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BACKGROUND: Chronic obstructive pulmonary disease (COPD) has many known dysregulated inflammatory proteins. A disintegrin and metalloproteinase 17 (ADAM17) is a protease that sheds several proteins involved in COPD pathogenesis. The aim was to investigate ADAM17, its phosphorylated form (pADAM17) and its substrates in bronchoalveolar lavage (BAL) and blood from COPD and control subjects. METHODS:
Bakgrund: Ett mått på följsamhet till paleolitisk kost som inte baseras på populationsrelativa intag av livsmedelsgrupper har hittills saknats. Syftet med denna avhandling var att utvärdera användbarheten av Paleolithic Diet Fraction (PDF), ett nytt mått på följsamhet till paleolitisk kost, beräknat som andelen av det totala intaget av livsmedelsgrupper som utgörs av paleolitiska livsmedelsgrupperAbstract: Background: A measure of adherence to the Paleolithic diet not based on population-relative food group intakes was lacking. The aim of this thesis was to evaluate the usefulness of the Paleolithic Diet Fraction (PDF), a novel measure of adherence to the Paleolithic diet, calculated as the fraction of total food group intake derived from Paleolithic food groups. Methods: PDF was calculate
Background and purpose: Neuroblastoma is the most common extracranial solid tumour in children. Radiotherapy is commonly part of the multimodal treatment for high-risk patients. The aim of this study is to analyse doses to organs at risk (OAR) in comparative proton and photon treatment plans for children treated for neuroblastoma and report side effects. Patient/material and methods: All children
Epilepsy is a prevalent neurological disorder characterized by spontaneous recurrent seizures (SRS). Epileptogenesis is a multifaceted pathophysiological process that transforms a normal brain into one prone to chronic seizures. Targeting epileptogenesis is a compelling line of epilepsy therapy. Thus, discovering new drugs that oppose, mitigate, or modify epileptogenesis is a significant challenge
Background: Studies in breast cancer patients have consistently shown that physical activity improves survival. We examined if change in physical activity from before to after a breast cancer diagnosis is associated with outpatient specialist care use and hospitalisations in women with type 2 diabetes mellitus (T2DM). Methods: This register-based cohort study included 2145 women with T2DM who self
Background: This study aimed to assess chlamydia diagnostics in different clinic types, including internet-based self-sampling (IBSS). Furthermore, we investigated the incidence of chlamydia-associated complications. Methods: Data on Chlamydia trachomatis (CT) testing were retrieved from six healthcare regions in the years 2016–2023 across different categories of testing facilities. National data
Introduction Autistic persons experience problems with movements and body awareness in everyday functionality, expressed in affected movement quality. Yet, there is a knowledge gap about the effects of interventions targeting these aspects in autistic persons. Objective To evaluate effects of Basic Body Awareness Therapy (BBAT) and treatment-as-usual (TAU), compared to TAU alone on movement qualit
Introduction: Early-life determinants of middle-age cardiovascular health are poorly understood. This study examines associations of BMI and physical fitness in male adolescents with cardiovascular health measured by the Life's Essential 8 score in middle age. Methods: A population-based cohort study linked BMI and physical fitness from the Swedish Military Conscription Register (men conscripted f
Background and purpose —The use of a tourniquet in knee replacement surgery is debated. Given the conflicting evidence, we aimed to compare the risk of revision after total knee replacements (TKR) with or without the use of tourniquet. Methods — In this register based observational study, we included the 5 most common cemented primary TKR models due to osteoarthritis reported to the Swedish Arthro
Aims To explore the prevalence and incidence of paediatric implantable cardioverter-defibrillator (ICD) patients in Sweden and identify risk factors associated with appropriate shocks and adverse events. Methods and results We performed a nationwide, retrospective cohort study of ICD use in paediatric patients (<19 years) between 1995 and 2017; 120 patients underwent ICD implantation at median age
Background: Bile leakage is a severe complication after cholecystectomy and is associated with an increased risk of morbidity and mortality. The aim of this study was to evaluate the incidence of bile leakage post-cholecystectomy and to identify potential risk factors and their association with changes in the incidence of bile leakage over time. Methods: Demographic and perioperative data of all p
INTRODUCTION: Intracranial haemorrhage (ICH) is the most serious complication in infants and children with severe congenital bleeding disorders causing substantial mortality and long-term neurological morbidity. The neonatal period carries the highest risk, particularly in severe haemophilia and rare factor deficiencies. We review the epidemiology, risk factors, prevention, recognition, management
PurposeTürkiye ranks among the highest in antibiotic consumption within OECD countries and faces growing challenges from multidrug-resistant uropathogens. Nationwide, resistance-guided treatment data remain scarce. The main objective of this work is to provide a comprehensive nationwide data on antibiotic resistance patterns among uropathogens to guide treatment options in urinary tract infections
OBJECTIVE: To assess structural changes at peripheral entheses and the association with spinal bone formation in patients with long-standing radiographic axial spondyloarthritis (r-axSpA) overall and stratified by sex. METHODS: Peripheral entheses were examined cross-sectionally using ultrasound (US) in patients fulfilling the modified New York criteria for ankylosing spondylitis (AS) and assessed
From the Wunderkammern of Renaissance Europe to the curated vaults of today’s natural history museums, millions of insect specimens have been preserved, capturing an irreplaceable chronicle of biodiversity, including lineages that are rare, highly specialized, or already extinct. Yet their fragility has historically constrained genomic inquiry. Here, we apply museomic methodology to a >40-year-old
Studying the full universe of nearly 390,000 French patents filed between 1791 and 1900, I show that the nineteenth-century gender patenting gap arose less at the patent office than through unequal access to practical knowledge, collaborators, and time across the life course. I identify 4,165 women inventors using gender-specific honorifics, classify patents with machine learning, reconstruct the
Background Severe exacerbations (SevEx), the typical endpoint when evaluating asthma therapies, may provide incomplete assessment, as it relies on patient perception of disease and physician action. CompEx, a composite outcome that includes SevEx and acute worsening events (AWEs) (evaluated from e-diary entries using deterioration in peak expiratory flow (PEF), reliever medication use and worsenin
BACKGROUND AND OBJECTIVES: – The prognosis for functional independence after aneurysmal subarachnoid hemorrhage (aSAH) relies largely on patients' initial clinical status, age, and extent of the bleeding. However, some patients have poor outcome despite initially being in good clinical condition. The aim of this study was to analyze factors related to unfavorable outcome in patients with good clin
