angiotensin-converting enzyme inhibitors (ACE-Is) and beta-blockers are associated with improved outcome in patients with chronic heart failure (CHF). In this post hoc analysis of the CIBIS III trial, we examined the influence of the order of drug administration on clinical events and achieved dose. We also assessed the relations between dose levels and baseline variables or adverse events. M
Background Patients with gastrointestinal neuromuscular diseases may undergo operative procedures that yield tissue appropriate to diagnosis of underlying neuromuscular pathology. Critical to accurate diagnosis is the determination of limits of normality based on the study of control human tissues. Although robust diagnostic criteria exist for many qualitative alterations in the neuromuscular appa
The biosynthesis of flavonoids and proanthocyanidins was studied in cultivated strawberry (Fragaria x ananassa) by combining biochemical and molecular approaches. Chemical analyses showed that ripe strawberries accumulate high amounts of pelargonidin-derived anthocyanins, and a larger pool of 3',4'-hydroxylated proanthocyanidins. Activities and properties of major recombinant enzymes were demonstr
Background The methyl ester form of fumaric acid named dimethyl fumarate (DMF) is an effective mould-growth inhibitor. Its irritating and sensitizing properties were demonstrated in animal models. Recently, DMF has been identified as responsible for furniture contact dermatitis in Europe. Objective To describe the clinical manifestations, patch test results, shoe chemical analysis, and source of e
Many nitrosamines are suspected of being human carcinogens, with the highest concentrations in the environment being measured in the rubber industry. Time trends of personal exposure to N-nitrosodimethylamine (NDMA) and to N-nitrosomorpholine (NMor) during the past two decades in the German rubber industry were analysed and compared with cross-sectional studies in the same period in the Netherland
Wavelet approaches have been successfully applied to the detection of brain activity in fMRI data. Spatial activation patterns have a compact representation in the wavelet domain. However, classical wavelets designed for regular Euclidean spaces are not optimal for the topologically complicated gray-matter (GM) domain where activation is expected. We hypothesized that wavelet bases that are adapte
I samband med äktenskapsskillnad kan frågan om nyttjanderättsersättning aktualiseras om en av makarna tillsvidare bor kvar i en tidigare gemensam bostad. Då det i svensk rätt saknas lagstadgande om nyttjanderättsersättning syftar denna framställning till att klargöra rättsläget, genom att analysera framförallt praxis och doktrin. Avslutningsvis syftar framställningen till att diskutera om tillämpnA question of tenancies compensation can arise during a divorce, if one of two spouses re-mains settled in a former joint home. Due to the fact that Swedish law is missing enactment of this kind of compensation, the purpose of this depiction is to clarify the legal situation by analysing mainly established practice and doctrine. In the conclusion the author will discuss whether the regulations sho
På senare år har såväl nationalismen som populismen varit på framväxt i Europa. Dessa rörelser har kommit att få ett allt större politiskt inflytande i EU:s medlemsstater, med en påverkan på EU som institution som följd. I denna uppsats undersöks två av de sätt på vilka EU har påverkats av de politiska strömningarna i Europa: det påstådda rättssatsbrottet i Polen samt Storbritanniens potentiella uThere has been a surge in nationalism and populism in Europe. As these movements increasingly gain political influence in the Member States, the EU has been affected in several ways. This thesis will examine two of these instances: the alleged rule of law breaches in Poland and the probable fu-ture withdrawal of Britain from the EU. These situations are governed by Article 7 TEU and Article 50 TEU
Sammanfattning Grundläggande mänskliga rättigheter är ett växande rättsområde, vilket illustreras av den ökande andelen mål med grund i mänskliga rättigheter vid Europeiska domstolar. Denna utveckling, i kombination med att rättighetskatalogen utvidgas och att de befintliga rättigheterna får en mer extensiv tolkning innebär oundvikligen att även mål där två mänskliga rättigheter ställs emot varandSummary Fundamental rights are an expanding area of law, which is demonstrated by the increasing number of cases in European courts drawing upon fundamental rights provisions. This development in combination with the expanding rights catalogue and a more extensive interpretation given to existing rights inevitably also leads to an increase in conflicts between fundamental rights. This issue has ho
Antalet barn och unga som upplever könsdysfori har ökat drastiskt under det senaste årtiondet. Unga könsdysforiker har behandlats och behandlas idag med hormoner som kan bromsa pubertetsutvecklingen eller göra att kroppen utvecklas närmare till det könet som den unga identifierar sig som. Könsbe-kräftande hormonbehandlingar till barn har på senare tid väckt ett antal frågor, eftersom behandlingarnThe number of children and adolescents who experience gender dysphoria has increased rapid-ly over the past decade. Gender dysphoria in adolescence may be treated with hormones that either delay the onset of puberty or govern the gender development closer towards the gender that the patient identifies with. Hormonal gender-affirming treatments in children have recently been brought up to discussio
This thesis explores the relationship between French restrictive policies on the hijab and burqa and their impact on the human rights and fundamental freedoms of Muslim women. It likely delves into the historical context of these policies, analyses the legality and implications of such restrictions, and considers the broader sociocultural and political factors at play. It further examines the inte
