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Messenger RNA (mRNA) vaccines based on lipid nanoparticles (LNPs) are stabilized with cholesterol, which is thought to be a critical LNP component because it is essential for membrane integrity and endosomal escape. Here, it is shown that cholesterol in LNPs can be replaced with an immunopotentiating lipid, i.e., a synthetic analogue of the C-type lectin receptor agonist monomycoloyl glycerol (MMG
Distributed multiple-input multiple-output (MIMO), also known as cell-free massive MIMO, has emerged as a promising technology for sixth-generation (6G) wireless networks. This letter introduces an indoor channel measurement campaign designed to explore the behavior of multipath components (MPCs) in distributed MIMO channels. Fully coherent channels were measured between eight distributed uniform
The rapid advancement of medicine, fueled by big data and interdisciplinary research, has significantly transformed the landscape of computational oncology research. In this evolving environment, effective time management strategies are essential for researchers across diverse specializations. Computational oncology researchers typically pursue one of three primary career paths: clinical medicine,
Αποτελεί η Κίνα κομμάτι του κόσμου;Αυτή η ερώτηση, παρά τον φαινομενικά ρητορικό της χαρακτήρα, αντικατοπτρίζει μια βαθιά ριζωμένη αντίληψη που κυριαρχεί σε μεγάλο μέρος του πολιτικού, δημοσιογραφικού και δημόσιου λόγου στη Δύση: ότι η Κίνα αποτελεί το «θεμελιωδώς διαφορετικό Άλλο», αποκομμένο από τον «πραγματικό» κόσμο. Παρά τη σαραντάχρονη ενσωμάτωσή της στο παγκόσμιο κοινωνικοοικονομικό σύστ
Poor acoustic conditions in learning spaces have a detrimental effect on the speaker's health and constitute a risk factor for voice disorders. Previous research indicates that an acoustic refurbishment of the learning space has the potential to increase well-being and decrease voice-related health problems among teachers, but the research is scarce. In this study, we aim to investigate how differ
In the last three field seasons the Geological Survey of Denmark and Greenland (GEUS) has undertaken mapping in the south-eastern part of the Nuuk region in southern West Greenland, and here we present new zircon ages that help constrain the northern boundary of the Tasiusarsuaq terrane. The Archaean geology of the Nuuk region is commonly interpreted as a tectonic collage assembled through lateral
The classical Chinese poem Mulan Shi has been translated many times into different languages and adapted to different media. Drawing upon Sonesson’s definition of translation as a double act of communication and combining it with concepts from narratology and translation theory, we develop a framework comprising three levels of translation resemblance: (a) between the structure and content of the
The concept of scattering contrast is central to (small-angle) scattering of neutrons, X-rays, and visible light, as it defines the visibility to the radiation of the nano- and mesostructures under scrutiny, in their respective solvent or matrix. In this chapter, we start with the scattering process by elementary scatterers, such as nuclei or atoms, which produce secondary, scattered waves, and th
Illegal, unreported, and unregulated (IUU) fishing poses a serious threat to marine biodiversity and economic stability, particularly in coastal nations like Malaysia, where the smuggling of government-subsidized fuel is often linked to IUU activities. This study presents a forensic approach using gas chromatography-flame ionization detection (GC-FID) and gas chromatography-mass spectrometry (GC–M
Tonalite-trondhjemite–granodiorite (TTG) gneisses and melanocratic to ultramafic greenstones dominate the Archaean basement of southern West Greenland. The greenstones are likely to represent different original environments, which is important as the mineral deposits they may host depend on this. For example, massive sulphide deposits associated with gold and base metals are commonly volcanogenic,
The extensive and very deep ?Jurassic/Cretaceous–Palaeogene sedimentary basins offshore West Greenland have a significant petroleum exploration potential. This is particularly true for the offshore region west of Disko and Nuussuaq where a live petroleum system has been documented for many years. At present, stratigraphic knowledge in this area is almost nonexistent and analogue studies from onsho
During the field campaign in the Nuuk region, one of the objectives was to describe Archaean primary geological environments (Hollis et al. 2006). On Nunatak 1390, which is part of the Tasiusarsuaq terrane (Figs 1, 2), a bimodal volcanic succession is preserved and interpreted as former ocean floor. The field investigation included geological mapping and sampling of the volcanic sequence comprisin
The 7Be(d, α)5Li and 7Be(d, p)8Be*(p 7Li) reactions are studied at 5 MeV/u in the context of the cosmological lithium problem. This work aims to probe the contribution of 7Be destruction mechanisms, particularly through channels that populate intermediate unbound states of 5Li and 8Be. The contribution of 7Be(d, α)5Li(p α) reaction is separated from the 7Be(d, p)8Be*(2α) reaction. The 7Be(d, p)8Be
Anthropogenic noise and artificial light at night (ALAN) are expanding globally, acting as pervasive sensory pollutants that can disrupt wildlife behaviour and reproduction. While most research has focused on diurnal species, the effects of these pollutants on the ecological response of nocturnal predators remain poorly understood. Using data from nine European countries, we investigated the effec
Losses and damages are residual impacts of climate change that occur despite mitigation and adaptation actions. Losses and damages are borderless, albeit experienced differently between and within countries. Although Australia is a high-income country, recent losses and damages have been particularly severe. Over the last eight years, farmers in East Gippsland, Victoria, have been severely affecte
We present the first ever dataset of manually segmented and transcribed Ajami manuscripts written in Fulfulde and Hausa. The term Ajami refers to modified Arabic-script orthographies in Africa. Existing handwritten text recognition (HTR) and optical character recognition (OCR) models for Arabic-script languages perform poorly on West African manuscripts due to a lack of these manuscripts represent
Estuaries are complex environments rich in biodiversity, making it challenging to understand the distribution and occurrence of microplastics due to the multiple variables that can influence the movement of these particles. Based on this, this study evaluated the influence of different environmental aspects on the distribution and transport of microplastics in the surface waters of the Tramandaí R
Complexity and innovation are emerging as fundamental issues for the future of human life and society. To deal with them, different versions of systems thinking have been proposed. However, System-of-Systems (SoS) thinking, based on the biperspectival principle and human reflexivity, has not yet been clearly recognized. The unclear distinction between ‘systems’ and ‘SoS’ thinking often results in
This study investigates the effects of high-frequency temporal light modulation (TLM) on neural activity using functional magnetic resonance imaging (fMRI) in healthy individuals (age 18–50 years). We examined stimulation frequencies both below (50 Hz) and above (≥100 Hz) the perceptible threshold for visual flicker. Our findings revealed that 50 Hz TLM, which is perceived as flickering, leads to
Multiple myeloma (MM) is the second most common blood malignancy, with several lines of evidence supporting an inherited genetic component. Here, we sequenced 177 affected individuals from 128 families, and 170 early-onset MM cases diagnosed before 55 years of age. Samples were identified and collected through nationwide efforts in France, Sweden, and Greece. We focused on rare germline protein tr
