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Background: In adults and adolescents with asthma, use of ≥3 short-acting β2-agonist (SABA) canisters/year is associated with increased exacerbation risk. Whether this association is present in younger children remains unknown. In this SABA use IN Asthma (SABINA) Junior study, we assessed the association of SABA collection with exacerbation risk in the general Swedish pediatric asthma population.
Objective: To report methodology and first-year results of a new educational project called Televascular Games,” which took place during coronavirus disease 2019 pandemic. Methods: Complex aneurysmal aortic disease was discussed during a 2-hour competition webinar, according to three modalities. (1) Planning case competition (PCC): Two to four preoperative computed tomography angiography (CTA) sca
Rapid technological improvements are democratizing access to high quality, chromosome-scale genome assemblies. No longer the domain of only the most highly studied model organisms, now non-traditional and emerging model species can be genome-enabled using a combination of sequencing technologies and assembly software. Consequently, old ideas built on sparse sampling across the tree of life have re
Monocytes are key players in innate immunity, with their ability to regulate inflammatory responses and combat invading pathogens. There is a growing body of evidence indicating that long non-coding RNA (lncRNA) participate in various cellular biological processes, including the innate immune response. The immunoregulatory properties of numerous lncRNAs discovered in monocytes remain largely unexp
C4b-binding protein (C4BP) is an important component in the regulation of the complement system and also binds the anticoagulant vitamin K-dependent protein S. These activities are performed by distinct, although structurally related, polypeptides of 70 kDa (alpha chain) and 45 kDa (beta chain), respectively. In this report we have investigated the genetic relationships between these polypeptides.
Activation of the kynurenine pathway (KP) has been reported in patients with pulmonary arterial hypertension (PAH) undergoing PAH therapy. We aimed to determine KP-metabolism in treatment-naïve PAH patients, investigate its prognostic values, evaluate the effect of PAH therapy on KP-metabolites and identify cytokines responsible for altered KP-metabolism. KP-metabolite levels were determined in pl
Tvister gällande kommersiella entreprenader har historiskt sett avgjorts genom skiljeförfaranden och är därtill undantagna från köplagens tillämpningsområde. Under en lång period har entreprenadrätten varit nästintill frikopplad från den allmänna avtalsrätten. Emellertid har andelen tvister som tagits upp i allmän domstol och som sedermera nått ett avgörande i Högsta domstolen ökat under de senastHistorically, construction contract law has been litigated through arbitration, and it is excluded from the scope of the Sale of Goods Act. For a long period of time, construction contact law has nearly been disconnected from general contract law. However, the proportion of litigations raised in general court and subsequently reaching a judicial decision in the supreme court, has increased in rece
Trots en sedan länge pågående debatt i doktrinen har både 1905 års köplag och dagens köplag tillämpats på företagsförvärv som sker genom en aktieöverlåtelse. Det är dock tydligt att lagstiftaren inte hade företagsförvärv eller aktieköp i åtanke när köplagen skrevs och reglerna tenderar därför att vara mindre lämpliga för aktieöverlåtelser vid företagsförvärv. I många situationer blir detta inget pDespite a long-standing debate in the doctrine, both the 1905 Swedish Sales of Goods Act and the current Swedish Sales of Goods Act have been applied to company acquisitions through share transfers. However, the legislator did not have company acquisitions or share purchases in mind when drafting the Sales of Goods Act and the set of rules therefore tends to be less suitable for share transfers in
In 2023 an operator theoretic approach to the Prime Number Theorem was introduced by Olsen. In this thesis this approach is examined and applied to give a new, operator theoretic, proof of a different version of the Prime Number Theorem and of the Prime Number Theorem for arithmetic progressions. This approach is then expanded and rearranged to focus on the approximation error in the Prime Number
Med hjälp av koncernbidrag, vilket kan ges mellan koncernbolag, uppnår svenska företagsgrupper en utjämning av sina resultat. Att ge koncernbidrag är möjligt bara mellan helägda dotterbolag. Med helägt menas i detta fall att moderbolaget måste äga dotterbolaget till mer än 90 procent. Det uppställs alltså ett så kallat ägandekrav för moderbolaget. Genom aktuell praxis, främst HFD 2021 ref. 66 har Through group contribution Swedish groups can equalize the results of their companies. Giving such contributions is only possible in fully owned groups. The parent company has to own more than 90 percent of the shares in its subsidiary. This is a so called ownership requirement for the parent company. The Swedish supreme administrative court has opened up for a possibility to avoid this ownership
This thesis project explores the significance of public spaces in shaping society, culture, and individual identity, emphasizing their role in promoting democratic values and self-realization. Public spaces, such as squares and marketplaces, serve as platforms for social interaction, economic activity, and cultural continuity. The design of these spaces reflects societal values and historical cont
Understanding the interplay between human brain structure and function is crucial to discern neural dynamics. This study explores the relation between brain structure and macroscale functional activity using subject-specific structural connectome eigenmodes, complementing prior work that focused on group-level models and geometry. Leveraging data from the Human Connectome Project, we assess accura
Comprehensive epigenomic studies in multiple myeloma (MM) that unravel the connections between major epigenetic regulators, their intertwined collaboration and the potential of combinatorial targeting remain limited. Utilizing ChIP-seq, ATAC-seq, RNA-seq, and DNA methylation (DNAme) data, we generated whole-genome chromatin annotations from normal plasma cells and MM patients, revealing epigenomic
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder marked by β-amyloid (βA) accumulation, neuroinflammation, excessive synaptic pruning, and cognitive decline. Despite extensive research, effective treatments remain elusive. Here, we identify potassium channel-interacting protein 3 (KChIP3) as a key driver of AD pathology using the 5XFAD mouse model. KChIP3 levels were significan
Introduction: Myocarditis is a complex cardiac disorder with multifactorial etiology, characterized by myocardial inflammation, cardiomyocyte damage, and fibrosis. Left untreated, myocarditis may lead to acute and chronic heart failure and life-threatening arrhythmias. Reliable experimental models of myocarditis are required to study the underlying pathological mechanisms of the disease and to dev
Multiple cropping, the simultaneous cultivation of several crops in space or time, is a global practice essential for intensifying and diversifying agriculture. Despite its substantial impact on environmental and socioeconomic outcomes of farming, multiple cropping is hardly accounted for in assessments of global food production, sustainability, and climate impacts. Such studies, often relying on
Dr Lisbeth NilssonLearning objectives:1. Discover how and why technology can enable non-mobile infants and children in developing tool-use and participation with the world.2. Explain how and why experiences of self-produced movement in a powered device can impact on very young infants’ overall development3. Motivate provision of opportunities to explore and experience powered mobility to very youn
The chemical industry must undergo a dual transformation: electrifying energy use and defossilizing carbon feedstocks. This paper, developed by ENGIEs Scientific Council, examines how energy and chemistry can converge to enable this shift. We assess the roles of biomass, recycled plastics, and CO2 as sustainable carbon sources and explore the enabling potential of electrification, low-carbon hydro
Propagation of intense X-ray pulses through dense media has led to the observation of phenomena such as atomic X-ray lasing1,2, self-induced transparency3 and stimulated X-ray Raman scattering (SXRS)4. SXRS has been long predicted as a means to launch and probe valence-electron wavepackets and as a building block for nonlinear X-ray spectroscopies5,6. However, experimental observations of SXRS to
