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AlphaFold can predict the structures of monomeric and multimeric proteins with high accuracy but has a limit on the number of chains and residues it can fold. Here we show that a combination of AlphaFold and all-atom symmetric docking simulations enables highly accurate prediction of the structure of complex symmetrical assemblies. We present a method to predict the structure of complexes with cub
INTRODUCTION: We sought to determine structural magnetic resonance imaging (MRI) characteristics across subgroups defined based on relative cognitive domain impairments using data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and to compare cognitively defined to imaging-defined subgroups. METHODS: We used data from 584 people with Alzheimer's disease (AD) (461 amyloid positive, 123
In the Scandinavian Caledonides, evidence of syn-collisional magmatism related to extensional basin development immediately prior to late Silurian Baltica-Laurentia collision was considered restricted to exotic terranes until late Silurian ages were obtained from the Halti Igneous Complex (HIC), hosted by a thrust sheet (Corrovarre Nappe, CN) of continental affinity. Various orogenic models for th
BACKGROUND: The significant role of long non-coding 7S RNA in controlling mitochondrial transcription highlights its importance in mitochondrial function. Considering the suggested connection between mitochondrial dysfunction and the onset of mental disorders, this study aimed to explore the potential involvement of 7S RNA in the context of depression/anxiety.RESULTS: A total of 181 patients in pr
This short paper explores building innovation platforms in the public sector, particularly in public healthcare, through an ecological lens. While existing research has mainly focused on the platform owner's role in orchestrating innovation, this study investigates the strategies used by public organizations and widens the net to analyse how a digital health platform’s complementing actors contrib
Covid-19 has caused great challenges to the energy sector, particularly in residential buildings with low-income households. This study investigates the impact of the confinement measures due to the Covid-19 outbreak on the energy demand of seven residential archetype buildings in Greater London. Three levels of confinement for occupant schedules are proposed and compared with the base case before
The ECG diagnosis of LVH is predominantly based on the QRS voltage criteria. The classical paradigm postulates that the increased left ventricular mass generates a stronger electrical field, increasing the leftward and posterior QRS forces, reflected in the augmented QRS amplitude. However, the low sensitivity of voltage criteria has been repeatedly documented. We discuss possible reasons for this
A common misperception among non-arctic residents is that northern environments are less productive and more hostile to human life than other biomes; after all, it is true that in most arctic regions, traditional agriculture is generally not possible, and species richness is relatively low. Combatting such misperceptions is important because while the past century has foisted many traumatic change
Amyloid β peptide (Aβ) is the crucial protein component of extracellular plaques in Alzheimer’s disease. The plaques also contain gangliosides lipids, which are abundant in membranes of neuronal cells and in cell-derived vesicles and exosomes. When present at concentrations above its critical micelle concentration (cmc), gangliosides can occur as mixed micelles. Here, we study the coassembly of th
We experimentally explore the role of institutions imposing collective sanctions in sustaining cooperation. In our experiment, players only observe noisy signals about individual contributions in finitely repeated public goods game with imperfect monitoring, while total output is perfectly observed as it is often the case in collective action problems in society. We consider sanctioning mechanism
The emergence of sixth-generation (6G) networks has spurred the development of novel testbeds, including sub-THz networks, cell-free systems, and 6G simulators. To maximize the benefits of these systems, it is crucial to make the generated data publicly available and easily reusable by others. Although data sharing has become a common practice, a lack of standardization hinders data accessibility
Electric Road Systems, that allow electric vehicles to charge while driving, are emerging as an alternative to static charging stations for electric vehicles. In order to ensure safe and reliable operation of future electric road deployments more knowledge and understanding is needed as to how electric transients occur and affect the electric road system and corresponding charging vehicle. This pa
The development of new industries in peripheral regions has gained renewed attention recently. Yet, the processes through which peripheral regions can mobilize external resources and capabilities, and turn them into locally sticky resources for structural change and longer-term economic prosperity, have not been sufficiently conceptualized. This article proposes anchoring-based regional system bui
Animal offerings made at various sacred sites were an integral part of the ethnic religion of the indigenous Sámi people of northern parts of present-day Norway, Sweden, Finland, and Russia from ca. 800 AD onwards. The offering tradition was interwoven with subsistence patterns and human-animal relationships, as in the Sámi worldview offerings were a means to communicate with gods and guardian spi
