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Background Clinical classification of rare sequence changes identified in the breast cancer susceptibility genes BRCA1 and BRCA2 is essential for appropriate genetic counselling of individuals carrying these variants. We previously showed that variant BRCA1 c.5096G>A p.Arg1699Gln in the BRCA1 transcriptional transactivation domain demonstrated equivocal results from a series of functional assays,
Target-specific molecular imaging with radiolabeled antibodies has experienced a rapid growth over the past 20 years, and is now an essential tool to provide information on disease presence and extent. Despite all efforts to detect and control prostate cancer at an early stage, a number of men are still progressing to develop incurable metastatic disease. Because of this, development of new method
Understanding and being able to quantify sitting postures is a central asset in car safety evaluations. This is due to the fact that passengers can choose a range of different sitting positions. Studying and understanding how passengers choose to sit to obtain some comfort is important for increased safety in futures cars and is particularly challenging facing a heterogeneous population. Data is a
Den 1 oktober 2009 trädde en de nya Takeover-reglerna i kraft. Den största nyheten i de nya reglerna var den kraftigt minskade möjligheten att erbjuda röststarka aktier ett högre pris än röstsvaga aktier i ett offentligt uppköpserbjudande. Detta är en skärpning av den aktiemarknadsrättsliga likhetsprincipen och avsikten var att tillförsäkra minoritetsägare en större del av uppköpspremien. UppsatseThe 1 October 2009 new Takeover Rules entered into force. The most material change of the new rules was that they decreased the possibility to offer multiple voting shares a higher price than ordinary shares. This is a strengthening of the legal principle of equality as applied at the Nasdaq OMX Stockholm stock market. The intention was to ensure that minority shareholders got a greater share of t
Den allmänna rösträtten har genom historien varit något som människor be-hövt kämpa för. Idag kan man tycka att det ska vara en självklarhet att alla människor är berättigade lika och allmän rösträtt, men så har fallet långt ifrån alltid varit. Så sent som 1965 såg man till att alla svarta medborgare i USA tilläts utöva sin rätt att rösta. I Sverige, Storbritannien och USA finns det många likhetUniversal suffrage has throughout history been something people have had to fight for. Today, it may seem self-evident that all people are equally entitled to universal suffrage, but this has far from always been the case. As recently as 1965, measures were taken to ensure that all Black citizens in the United States were allowed to exercise their right to vote. In Sweden, Great Britain, and the
Isolating fragile and heterogeneous cell populations from complex tissues remains a core challenge in biomedical research. In the bone marrow (BM), bone marrow adipocytes (BMAds) are key regulators of hematopoiesis and metabolism, yet their large size, fragility, and lack of specific surface markers have hindered their isolation using conventional methods such as fluorescence-activated cell sortin
Subject motion and eddy-current distortions represent significant challenges in diffusion MRI, particularly for clinical protocols utilizing "half-sphere" sampling. While the current gold standard, FSL’s eddy, employs Gaussian Process (GP) predictions to correct these artifacts, its performance can degrade under specific acquisition constraints, most notably when sampling lacks antipodal
Guðrún Guðjónsdóttir Climate change is having a great impact on the fragile High Latitude environment where warming is occurring at a rate at least double the global average. It is urgent to understand the relationship between climate and vegetation cover, which is playing an important role, as a carbon sink, for biodiversity, and for protecting against natural hazards. Less studied but equally i
Värdering av obebyggd tomtmark för småhus kan ibland vara svårt då det saknas ett bra ortsprismaterial. Ännu svårare är att värdera tomtmark för småhus som är bebyggda med byggnader på ofri grund. Tomtmark med byggnader på ofri grund upplåtna med nyttjanderätter anses ha ett lägre värde än tomtmark som är obebyggd eller tomtmark som är bebyggd av fastighetens ägare. Det beror på att nyttjanderätteThe objective of this work is to examine the impact on value that a house on leasehold has on the underlying land in a partition ordinance. In order to build a foundation and create an understanding about houses on leasehold, partitiontools and different methods of valuation I undertook literature studies. The literature consisted of, among other things, preparatory work for FBL and the Court of A
Clusters are particles which consist of a finite number (2 − 10 ^6−7 ) of atoms/molecules. For the work presented in this thesis free clusters have been produced in order to study their properties, free of interfering substrates, using photoelectron spectroscopy at the MAX-lab synchrotron facility in Lund, Sweden. The clusters were produced using a magnetron-based sputtering source and are conside
In nuclear medicine, radiopharmaceuticals can be administered for both diagnostic and therapeutic purposes. In recent years, there has been an increasing interest in theragnostics, a strategy that combines both diagnosis and therapy. This can be achieved by using similar radiopharmaceuticals for imaging and radionuclide therapy, which enables highly personalised disease management. One theragnosti
OBJECTIVE The long-term association between dietary protein and type 2 diabetes incidence is uncertain. We aimed to investigate the association between total, animal, and plant protein intake and the incidence of type 2 diabetes. RESEARCH DESIGN AND METHODS The prospective European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study consists of 12,403 incident typ
OBJECTIVES: Analyses performed by the Sarcopenia Definitions and Outcomes Consortium (SDOC) identified cut-points in several metrics of grip strength for consideration in a definition of sarcopenia. We describe the associations between the SDOC-identified metrics of low grip strength (absolute or standardized to body size/composition); low dual-energy x-ray absorptiometry (DXA) lean mass as previo
Research suggests that polyphenols, such as anthocyanins, that are found in considerable amounts in many types of berries, contributes with a positive effect on human cognition. However, clinical trials are warranted to support these findings. Preparation for such a trial includes developing a berry-rich study product and a corresponding reference beverage. Phenolic compounds are highly unstable a
The overall aim of this thesis was to describe changes in the prevalence and severity of periodontal diseases and to identify risk factors for severe periodontal disease in adults living in Jönköping County, Sweden, by analysing the cross-sectional, epidemiological studies that had been carried out in the city of Jönköping in 1973, 1983, and 1993. Individuals were randomly selected from the follow
