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Biografi: Ernest Rutherford, baron Rutherford of Nelson Mannen som formulerade atomkärnmodellen hade ingen vanlig barndom. Ernest Rutherford kom från en stor familj. Han var ett av tolv barn till James och Martha Rutherford, och under uppväxtåren flyttade familjen ofta på grund av faderns ar- bete. Det är möjligt att den flexibilitet som han behövde under barndomen för att kunna anpassa sig till d

https://www.nrcf.lu.se/sites/nrcf.lu.se/files/2025-11/Biografi_Ernest_Rutherford__baron_Rutherford_of_Nelson.pdf - 2026-07-23

Objective To assess the efficacy of paquinimod, a new immunomodulatory small molecule, in a murine lupus model, and to evaluate its pharmacokinetics and tolerability in systemic lupus erythematosus (SLE) patients at doses predicted to be efficacious and safe and determine the maximum tolerated dose. Methods The efficacy of paquinimod was studied in lupus-prone MRL-lpr/lpr mice and compared with th

Background: Emerging data propose biomarker alteration due to clonal selection between the primary invasive breast cancer and corresponding metastases. In addition, impact on survival has been demonstrated. The present study investigates the relationship between the oestrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) between primary ductal carcin

Purpose Cigarette smoking is the major pathogenic factor for lung cancer. The precise mechanisms of tobacco-related carcinogenesis, and its effect on the genomic and transcriptional landscape in lung cancer are not fully understood. Experimental Design 1398 (277 never-smokers, 1121 smokers) genomic and 1449 (370 never-smokers, 1079 smokers) transcriptional profiles were assembled from public lung

Background. The long-term effect of sustained virologic response (SVR) to antiviral therapy on the risk of developing hepatocellular carcinoma (HCC), liver complications, liver-related death, and overall death in hepatitis C virus (HCV)-infected patients with liver cirrhosis is not fully known. Methods. These risks were evaluated during long-term follow-up in 351 patients with HCV-related cirrhosi

Dug trenches in sediment-cored drumlins on the Småland peneplain, southern Sweden, occurring intermixed with rock-cored drumlins, revealed sedimentary successions and facies suggesting that the core sediments were primarily deposited proglacially, both in glaciolacustrine settings as delta-front and more distal deeper-water sediments, and as glaciofluvial braidplain sediments. From the relationshi

Background In mild asthma exercise-induced bronchoconstriction (EIB) is usually treated with inhaled short-acting beta(2) agonists (SABAs) on demand. Objective The hypothesis was that a combination of budesonide and formoterol on demand diminishes EIB equally to regular inhalation of budesonide and is more effective than terbutaline inhaled on demand. Methods Sixty-six patients with asthma (>12 ye

Qualitative measurements of both OH and polycyclic aromatic hydrocarbons (PAH) as well as quantitative data of soot volume fraction f(v) have been obtained in vaporized liquid fuels, with the main goal of providing experimental data for combustion models and numerical mechanism validation. Measurements were carried out in a laminar coflow burner which was designed, built and integrated with an eva

BACKGROUND AND OBJECTIVES: – The prognosis for functional independence after aneurysmal subarachnoid hemorrhage (aSAH) relies largely on patients' initial clinical status, age, and extent of the bleeding. However, some patients have poor outcome despite initially being in good clinical condition. The aim of this study was to analyze factors related to unfavorable outcome in patients with good clin

Forest fire is known as an important natural hazard in many countries which causes financial damages and human losses; thus, it is necessary to investigate different aspects of this phenomenon. In this study, performance of four models of linear and quadratic discriminant analysis (LDA and QDA), frequency ratio (FR), and weights-of-evidence (WofE) was investigated to model forest fire susceptibili

Background: Guidelines recommend systemic thrombolysis (ST) as first-line reperfusion therapy for highrisk pulmonary embolism (PE), however, clinical concerns regarding bleeding risk frequently limit its use in clinical practice. Catheter-directed therapy (CDT) should be considered when ST is contraindicated or has failed but is increasingly used outside these recommendations despite limited guide

The steel industry emits 2,400–2,713 Mt CO2 and 12 Mt of fugitive methane globally each year, yet progress towards decarbonization has been limited. In this Review, we examine the potential, feasibility and barriers to decarbonization of the steel sector. The blast furnace–basic oxygen furnace (BF–BOF) accounts for ~72% of global steel production and has the highest carbon emission intensity of ex

BACKGROUND: GP recruitment and retention difficulties challenge the traditional general practice model. Task-shifting and relieving GPs from financial risk have been suggested to make primary care more attractive. In Sweden's multiprofessional team-based primary care system, GPs usually work as salaried employees and there is extensive task-shifting. Salaried employment facilitates mobility, poten

Background: The objective of this systematic review is to identify prognostic factors among women and their offspring affected by gestational diabetes mellitus (GDM), focusing on endpoints of cardiovascular disease (CVD) and type 2 diabetes (T2D) for women, and cardiometabolic profile for offspring. Methods: This review included studies published in English language from January 1st, 1990, through

Purpose: We aimed to investigate the incidence and clinical features of Streptococcus dysgalactiae peripartum infections (SDPI), and to investigate the distribution of emm-types in relation to disease severity and the genetic relatedness of isolates from hospital clusters. Materials and methods: Patients with growth of S. dysgalactiae in a genital or wound culture, collected between January 2014 a

Objectives (1) To assess the risk of haematological malignancies in individuals with systemic sclerosis (SSc) compared with individuals without SSc; (2) to explore how the risk varies across groups stratified by sex and age; and (3) to determine when these malignancies present in relation to SSc diagnosis in a population-based setting. Methods We performed a nationwide cohort study using high-qual

Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes1,2 and molecular mechanisms that are often specific to cell type3,4. Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases

Suröl är en dryck som ökat i populäritet, speciellt bland folk med stort intresse för hantverksöl och mikrobryggerier. Allt fler bryggerier vågar nu att gå utanför sin trygghetszon med att använda jäst av typen Saccharomyces cerevisiae och istället börjar experimentera med bakterier och jäst som tidigare ansetts vara produktförstörande, till exempel olika mjölksyrabakterier och vildjäst. Genom forSour beer is rapidly gaining popularity among people that have an interest in craft beer and the microbrewing scene. This leads to breweries starting to venture outside their comfort zones regarding the more traditional brewing yeast Saccharomyces cerevisiae and instead have started experimenting with different kinds of bacteria and yeast that in a normal process is regarded as spoilage bacteria,