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OBJECTIVE: Rapid and early detection of patients at risk to develop sepsis remains demanding. Heparin-binding protein (HBP) has previously demonstrated good prognostic properties in detecting organ dysfunction among patients with suspected infections. This study aimed to evaluate the plasma-levels of HBP as a prognostic biomarker for infection-induced organ dysfunction among patients seeking medic
BACKGROUND: Global inequalities in access to health care are reflected in differences in cancer survival. The CONCORD programme was designed to assess worldwide differences and trends in population-based cancer survival. In this population-based study, we aimed to estimate survival inequalities globally for several subtypes of childhood leukaemia.METHODS: Cancer registries participating in CONCORD
During the last glacial period Northern Hemisphere climate was characterized by extreme and abrupt climate changes, so-called Dansgaard-Oeschger (DO) events. Most clearly observed as temperature changes in Greenland ice-core records, their climatic imprint was geographically widespread. However, the temporal relation between DO events in Greenland and other regions is uncertain due to the chronolo
Carbapenem resistance is a rapidly growing threat to our ability to treat refractory bacterial infections. To understand how carbapenem resistance is mobilized and spread between pathogens, it is important to study the genetic context of the underlying resistance mechanisms. In this study, the resistomes of six clinical carbapenem-resistant isolates of five different species - Acinetobacter bauman
Aim of the study Predicting outcome of unconscious patients after successful resuscitation is challenging and better prognostic markers are highly needed. Ischemic heart disease is a common cause of out-of-hospital cardiac arrest (OHCA). Whether or not high-sensitivity troponin T (hs-TnT) is a prognostic marker among survivors of OHCA with both ischemic and non-ischemic aetiologies remains to be d
The rapid accumulation of ancient human genomes from various areas and time periods potentially enables the expansion of studies of biodiversity, biogeography, forensics, population history, and epidemiology into past populations. However, most ancient DNA (aDNA) data were generated through microarrays designed for modern-day populations, which are known to misrepresent the population structure. P
Objective: To study if a modified triage system at an Emergency Department (ED) combined with educational efforts resulted in reduced time to antibiotics and decreased length of hospital stay (LOS) for patients with severe infection. Methods: A retrospective, observational study comparing patients before and after the start of a new triage model at the ED of a University Hospital. After the implem
Objective: To develop automated immunoassays for the quantification of Cartilage Oligomeric Matrix Protein (COMP) and a COMP neoepitope in synovial fluid and to investigate their diagnostic potential in different joint conditions. Methods: Two sandwich immunoassays were developed for the quantification of COMP and a COMP neoepitope, using an automated analyser (IDS-iSYS, Immunodiagnostic Systems,
BACKGROUND: Blood phosphate levels are vulnerable to fluctuations and changes in phosphate levels are often neglected. The aim of this study was to evaluate whether deviations in phosphate levels correlate to higher 180-day overall mortality or morbidity. METHODS: Four thousand six hundred fifty-six patients with 19,467 phosphate values treated at the adult intensive care unit at Skåne University
Despite the lack of scientific evidence for the effectiveness of Flexible Assertive Community Treatment (Flexible ACT), the model disseminates rapidly in the mental health services in a number of countries. This is in contrast to many evidence-based practices that often face comprehensive implementation barriers. Knowledge is needed on the dissemination of Flexible ACT to understand the relative s
Aim. This paper is a report of a study to elucidate families' lived experience of diabetes one year after a child was diagnosed with type 1 diabetes. Background. The incidence of type 1 diabetes is rapidly increasing worldwide, with a shift towards younger age groups. This illness is treated by means of an intensive management regimen that often disrupts the child's usual activities and requires d
Many paleoceanographic reconstructions of the glacial North Atlantic include estimates of iceberg discharge, which are based on the variable abundance of ice-rafted detritus (IRD) in deep-sea sediments. IRD abundance is most often determined by the mechanical separation and painstaking counting of terrigenous particles larger than a specified threshold grain size, typically 150 mum. Here we presen
If one takes a closer look at almost any building facade one will find biological growth. Although this can be seen as an integral part of an antique building, for modern buildings it is in most cases seen as an aesthetical problem. All building facades will most likely be discolored by biological growth by time, but in Sweden we have had many cases of newly built rendered facades that have been d
The rapid advances in life science, including the sequencing of the human genome and numerous other techiques, has given an extraordinary ability to aquire data on biological systems and human disease. Even so, drug development costs are higher than ever, while the rate of new approved treatments is historically low. A potential explanation to this discrepancy might be the difficulty of understand
Government agencies in Sweden are experiencing a communicative turn where notions concerning branding, image and identity have become standardized tools and concerns. Public relations, with its focus on persuasion and creating relations with external actors, is part of this communicative turn. This book is concerned with how government agencies practice political public relations in a more communi
Context. Intensity interferometry was invented and used by R.Hanbury Brown and R.Q.Twiss in the 1960's to measure stellar angular diameters. Its main advantage over conventional interferometry is that it enables very long baselines and is insensitive to poor seeing. However, because it requires very large light collectors, it was never pursued further. The Cherenkov Telescope Array (CTA) is a
Jura novit curia anses innebära att parterna inte kan binda domstolen vid vilken rättsregel som är tillämplig. Och inte heller hur denna rättsregel ska tolkas och tillämpas. Denna princip vållar emellertid vissa problem. Syftet med denna uppsats har varit att utreda om principen om jura novit curias omfattning enligt gällande rätt är välavvägd samt att annars ge förslag på bättre lösningar. PrinciIura novit curia implies that the parties cannot, with binding effect for the court, choose which law should be applied. Nor can they choose how the law should be interpreted or applied. The purpose of this paper was to investigate whether the extent of the principle of iura novit curia in Swedish law is balanced. If not so, the aim is to provide suggestions for a better solution. Iura novit curia
Convolutional neural networks (CNNs) have made rapid progress in the last years and in fields, such as computer vision, they are considered state-of-the-art. However, CNNs are very computationally intensive. This makes them challenging to use in embedded devices such as smartphones, security cameras and cars. This thesis investigates different neural network compression techniques to see which wi
Den svenska rättsstaten står inför allvarliga prövningar. Det grova våldet till följd av skjutvapen har ökat markant i Sverige, och risken för tredje man att drabbad av skjutningar och detonationer på offentlig plats har ökat. Samtidigt som våldet även blivit mer hänsynslöst och likgiltigt. Antalet brott inom denna kategori ökar, men uppklaringsandelen är låg. En förklaring till den dystra statistThe Swedish rule of law is facing serious challenges. The use of firearms resulting in severe injury has increased significantly in Sweden, and the risk of third parties being affected by shootings and detonations in public places has increased. At the same time, the violence has become more ruthless and indifferent. While this type of violence is increasing, law enforcement agencies are at a loss
En betydande del av alla offentliga upphandlingar leder till upprättande av ramavtal. Ramavtal är avtal som fastställer villkoren för kontrakt som senare ska tilldelas. EU-domstolen har i en dom från 2018 behandlat ett för upphandlingsområdet nytt fenomen. Domen rör takvolymer i ramavtal vilket avser en bestämd gräns för hur mycket som är tillåtet att avropa. Eftersom 2014 års direktiv och sedermA significant part of all public procurements leads to the conclusion of framework agreements. Framework agreements are agreements that define the terms of contracts to be awarded later. In a 2018 judgment, the European Court of Justice dealt with a new phenomenon for the procurement area. The judgment concerns determined volumes in framework agreements, which refer to a specific limit on how muc
