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To determine if an inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) can counteract the changes in urodynamic parameters and bladder afferent activities induced by intravesical prostaglandin E2 (PGE2 )-instillation, we studied effects of URB937, a peripherally-restricted FAAH inhibitor, on single-unit afferent activity (SAA) during PGE2 -induced bladder overactiv

INTRODUCTION: Elevated levels of markers for thrombin activation are associated with plaque echogenicity and degree of stenosis in patients with carotid artery stenosis. The Activated Protein C-Protein C Inhibitor (APC-PCI) complex reflects activation of the Protein C system and is a measure of thrombin generation. The aim of the present study was to examine APC-PCI complex in patients undergoing

meso-Tetra(hydroxyphenyl)chlorin (mTHPC) is an attractive second-generation dihydroporphyrin photosensitiser for use in photodynamic therapy. In this study, 1.3mgkg(-1) body weight mTHPC was administered intravenously, and laser-induced fluorescence was used to characterise and compare its localisation and retention in different rat tissues, including an induced experimental adenocarcinoma, 24 h a

The Bone and Joint Decade 2000-2010 started as a Swedish initiative in 1996 leading to the UN declaration 1999 followed by the WHO launch 2000. A ten year multidisciplinary and global endeavor moving musculoskeletal conditions onto the research and health agenda is now recognized. Some lessons learned during the journey are presented.

To assess the long-term effects of focal/grid laser treatment on the central visual field in subjects with clinically significant diabetic macular oedema (CSMO).

Patients with hip and knee osteoarthritis (OA) have high bone mineral density (BMD) and high BMI. If the same accounts for patients with foot or ankle OA is unknown.

The aim of the current study was to evaluate the effect of pelvic floor muscle training in men with poststroke lower urinary tract symptoms. Thirty-one poststroke men, median age 68 years, were included in this single-blinded randomized controlled trial. Thirty participants, 15 in each group, completed the study. The intervention consisted of 3 months (12 weekly sessions) of pelvic floor muscle tr

Acute pancreatitis (AP) is a common disease that has a mild to moderate course in most cases. During the last decade, a change in diagnostic facilities as well as improved intensive care have influenced both morbidity and mortality in AP. Still, however, a number of controversies and unresolved questions remain regarding AP. These include prognostic factors and how these may be used to improve out

Aim The aim of this study is to illuminate primary health care (PHC) nurses' experiences of physical activity referrals (PARs).

Measurements have been performed at eight laboratories on Raman-shifted radiation from frequency-quadrupled Nd:YAG and KrF lasers. Each of these sources is a possible candidate for making differential-absorption lidar measurements of ozone in the free troposphere. The spectral purity, efficiency and divergence of the different sources are compared and explained using a simplified model of the Rama

Activation of the platelet-derived growth factor (PDGF) beta-receptor leads to cell growth and chemotaxis. The PDGF alpha-receptor also mediates a mitogenic signal, but fails to induce cell migration in certain cell types. To examine this difference in signal transduction, a series of point-mutated PDGF alpha-receptors were analyzed. Porcine aortic endothelial cells expressing mutant PDGF alpha-re

We apply the Linked Dipole Chain model to hadronic collisions using a modified version of the LDCMC Monte Carlo program. In particular we investigate the effects of multiple scatterings, which in this framework are reformulated in terms of the production of multiple chains of dipoles. We find, among other things, that this way of describing multiple scatterings is less sensitive to the treatment o

The directional stability of an originally straight crack under symmetric remote loading is studied after introduction of an infinitesimal disturbance at one or both tips of the crack. The crack is assumed to grow slowly under vanishing mode II stress intensity factor. Directional stability is defined to prevail if the angle formed by the straight line between the crack tips and the original crack