Filtyp
Background: Physical activity (PA) in childhood is critical for establishing a healthy lifestyle across the lifespan, particularly to treat and prevent obesity. This study aimed to explore PA and sedentary behaviour (SED) in 6–12-year-old children with obesity and their parents, and possible associations in these behaviours between children and parents. Methods: Children referred to outpatient pae
Objective: Drug-coated balloons (DCB) might improve the results of below the knee (BTK) angioplasty, but sufficient randomized data comparing DCB and conventional angioplasty in treating patients with chronic limb threatening ischemia (CLTI) are lacking. This study aimed to perform a randomized comparison between a paclitaxel-coated angioplasty balloon catheter and a conventional balloon angioplas
Background: Acute kidney injury (AKI) is a common complication of coronary artery bypass surgery (CABG) and is associated with worse outcomes. It remains unclear whether AKIs impact on prognosis can be attributed to other concurrent major complications. Methods: This retrospective cohort study included consecutive patients undergoing isolated CABG at a single nationwide center from 2001 to 2020. P
Background: Large bone defects are challenging to manage clinically and usually require treatment with bone graft or bone graft substitute. This study evaluated the effect of romosozumab, a sclerostin antibody, in combination with demineralized bone matrix (DBM) on bone regeneration in a critical-size ulnar defect model in nonhuman primates. Methods: In cynomolgus monkeys (N = 22, male, 10–12 year
BACKGROUND: The implementation of COVID-19 vaccination among older persons at nursing homes has lowered the infection-associated mortality considerably, but emerging virus variants and decline in vaccine-induced immunity over time necessitate examination of future booster dosing strategies. The overall aim of this study was to assess vaccine protection against COVID-19 mortality in relation to tim
Background: There has been an increasing number of single-centre studies describing the long-term outcomes of patients with Hirschsprung disease. This study aimed to systematically review the literature on long-term bowel, urological, and sexual functional outcomes, fertility and quality of life in adults with Hirschsprung disease. Methods: A PROSPERO-registered systematic review of the English li
Background Nurses constitute a central profession in the cardiac rehabilitation (CR) team delivering comprehensive CR to individuals with cardiovascular disease. We aimed to identify specific components reflecting the nurses' role in the CR team associated with attainment of risk factor targets post myocardial infarction. Methods Center-level data (n = 78) was used from the Perfect-CR study, in wh
Background Dietary diversity may affect type 2 diabetes (T2D) but no studies have examined protein diversity by source. We examined five diversity scores and the 10-year risk of T2D and effect modification. Methods A prospective study of 10 363 incident T2D cases and a representative sub-cohort of 13 937 individuals sampled from a cohort of 340 234 participants in eight European countries (1993-20
Background: Medial plica is a structure with limited understanding of its pathology, but it may be related to the development of medial knee osteoarthritis (OA). We examined the association between medial plica and medial meniscus extrusion (MME), progression of MME, and the risk of early-stage knee OA development in middle-aged persons. Methods: A total of 340 subjects with tibiofemoral Kellgren–
Background and purpose: Hormone-receptor-positive/HER2-negative (HR+/HER2-) early-stage breast cancers (EBCs) display heterogenous responses to neoadjuvant chemotherapy (NACT) warranting biomarkers to tailor optimal treatment for individual patients. Patients/material and methods: Women with HR+/HER2-EBC (N = 178) included in the Swedish Sweden Cancerome Analysis Network-Breast (SCAN-B) population
BACKGROUND: We hypothesized that the main barriers to integrating exercise in routine care of patients with chronic kidney disease (CKD) were structural within European healthcare systems rather than due to resistance among healthcare professionals or patients.MATERIALS AND METHODS: This descriptive cross-sectional study used anonymized questionnaires to investigate nurses' and physicians' attitud
Background Previous studies of minimally invasive liver surgery described results and experiences in high-volume centres and early adopters, but data on national levels are lacking. This study evaluated the implementation and outcomes of minimally invasive liver surgery in Sweden over a 15-year period, with a focus on colorectal liver metastases. Methods Data from patients undergoing liver surgery
Background. Climate change is the greatest threat to human health in the 21st century and healthcare contributes to approximately 5% of global greenhouse gas emissions. Intensive and perioperative care are particularly resource intensive. This thesis aimed to assess the climate and environmental impacts of perioperative and intensive care (Papers I–III) and to explore how environmental outcomes an
Background The dura mater has a permeable vasculature similar to that of peripheral organs, and is separated from the brain, which is enclosed within the arachnoid barrier. Fluid and solute transport across the arachnoid barrier between the subarachnoid space (SAS) and dura is crucial for brain waste clearance and immune surveillance, but few neuroimaging approaches can capture this dynamic proces
Background and purpose: Stereotactic radiosurgery (SRS) requires high positional accuracy to safely deliver large doses. This study evaluated an integrated surface- and image-guided radiotherapy (SGRT-IGRT) system by analysing (1) the agreement between thermo-optical and stereoscopic X-ray positioning, and (2) the impact of intra-fractional workflows on treatment accuracy and time. Materials and m
This thesis is built upon four research projects, in which we investigated different aspects of increasing the diagnostic yield of blood cultures. Blood culture sampling using a single venipuncture (single-sampling strategy, SSS) is non-inferior to sampling from two separate venipunctures when sensitivity is considered. The effect of SSS on blood culture contamination rate is less known. In Study
Premise: Flower color, a key trait influencing plant–pollinator interactions, may be influenced by abiotic factors such as soil. We investigated association between pollinators, soil characteristics, and flower color variations in Digitalis purpurea across native populations in Sweden and introduced populations in Bolivia. Methods: We measured floral traits, reflectance of petals and nectar-guide
Taurine, an amino sulfonic acid abundant in seafood and meat, has been proposed to have a potential role in the prevention of metabolic dysfunction-associated steatotic liver disease (MASLD) due to its antioxidant and anti-inflammatory properties. However, the association between dietary taurine intake and MASLD remains unclear in human populations. Also, data on dietary taurine intake among adult
Objective This study aims to investigate whether oral fluoroquinolone use is associated with an increased risk of aortic and mitral valve regurgitation. Design A nationwide cohort study based on linked healthcare register data encompassing patient characteristics, prescription data and cases of aortic and mitral valve regurgitation. Setting Sweden, 2006–2018. Participants Study participants were a
