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Popular Abstract in Swedish Malignt melanom (även kallad melanom) är den farligaste formen av hudcancer. Dess incidens varierar från land till land och är den högsta i Australien, där 46.7 per 100,000 invånare drabbas årligen. I Sverige är melanom den sjätte vanligaste cancersjukdomen. Melanom har blivit allt vanligare under de senaste två decennierna. Om tumören upptäcks på ett tidigt, dvs. lokal“Cutaneous melanoma is a most unpredictable lesion” wrote Alexander Breslow in 1970. He was one of the first to predict outcome in melanoma patients, based on the thickness of the primary tumor, and today this parameter bears his name and remains the main prognostic factor in melanoma. The aim of this thesis has been to contribute to the understanding of melanoma biology in order to make this canc

This manuscript presents the digital hardware realization of a wavelet based event detector for cardiac pacemaker applications. The architecture of the detector is partially folded to minimize hardware cost. An energy model is applied to evaluate the energy efficiency the sub-threshold (sub-VT ) domain. The design is synthesized in 65nm low leakage-high threshold CMOS technology, and it is shown t

This thesis project explores the significance of public spaces in shaping society, culture, and individual identity, emphasizing their role in promoting democratic values and self-realization. Public spaces, such as squares and marketplaces, serve as platforms for social interaction, economic activity, and cultural continuity. The design of these spaces reflects societal values and historical cont

Uppsatsen behandlar ett folks självbestämmanderätt samt möjligheten till utträde i en demokratisk kontext. Den redogör i synnerhet för situationen mellan Québec och Canada. För att uppnå syftet utgår uppsatsen från frågeställningar angående (1) relationen mellan Québec och Canada i ett historiskt samt nutida perspektiv, (2) innebörden av rätten till självbestämmande inom folkrätten, (3) möjligheteThis thesis examines the right of a people to self-determination and the possibility of secession in a democratic context, focusing on the Québec-Canada case. To that end, it studies (1) the historic and contemporary relationship between Québec and Canada, (2) the meaning of the right to self-determination within international law, (3) possibilities for unilateral secession, and (4) secession by v

The tight junction protein claudin-4 has been reported to be overexpressed in advanced ovarian cancer. We investigated the prognostic significance of claudin-4 overexpression and whether claudin-4 expression could predict platinum response in primary ovarian carcinoma (OC). Claudin-4 expression was evaluated by immunohistochemistry in a tissue microarray of 140 OCs. Multivariable Cox-regression mo

Here we report a case of an 11-year-old girl with an inoperable tumor in the optic chiasm/hypothalamus, who experienced several tumor progressions despite three lines of chemotherapy treatment. Routine clinical examination classified the tumor as a BRAF-negative pilocytic astrocytoma. Copy-number variation profiling of fresh frozen tumor material identified two duplications in 9q21.32-33 leading t

Anthropogenic activities such as intensification of agriculture, animal husbandry and expansion of cities can negatively impact wildlife through its influence on the availability of high-quality food resources and pathogen transmission. The house sparrow (Passer domesticus), an urban exploiter, is undergoing a population decline. Nutritional constrains and infectious diseases has been highlighted

A mid-century net zero target creates a challenge for reducing the emissions of emissions-intensive, trade-exposed sectors with high cost mitigation options. These sectors include aluminium, cement, chemicals, iron and steel, lime, pulp and paper and petroleum refining. Available studies agree that decarbonization of these sectors is possible by mid-century if more ambitious policies are implement

Body dysmorphic disorder (BDD) often starts in childhood, with most cases developing symptoms before age 18. Yet, BDD research has primarily focused on adults. We report the clinical characteristics of the world’s largest cohort of carefully diagnosed youths with BDD and focus on previously unexplored sex and age differences. We systematically collected clinical data from 172 young people with BDD

Background: Treatment guidelines recommend behaviour therapy (BT) for patients with Tourette syndrome (TS) and chronic tic disorder (CTD). However, BT is rarely accessible due to limited availability of trained therapists and long travel distances to specialist clinics. Internet-delivered BT has the potential of overcoming these barriers through remote delivery of treatment with minimal therapist

The response rate to checkpoint inhibitors for women with high-grade serous carcinoma of the ovary, fallopian tube, and peritoneum (HGSC) is modest, and development of predictive biomarkers is needed. The main focus has been on tumor cell PD-L1 expression, but its assessment alone is insufficient for patient selection in most malignancies. We mapped the presence of macrophages (CD68 and CD163) and

Background: Body dysmorphic disorder (BDD) is thought to be associated with considerable suicide risk. This nationwide cohort study quantified the risks of intentional self-harm—including nonsuicidal self-injuries and suicide attempts—and death by suicide in BDD. Methods: Individuals with a validated ICD-10 diagnosis of BDD in the Swedish National Patient Register, registered between January 1, 19

Body dysmorphic disorder (BDD) is a prevalent and impairing psychiatric condition that typically debuts in adolescence and is associated with risky behaviours. The disorder can be effectively treated with cognitive behaviour therapy (CBT). However, CBT for BDD is seldom available primarily due to a shortage of trained therapists. Internet-delivered CBT (ICBT) can be a way to increase treatment ava

This short report is one of a series of outputs to flow from the international,interdisciplinary project ‘Looking back to move forwards: a social and cultural historyof home heating’ (JUSTHEAT), funded through the Collaboration of Humanities andSocial Sciences in Europe (CHANSE) initiative, which began in 2022 and runs until2025. Within this project, we aim to understand how major changes to home

Neonicotinoids, systemic insecticides that are distributed into all plant tissues and protect against pests, have become a common part of crop production, but can unintentionally also affect non-target organisms, including pollinators. Such effects can be direct effects from insecticide exposure, but neonicotinoids can affect plant physiology, and effects could therefore also be indirectly mediate

The transcription factor SOX2 is a well-established and important stem cell marker. Its role in cancer biology remains unclear, but it has been proposed to also be a marker of cancer stem cells. We investigated the role of SOX2 protein expression in women with high-grade serous ovarian cancer (HGSOC) to determine its potential prognostic and treatment predictive value. We constructed a tissue micr

Objective: Pre-clinical studies have identified marker- and tumor compartment-defined functionally distinct macrophage subsets. Our study analyzes marker-defined macrophage subsets in different tumor compartments of high-grade serous ovarian cancer (HGSC). Methods: A discovery cohort (N = 113) was subjected to immunohistochemistry (IHC) analyses. CD68-positivity was confirmed for CD11c-, CD80- and

Cluster superlattice membranes consist of a two-dimensional hexagonal lattice of similar-sized nanoclusters sandwiched between single-crystal graphene and an amorphous carbon matrix. The fabrication process involves three main steps, the templated self-organization of a metal cluster superlattice on epitaxial graphene on Ir(111), conformal embedding in an amorphous carbon matrix, and subsequent li