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The existence of an osteotropic hormone (referred to as gastrocalcin) in the ECL cells of the gastric mucosa has been suggested. Both gastrin and an extract of the oxyntic mucosa lower blood Ca2+ and stimulate Ca2+ uptake into bone. The ECL cells are known to operate under gastrin control and, conceivably, gastrin lowers blood Ca2+ indirectly by releasing the hypothetical ECL cell hormone. We have
