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BACKGROUND: An increasing number of monogenic conditions underlying stroke are being identified. We explored the possibilities of increasing the diagnostic yield of monogenic stroke in a population under 56 years of age. METHODS: Fifty probands ≤55 years at their first stroke episode were characterized clinically and investigated by whole genome sequencing. Probands had one or more of: (1) one or
The Gaia-ESO Survey is an European Southern Observatory (ESO) public spectroscopic survey that targeted 105 stars in the Milky Way covering the major populations of the disk, bulge and halo. The observations were made using FLAMES on the VLT obtaining both UVES high (R ~ 47 000) and GIRAFFE medium (R ~ 20 000) resolution spectra. The analysis of the Gaia-ESO spectra was the work of multiple analys
PURPOSE: Clinical relapse is the major threat for patients with myelodysplastic syndrome (MDS) undergoing hematopoietic stem-cell transplantation (HSCT). Early detection of measurable residual disease (MRD) would enable preemptive treatment and potentially reduced relapse risk.METHODSPatients with MDS planned for HSCT were enrolled in a prospective, observational study evaluating the association b
Background Exertional breathlessness is a key symptom in cardiorespiratory disease and can be quantified using incremental exercise testing, but its prognostic significance is unknown. We evaluated the ability of abnormally high breathlessness intensity during incremental cycle exercise testing to predict all-cause, respiratory, and cardiac mortality. Study design and methods Longitudinal cohort s
Fog makes a significant contribution to the hydrology of a wide range of important terrestrial ecosystems. The amount and frequency of fog immersion are affected by rapid ongoing anthropogenic changes but the impacts of these changes remain relatively poorly understood compared with changes in rainfall. Here, we present the design and performance of a novel experiment to actively manipulate low ly
Introduction: No national recommendation for antibiotic prophylaxis for planned caesarean section in Sweden exists. Swedish delivery units have chosen different strategies. Some units routinely administer antibiotic prophylaxis to all women for whom a caesarean section is planned, while other units give prophylactic antibiotics to risk groups only. We took advantage of this “natural experiment” to
High-Arctic environments are facing an elevated pace of warming and increasing human activities, making them more susceptible to the introduction and spread of alien species. We investigated the role of human disturbance in facilitating the spread of a native plant (Papaver dahlianum) in a high-Arctic natural environment close to Isfjord Radio station and along adjacent hiking trails at Kapp Linné
Background: Long-term data on safety and efficacy of instantaneous wave-free ratio (IFR) vs fractional flow reserve (FFR) in guiding percutaneous coronary intervention (PCI) is lacking. Objectives: This study sought to evaluate the 5-year clinical outcomes of IFR- vs FFR-guided PCI in a real-world setting. Methods: We assessed the 5-year outcomes of all patients undergoing IFR or FFR assessment be
Soluble urokinase plasminogen activator receptor (suPAR) is an inflammatory marker that has been shown to predict poorer outcomes in cardiovascular disease and after cardiac surgery. The relationship between suPAR concentrations and postoperative complications after valvular surgery, however, remains unclear. This study aims to evaluate the predictive value of suPAR concentrations for infection, a
Övergången till mer hållbara livsmedelssystem och växtbaserade proteinkällor har blivit allt viktigare för att minska livsmedelssystemets klimatpåverkan. Rapsfrökaka är en restprodukt från oljeextraktion med potential att användas som råvara för proteinutvinning och vidare tillämpning i växtbaserade livsmedel tack vare dess balanserade komposition av aminosyror. På grund av bitter smak och högt inThe transition to more sustainable food systems and plant-based protein sources has become increasingly important in reducing the climate impact of the food system. Rapeseed press cake is a by-product of oil extraction that has the potential to be used as a raw material for protein extraction and further use in plant-based foods, thanks to its balanced amino acid profile. Due to its bitter taste a
Patient-specific fluid-structure interaction (FSI) simulations can improve the understanding of mitral valve dysfunction and support preoperative planning. However, existing contracting left ventricular (LV) FSI models are often computationally demanding which limits their clinical applicability. This thesis addresses these limitations by developing a patient-specific contracting LV model within a
ObjectiveTo compare the early and midterm outcomes of left subclavian artery revascularization during thoracic endovascular aortic repair (TEVAR) following carotid subclavian bypass/transposition (CSB) vs. fenestrated repair when landing in zone 1/2. Propensity score matching (PSM) was applied to adjust for baseline differences.MethodsDEbranching versus FENestrated Repair for Left SubClavian Arter
This study examines landslide occurrence and post‑landslide recovery dynamics in Nyungwe Forest Reserve, Rwanda, using a combination of multi‑temporal landslide mapping, environmental and geomorphological predictor analysis, and an assessment of the Tropical Moist Forest (TMF) product. A landslide inventory covering the period from 2000 to 2024 was produced using high‑resolution optical imagery. T
Objective This study attempted to quantify the bias expected due to partly interval-censored (IC) outcomes in the estimated association between hydroxychloroquine (HCQ) taper/cessation and time to disease flare among individuals with systemic lupus erythematosus (SLE). Methods Using data-driven simulations, we estimated bias expected due to IC using real-world data from the Systemic Lupus Internat
Fractures pose a significant burden on society, making prevention strategies important. One approach is to increase physical activity (PA), which may enhance bone mass and muscle strength, thereby lowering fracture risk. A total of 3476 children who began 1st grade (mean age 7 years) between 1998 and 2012 in four Swedish schools were included. The intervention group was 1328 children from one scho
OBJECTIVES: Patients with chronic obstructive pulmonary disease (COPD) who also have acute coronary syndromes are a high-risk population with a high mortality rate. Little is known about these patients following coronary artery bypass grafting (CABG). METHODS: Patients presenting with acute coronary syndromes between 2006 and 2014 with an angiogram showing 3-vessel disease or left main coronary ar
A comparison was made between two plant peroxidases, cationic horseradish peroxidase (HRP) and anionic tobacco peroxidase (TOP), combined with a highly cationic osmium polymer [Os(4,4'-dimethyl-2,2'-bipyridine)2poly(N-vinylimidazole)10Cl]+2/+ ([Os(dmp)PVI]+/2+) to develop highly sensitive, stable and selective hydrogen peroxide biosensors. The two different plant peroxidases were individually immo
Osteoporosis is a common disease with a strong genetic component, characterized by reduced bone mineral density and increased fracture risk. Although the genetic basis of osteoporosis is incompletely understood, previous studies have identified a polymorphism affecting an Sp1 binding site in the COLIA1 gene that predicts bone mineral density and osteoporotic fractures in several populations. Here
