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Introduction Severe osteogenesis imperfecta (OI) is a debilitating disease with no cure or sufficiently effective treatment. Mesenchymal stem cells (MSCs) have good safety profile, show promising effects and can form bone. The Boost Brittle Bones Before Birth (BOOSTB4) trial evaluates administration of allogeneic expanded human first trimester fetal liver MSCs (BOOST cells) for OI type 3 or severe
BACKGROUND AND OBJECTIVE: Infection after transrectal prostate biopsy (TPBx) is a well-known risk. A comprehensive investigation of risk factors may identify measures for safe TPBx as an alternative to a change in biopsy route. The aim of this study was to identify risk factors for infection after TPBx.METHODS: We included all outpatient TPBx cases in Region Kronoberg, Sweden, from January 2010 to
Background: The quality of the total mesorectal excision specimen in rectal cancer surgery is assessed with a three-tier grade (mesorectal, intramesorectal and muscularis propria). This study aimed to analyse the prognostic impact of the total mesorectal excision grade on survival, and to identify risk factors for intramesorectal and muscularis propria resection in a population-based setting. Meth
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Under de senaste åren har efterfrågan på textilier ökat och andelen textilavfall som återvinns är i dagsläget liten vilket har lett till en ökad miljöpåverkan. Det finns därmed ett behov av nya återvinningsprocesser för textilier, där en möjlighet är att de-polymerisera cellulosa-baserade textilier till glukos genom en alkalisk förbehandling, följt av enzymatisk hydrolys. Att integrera textilåtervOver the past years there has been an increased environmental impact due to an increased textile demand. Only a small fraction of waste textiles is recycled today which indicates a requirement for new textile-recycling processes, where one possibility would be to depolymerize cellulose-based textiles into glucose, with an alkaline pretreatment followed by enzymatic hydrolysis. Due to a high energy
Segregation är ett vanligt fenomen som uppstår över hela världen. De negativa konsekvenserna av boendesegregation har visat sig vara många för de som bor i mindre välbärgade stadsdelar. Bland konsekvenserna finns bland annat hälsorelaterade motgångar, men även sämre förutsättningar under skolgången och i det framtida arbetslivet har konstaterats. Sydafrika lämpar sig väl för att studera segregatioSegregation is a common phenomenon arising worldwide. Residential segregation has been shown to have several negative consequences for people living in less wealthy neighbourhoods, such as health-related setbacks and being less likely to cope with school. South Africa is an especially well-suited country to study segregation and methods to counteract it to achieve better integration and more harmo
Proteins and peptides are widely used for the prevention, management, and cure of various illnesses. This vast therapeutic potential represents a significant portion of the pharmaceutical industry in the form of vaccines, antibodies, enzymes, and other protein-based therapeutics. During the drug development process, these proteins/peptides are affected by various environmental factors such as temp
One problem with the Swedish railways is the low reliability and punctuality. A distinction can be made between major and minor disorders, where minor disorders have a greater impact on overall punctuality because of its large numbers. One way to describe the large disorders are with punctuality dips and punctuality depressions, which are short-term and long-term variations in punctuality. This st
Introduction: Calcium is an important ubiquitous second messenger regarding the maintenance of cellular homeostasis, and is therefore tightly regulated. Calcium induces cell death when internalised into cancer cells after permeabilization of the cell membrane by electroporation. It is established that radiation causes damage to the lipids and proteins of the cell membrane; and ionizing radiation a
Increasing demand for metals might lead to extraction of metals from materials, previously, thought of as waste. A letter by the Swedish Environmental Protection Agency and Geological Survey of Sweden from 2017 encouraged new and innovative waste treatments as well as recycling of waste produced in association with mining. The conventional treatment of acid mine wastewater creates large volumes of
The Swedish consumers consumed in 2014 13.1 kilo textilies, of this 8 kilogram was dicarded via household waste and used for energy production. European Union’s waste hierarchy avocates a higher rate of reuse and recycling for a more sustainable textile flow. The Swedish goverment is, therefor, working toward new laws and guidelines which can lead to an expanded responsibility for the municipaliti
Sammanfattning Detta arbete har delats in i två delar. Den första delen handlar om olika energilagringstekniker. Den andra delen handlar om att lagra egenproducerad elenergi i ett flerbostadshus. Syftet med första delen har varit att samla information om olika energilagringstekniker i en kunskapssammanställning genom att studera dess funktion, aktuella status och framtidsutsikter. Den andra delen Abstract This master thesis is divided into two parts. The first part deals with a general study of different energy storage systems. The second part deals with the possibility to store own-produced electricity from solar panels in a multifamily residential area. The purpose of the first part was to collect information about different energy storage systems in a general study, and examine their di
SiS särskilda ungdomshem är institutioner där barn och unga i behov av särskild tillsyn placeras, till största del sker detta med stöd av lagen (1990:52) med särskilda bestämmelser om vård av unga (LVU). Uppsatsen syftar till att utreda i vilken utsträckning rätten till hälsa enligt artikel 24 i Förenta nationernas konvention om barnets rättigheter (barnkonventionen), är uppfylld för flickor med SiS youth homes are institutions which provides compulsory care for young people with psychosocial problems, with legal support usually found in the act (SFS 1990:52) with special provisions on the care of young people (LVU). The purpose of the thesis is to examine whether the right to health as established in art. 24 of the UN Convention on the Rights of the Child, is respected for girls with men
Aktivt kol har identifierats som en av de mer effektiva metoderna när det kommer till att avlägsna organiska mikroföroreningar (OMF) från avloppsvatten. Aktivt kol är ett poröst material med stor ytarea som kan adsorbera andra ämnen. Det är inget som existerar naturligt utan behöver framställas. Framställningen kan ske från i princip vilket material som helst som har en hög kolhalt. En stor del avActivated carbon has been identified as one of the more effective methods of removing organic micropollutants (OMP) from wastewater. Activated carbon is a porous material with a large surface area that allows adsorption of other substances. The material does not exist naturally and therefore has to be produced. The production can be done from any carbon-rich material and today the precursor is mai
Rennet coagulation ability of milk is of utmost importance in cheese manufacturing industry since it is directly related to cheese quality and yield, then translated into economic benefit. This study examined the rennet coagulation ability and composition of milk from individual Swedish Red (SR) cows, the second most common dairy breed in Sweden. Additionally, the study explored how the presence o
The purpose of this research is to achieve a deeper insight of the emulsifying, suspending, and gelling properties of the meat proteins and see the possibility to use them to produce reduced-salt emulsion-type sausages. Sarcoplasmic and myofibrillar proteins were extracted from pork (longissimus dorsi, LD). Firstly, their aggregation behaviors in different salt concentrations – namely, 0.15 M, 0.4
Buildings from the so called Million programme has a high use of energy and in addition, there are many such houses. The need for them to be retrofitted is big. The City of Helsingborg has set a climate goal which states that the city in 2035 should be neutral in energy use which put a lot of pressure on the real estate owners in the city. All new buildings has to be energy efficient and older bui
