Effect of DNAJB6 on α-synuclein amyloid fibril aggregation and dis-aggregation
Chaperoner – kroppens egna försvarssystem mot neurodegenerativa sjukdomar Parkinsons sjukdom och Alzheimers sjukdom är exempel på neurodegenerativa sjukdomar vars orsak attribueras till aggregeringen av amyloida proteiner. Chaperoner som DNAJB6 har visat sig vara effektiva i att förhindra denna aggregering, och i detta arbete har deras termodynamiska beskrivning undersökts. Proteiner är kroppens bAmyloid proteins are a group of proteins with the ability to form large fibrillar aggregates, identifiable by their cross-β core structure. These aggregates are linked to several different neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease and due to the growing rate of people diagnosed, there is a need to combat these diseases. Aggregation of amyloid proteins is caused