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Importance: Persistent disparities in mortality across countries suggest uneven improvements in living standards and access to life-extending health technologies, as well as context-specific obstacles. Studies have analyzed cross-country inequality in mortality but have not widely contextualized those disparities in terms of developmental progress relative to a frontier representing a level of mor
BACKGROUND: The malaria parasite Plasmodium falciparum holds an extensive genetic polymorphism. In this pooled analysis, we investigate how the multiplicity in asymptomatic P. falciparum infections-that is, the number of coinfecting clones-affects the subsequent risk of clinical malaria in populations living under different levels of transmission.METHODS: A systematic search of the literature was
Recent studies have challenged earlier narratives of Africa as historically stagnant and impoverished, instead revealing patterns of booms and busts. While this has advanced understanding of long-term growth, significant gaps remain in our knowledge of historical poverty, especially among self-employed rural populations. This chapter uses published social tables to examine rural poverty in six Afr
The thermal regime is a key indicator of permafrost evolution and thaw trajectories in response to climate change but remains poorly represented in global models. In this study, we applied the Moving-Grid Permafrost Model (MGPM), an efficient numerical model, to simulate the permafrost thermal regime in West Kunlun (WKL), a 55 669 km2 region on the remote northwestern Qinghai-Tibet Plateau charact
Learning objectives: Describe the 3 stages of exploration and the 8 phases in the learning processCompare and contrast process-based and task-based assessmentEvaluate applicability of the presented knowledge in your professional practice Session description: Activity-based focus for practice in a power mobility device suggests integration of learning device-use in other activities aligning with th
Dr Lisbeth NilssonLearning objectives:1. Describe at least three essential aspects of the facilitating approach.2. Explain why these aspects can facilitate optimal outcomes of intervention.3. Evaluate usefulness of the universal facilitating approach in your own practice.Session description:The process of learning joystick-use and training strategies for each phase in the process were identified i
Transfecting clonal beta cells with large DNA plasmids holds significant promise for diabetes research. Existing transfection techniques like lipofection, viral transduction, and bulk electroporation often face limitations such as low efficiency and cytotoxicity. Nanoelectroporation, which utilizes nanopores or nanostraws and the application of mild electrical pulses, offers a gentle and safe alte
Rationally designing and fabricating high-performance core–shell nanostructures for catalytic organic synthesis is significant yet challenging. Here, we report a solvothermal/calcination strategy to prepare novel core–shell iron–aluminum oxide (FeAlOx) nanosphere-based nanoreactors incorporating active heterometals (AHM = Pd, Cu, or Mn). Leveraging the synergistic benefits of their unique core–she
Dr Lisbeth NilssonLearning objectives:1. Discover how and why technology can enable non-mobile infants and children in developing tool-use and participation with the world.2. Explain how and why experiences of self-produced movement in a powered device can impact on very young infants’ overall development3. Motivate provision of opportunities to explore and experience powered mobility to very youn
This thesis presents four interconnected studies showing methods for characterizing and separating cells based on their acoustic properties, with particular focus on isolating rare cells from blood samples.The first study introduces a technique for single-cell density measurements using microcapillary-adapted density gradient centrifugation. Using fluorescent markers to visualize the density gradi
In this issue of Cell Stem Cell, Márquez-Valadez, Gallardo-Caballero, and Llorens-Martín1 report that adult hippocampal neurogenesis (AHN) is differentially disrupted in neuropsychiatric disorders. Their findings highlight the role of the neurogenic niche and lifestyle, supporting the view of human AHN as a dynamic process sensitive to biology and behavior.
Responsible for roughly 40 % of global greenhouse gas emissions, energy usefor heating and cooling in the built environment constitutes a significant portionof annual total carbon emissions. The effort to decarbonise the heating andcooling sector necessitates efficient production, distribution and end use ofenergy. In this context, district heating and cooling is considered one of thecost-efficien
Background: People with hemophilia (PwH) or von Willebrand disease (VWD) are at risk of joint bleeding, which can lead to hemophilic arthropathy. Point-of-care musculoskeletal ultrasound (POC-MSKUS) is increasingly used to detect joint bleeds, but a comprehensive compilation of available independent scanning protocols and their respective measurement properties is missing. Objectives: This study a
In recent decades, with the advancement of technologies facilitating reproduction, parents have been able to make decisions regarding their childrens’ reproductive potential: to preserve their fertility when threatened by genetic conditions or medical treatment; to use their gametes or embryos to make grandchildren; or even to collect their gametes posthumously and then use them to make grandchild
Using structural properties of groups of small order, we establish the non-existence of varieties isogenous to a higher product of dimension n greater than 3 with fixed topological Euler number (-2)n and trivial first Betti number.
This paper examines the causal effect of public discourse in one or both sides of the market on overall market socially responsible behavior. In a laboratory setting, we vary whether firms and/or consumers participate in a public discussion before trading begins. When both sides take part, the share of socially responsible trades increases slightly; however, when only one side participates, market
Sexual conflict frequently gives rise to adaptations that increase male reproductive success at the expense of harming females (“male harm”) and decreasing population growth. Studying the ecology of male harm is paramount to understand how sexual conflict unfolds in nature, and its consequences for populations viability. Here, we used seed beetles (Callosobruchus maculatus), a species where males
Many studies that use an automated sorption balance to determine a water vapor sorption isotherm for wood collect data until the moisture content change is less than or equal to 0.002% min−1 (20 µg g−1 min−1). This stop criterion has been claimed to give errors in equilibrium moisture content (EMC) predictions of less than 0.001 g g−1 but over the past 10 years, studies have shown that the actual
