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Antibiotics are crucial in treating infectious diseases, particularly in intensive care unit patients, but they can lead to side effects such as ototoxicity. A mechanism for this is antibiotics targeting mitochondrial components in eucaryotic cells, due to their resemblance of those in bacteria. Here we investigate how five classes of antibiotics (carbapenems, fluoroquinolones, aminoglycosides, gl

Anticipation entails contemplating the beneficial and harmful impacts of scientific and technological progress. Anticipation has a long history in science, technology, and innovation policy partly due to future impacts of scientific progress being inescapable. The link between anticipation, an undertheorized concept, and human rights law is yet to be fully explored. This paper links anticipation t

In an article in this journal, Katherine Drabiak argues that green lighting genome editing of human embryos is contrary to "fundamental human rights law." According to the author, genome editing of human embryos violates what we should recognize as a fundamental human right to inherit a genome without deliberate manipulation. In this reply article, we assess Drabiak's legal analysis and show metho

This paper investigates resilient performance of Air Traffic Management with future Artificial Intelligence (AI)-based tools. A case study was performed on an early prototype of an AI-enabled Flight Information Service (FIS) tool, using a survey of flight instructors and air traffic controllers, and a focus group with controllers with flying experience. The study focused on what characterizes good

Spontaneous symmetry breaking, driven by nonadiabatic electron-nuclear coupling, can lead to geometric com plexity in molecules and solids. While structural distortion from symmetry breaking occurs in femtoseconds, the timescale to lift electronic state degeneracy has remained elusive. We use the vibrationally resolved attosecond chronoscope to capture the electronic symmetry breaking induced by t

Attosecond photoelectron interferometry, based on the measurement of photoelectron spectra generated by a two-colour field, provides access to the photoionisation dynamics of quantum systems. In general, due to the entanglement between the wave function of the emitted photoelectron and that of the parent ion, the dynamics driven by the infra-red field in the photoion can affect the properties of t

Axonal injuries commonly contribute to poor functional outcomes following traumatic brain injury (TBI). To assess cerebral blood flow (CBF) and energy metabolic disturbances in a TBI model of widespread axonal injury, we exposed 105 adult mice to the central (midline) fluid percussion injury (cFPI) diffuse TBI model, or sham injury, and used 9.4 T magnetic resonance (MR) arterial spin labeling (AS

Despite the centrality of economic theories (including political economic theories) in human geographic research, there is a massive shortage of courses covering this topic in many human geography departments. In this paper, we use the example of a third-semester elective MSc course in political economic theory designed for students in human geography to contribute to this point. The course aims t

AIM: Right ventricular (RV) function determines symptom burden and clinical outcomes in pulmonary hypertension (PH). Global wasted work (GWW) quantifies mechanical inefficiencies in RV performance associated with elevated afterload, but is inadequately characterized in precapillary PH. We assessed the association of GWW with echocardiographic indices of RV remodeling, RV-PA coupling and invasive h

This thesis combines quantitative, qualitative, and experimental approaches to address different aspects of distal radius fractures (DRFs) in the elderly.Study I was a registry-based cohort study of 5,536 DRF patients, of whom 259 (5%) sustained a concomitant distal metaphyseal ulna fracture. These patients, with a mean age of 73 years (SD 15), had nearly twice the odds of reporting severe symptom

Wheat (Triticum aestivum L.) is a major crop grown on all continents. Due to environmental concerns, it is desirable to reduce the inputs of both chemical pesticides and inorganic fertilizers. However, yield reduction must be expected when switching to low-input systems. To mitigate such losses, the use of natural or introduced microbiomes may provide the key to maintaining sustainable yield. Phyl

Introduction: Proactive and easily accessible interventions are needed to support people with long-term health conditions who experience limitations in activities of everyday life. However, there is a lack of interventions that promote self-management skills that prevent deterioration and improve health. The internet-based programme 'Strategies for Empowering Activities in Everyday Life' (SEE) sup

This paper proposes a conceptual model of decision-making tying specific preferences to broader individual goals. Specifically, we consider terminal goals, representing fundamental objectives, and instrumental goals, serving as complexity-reducing intermediate steps toward achieving terminal goals and determining eventual preferences. Notably, the hierarchical goal structure allows for contextual