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BackgroundMultigene expression assays for molecular subtypes and biomarkers can aid clinical management of early invasive breast cancer. Based on RNA-sequencing we aimed to develop single-sample predictor (SSP) models for conventional clinical markers, molecular intrinsic subtype and risk of recurrence (ROR).MethodsA uniformly accrued breast cancer cohort of 7743 patients with RNA-sequencing data

This paper reports results of a production experiment in which nine native speakers of Tokyo Japanese read aloud sentences with varied syntactic structures, word orders, and levels of awareness of the syntactic structure. In particular, this study investigates the prosodic realization of embedded clause boundaries and potential effects of word order and readers’ awareness of the syntactic structur

The human brain performs tasks with an outstanding energy efficiency, i.e., with approximately 20 Watts. The state-of-the-art Artificial/Deep Neural Networks (ANN/DNN), on the other hand, have recently been shown to consume massive amounts of energy. The training of these ANNs/DNNs is done almost exclusively based on the back-propagation algorithm, which is known to be biologically implausible. Th

Flight behaviours of birds have been extensively studied from different angles such as their kinematics, aerodynamics and, more generally, their migration patterns. Nevertheless, much is still unknown about the daily foraging flight activity and behaviour of breeding birds, and potential differences among males and females. The recent development of miniaturized accelerometers allows us a glimpse

Background: Breast reconstruction after mastectomy helps women with breast cancer feel better about their bodies and lives. There is debate about the best time and type of reconstruction (immediate versus delayed, and using own tissue versus implants). Long-term studies are rare. Aim: This study looked at long-term results of different breast reconstruction methods and timings in Swedish women who

Background: Frozen section is a standard of care procedure during thoracic surgery when an immediate diagnosis is needed. An alternative procedure is intraoperative cytology. Video-assisted thoracic surgery is currently widely used for thoracic surgical procedures. The aim of this study was to assess intraoperative cytology together with frozen section for accuracy, turnaround time, and total resp

Motivated by the relevance of Pt clusters in heterogeneous catalysis, ordered Pt cluster superlattices are templated by the moiré of monolayer hexagonal boron nitride (h-BN) with Ir(111). Using X-ray photoelectron spectroscopy, scanning tunneling microscopy, and scanning tunneling spectroscopy, we provide a comprehensive picture for the mechanism of cluster binding, the thermal stability of cluste

Contributions in this thematic issue focus explicitly on citizens and their online engagement with European politics. For social media research in the European Union, citizens remain an understudied actor type in comparison with political elites or news organizations. The reason, we argue, is four key challenges facing social media research in the European Union: legal, ethical, technical, and cul

Recent work in cognitive science argues for the illusory nature of conscious will and considers occasional “blindness” to manipulations as indicative of our lack of awareness in choice making (e.g., Dennett, 1996; Johansson et al., 2013; Wegner, 2018). This claim is based upon the tendency of experimental participants not to detect such manipulations, and the similarity between verbal justificatio

Purpose: To examine associations of prenatal biomarkers of pesticide exposure with birth size measures and length of gestation among newborns from the Infants' Environmental Health (ISA) birth cohort, Costa Rica. Methods: We included 386 singleton liveborn newborns with data on birth size measures, length of gestation, and maternal urinary biomarkers of chlorpyrifos, synthetic pyrethroids, mancoze

Harvest residue management is a key issue for the sustainability of Eucalyptus plantations established on poor soils. Soil microbial communities contribute to soil fertility by the decomposition of the organic matter (OM), but little is known about the effect of whole-tree harvesting (WTH) in comparison to stem only harvesting (SOH) on soil microbial functional diversity in Eucalyptus plantations.

Objective Studies indicate that the functional outcome evolves in the year after ischemic stroke onset. However, the traditional outcome measure in stroke trials is the modified Rankin Scale (mRS) at 90 days from onset. To determine mRS fluctuations in the first year after stroke, we examined data from 3 major stroke trials.MethodsIn a secondary analysis, we evaluated intrapatient mRS between 90 d

This doctoral thesis in computational statistics utilizes both Monte Carlo methods(approximate Bayesian computation and sequential Monte Carlo) and machine­-learning methods (deep learning and normalizing flows) to develop novel algorithms for infer­ence in implicit Bayesian models. Implicit models are those for which calculating the likelihood function is very challenging (and often impossible),

Background: As the volume of surgical cases in low-and middle-income countries (LMICs) increases, surgical-site infections (SSIs) are becoming more prevalent with anecdotal evidence of antimicrobial resistance (AMR), despite a paucity of data on resistance patterns. Objectives: As a primary objective, this prospective study aimed to describe the epidemiology of SSIs and the associated AMR among wo

Microorganisms are important sources of diverse intracellular and extracellular biopolymers havingdifferent functions such as serving as carbon and energy reserves, or as protective layers around the cells in theform of capsules and/or biofilms. They have also found use in foods, medicine and other industrial applications.Research on understanding the synthesis of several biopolymers as well as th

Recent research on normal human tissues identified omnipresent clones of cells, driven by somatic mutations known to be responsible for carcinogenesis (e.g., in TP53 or NOTCH1). These new insights are fundamentally changing current tumor evolution models, with broad oncological implications. Most studies are based on surgical remnant tissues, which are not available for many organs and rarely in a