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Studies that have examined the association between alcohol consumption and gastric cancer (GC) risk have been inconsistent. We conducted an investigation of 29 genetic variants in alcohol metabolism loci (alcohol dehydrogenase, ADH1 gene cluster: ADH1A, ADH1B and ADH1C; ADH7 and aldehyde dehydrogenase, ALDH2), alcohol intake and GC risk. We analyzed data from a nested case-control study (364 cases
rs7629265 and AF Risk ObjectiveWe examined the association of rs7626962 (S1103Y) or rs7629265, a variant in high linkage disequilibrium with S1103Y (r(2) = 0.87 - 1), with sudden cardiac death (SCD) and atrial fibrillation (AF) among African Americans. BackgroundThe SCN5A missense variant S1103Y has been associated with SCD among African Americans in small case-control studies, but larger populati
MicroRNAs (miRNAs) are post-transcriptional gene regulators involved in a wide range of biological processes including tumorigenesis. Deregulation of miRNA pathways has been associated with cancer but the contribution of their genetic variability to this disorder is poorly known. We analyzed the genetic association of gastric cancer (GC) and its anatomical and histological subtypes, with 133 singl
Background: Childhood cancer predisposition (ChiCaP) syndromes are increasingly recognized as contributing factors to childhood cancer development. Yet, due to variable availability of germline testing, many children with ChiCaP might go undetected today. We report results from the nationwide and prospective ChiCaP study that investigated diagnostic yield and clinical impact of integrating germlin
A new encapsulation strategy for probiotics is highly needed to tackle the challenge of significant viability loss of bacteria during storage and passage through the gastrointestinal system. A new controlled delivery system for probiotics based on EC oleogels is proposed in this thesis. A relatively non-complicated in vitro lipolysis model was established to evaluate the relative conversion from t
Introduction Severe osteogenesis imperfecta (OI) is a debilitating disease with no cure or sufficiently effective treatment. Mesenchymal stem cells (MSCs) have good safety profile, show promising effects and can form bone. The Boost Brittle Bones Before Birth (BOOSTB4) trial evaluates administration of allogeneic expanded human first trimester fetal liver MSCs (BOOST cells) for OI type 3 or severe
BACKGROUND AND OBJECTIVE: Infection after transrectal prostate biopsy (TPBx) is a well-known risk. A comprehensive investigation of risk factors may identify measures for safe TPBx as an alternative to a change in biopsy route. The aim of this study was to identify risk factors for infection after TPBx.METHODS: We included all outpatient TPBx cases in Region Kronoberg, Sweden, from January 2010 to
Background: The quality of the total mesorectal excision specimen in rectal cancer surgery is assessed with a three-tier grade (mesorectal, intramesorectal and muscularis propria). This study aimed to analyse the prognostic impact of the total mesorectal excision grade on survival, and to identify risk factors for intramesorectal and muscularis propria resection in a population-based setting. Meth
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Under de senaste åren har efterfrågan på textilier ökat och andelen textilavfall som återvinns är i dagsläget liten vilket har lett till en ökad miljöpåverkan. Det finns därmed ett behov av nya återvinningsprocesser för textilier, där en möjlighet är att de-polymerisera cellulosa-baserade textilier till glukos genom en alkalisk förbehandling, följt av enzymatisk hydrolys. Att integrera textilåtervOver the past years there has been an increased environmental impact due to an increased textile demand. Only a small fraction of waste textiles is recycled today which indicates a requirement for new textile-recycling processes, where one possibility would be to depolymerize cellulose-based textiles into glucose, with an alkaline pretreatment followed by enzymatic hydrolysis. Due to a high energy
Segregation är ett vanligt fenomen som uppstår över hela världen. De negativa konsekvenserna av boendesegregation har visat sig vara många för de som bor i mindre välbärgade stadsdelar. Bland konsekvenserna finns bland annat hälsorelaterade motgångar, men även sämre förutsättningar under skolgången och i det framtida arbetslivet har konstaterats. Sydafrika lämpar sig väl för att studera segregatioSegregation is a common phenomenon arising worldwide. Residential segregation has been shown to have several negative consequences for people living in less wealthy neighbourhoods, such as health-related setbacks and being less likely to cope with school. South Africa is an especially well-suited country to study segregation and methods to counteract it to achieve better integration and more harmo
Proteins and peptides are widely used for the prevention, management, and cure of various illnesses. This vast therapeutic potential represents a significant portion of the pharmaceutical industry in the form of vaccines, antibodies, enzymes, and other protein-based therapeutics. During the drug development process, these proteins/peptides are affected by various environmental factors such as temp
One problem with the Swedish railways is the low reliability and punctuality. A distinction can be made between major and minor disorders, where minor disorders have a greater impact on overall punctuality because of its large numbers. One way to describe the large disorders are with punctuality dips and punctuality depressions, which are short-term and long-term variations in punctuality. This st
Introduction: Calcium is an important ubiquitous second messenger regarding the maintenance of cellular homeostasis, and is therefore tightly regulated. Calcium induces cell death when internalised into cancer cells after permeabilization of the cell membrane by electroporation. It is established that radiation causes damage to the lipids and proteins of the cell membrane; and ionizing radiation a
Under de senaste decennierna har den personliga integriteten diskuterats i samband med flera lagstiftningsåtgärder i svensk rätt, inte minst i samband med ny lagstiftning inom straff- och straffprocessrätten. Flera straffrätts- bestämmelser har införts för att skydda den personliga integriteten mellan enskilda. Parallellt med denna utveckling har brottsbekämpande myndigheter tillgodosetts med nya In recent decades, personal integrity has been discussed in connection with several legislative measures in Swedish law, especially concerning new legislative measures in penal law and criminal procedure law. Several penal law measures have come into force to protect individuals’ privacy. At the same time, law enforcement agencies have been provided with new secret coercive measures which means th
Increasing demand for metals might lead to extraction of metals from materials, previously, thought of as waste. A letter by the Swedish Environmental Protection Agency and Geological Survey of Sweden from 2017 encouraged new and innovative waste treatments as well as recycling of waste produced in association with mining. The conventional treatment of acid mine wastewater creates large volumes of
The Swedish consumers consumed in 2014 13.1 kilo textilies, of this 8 kilogram was dicarded via household waste and used for energy production. European Union’s waste hierarchy avocates a higher rate of reuse and recycling for a more sustainable textile flow. The Swedish goverment is, therefor, working toward new laws and guidelines which can lead to an expanded responsibility for the municipaliti
