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A computer model of a patient-specific clinical (177)Lu-DOTATATE therapy dosimetry system is constructed and used for investigating the variability of renal absorbed dose and biologically effective dose (BED) estimates. As patient models, three anthropomorphic computer phantoms coupled to a pharmacokinetic model of (177)Lu-DOTATATE are used. Aspects included in the dosimetry-process model are the
A modified heat-moisture exchanger that incorporates a reflecting filter for use with partial rebreathing of exhaled volatile anaesthetics has been commercially available since the 1990s. The main advantages of the device are efficient delivery of inhaled sedation to intensive care patients and reduced anaesthetic consumption during anaesthesia. However, elevated arterial CO2 values have been obse
In this research, two objectives were pursued. Firstly, to develop an experience-focused approach to design, based on a framework for perceptual product experience, and, secondly, to test and verify the proposed methodology through an interior design study of the Hulme.F1 supercar. In the process, experience design criteria were developed, which served creative and evaluative purposes. The final d
All seals and cetaceans have lost at least one of two ancestral cone classes and should therefore be colour-blind. Nevertheless, earlier studies showed that these marine mammals can discriminate colours and a colour vision mechanism has been proposed which contrasts signals from cones and rods. However, these earlier studies underestimated the brightness discrimination abilities of these animals,
The feasibility of temperature and concentration measurements using near-IR (similar to 1.5 mu m) water spectra obtained by fiber laser intracavity spectroscopy was evaluated. The spectra were registered with water vapor heated in a tubular oven at temperatures between 1000 and 1300 K and in adiabatic flames where temperatures were above 1800 K. Adiabatic flames of methane were stabilized on the h
In times of ongoing urbanisation and unabated climate change, cities face increasing demands for improvements in urban climate change governance. This article investigates the activities of transnational municipal networks that were set up in response to climate change and analyses their potential to influence local climate governance. On the basis of a conceptualisation of transnational municipal
This paper presents a model that can calculate the uptake of CO2 in all existing concrete structures, including its uptake after service life. This is important for the calculation of the total CO2 uptake in the society and its time dependence. The model uses the well-documented cement use and knowledge of how the investments are distributed throughout the building sector to estimate the stock of
Flavours are biologically active molecules of large commercial interest in the food, cosmetics, detergent and pharmaceutical industry. The production of flavours can take place by either extraction from plant materials, chemical synthesis, through biological conversion of precursor molecules or through de novo biosynthesis. The latter alternatives are gaining importance through the rapidly growing
To estimate current and future avoidable smoking-attributable costs in Sweden for the year 2007.
This study compares two approaches to the estimation of social welfare intervention costs: one "top-down" and the other "bottom-up" for a group of social welfare clients with severe problem behavior participating in a randomized trial. Intervention costs ranging over a two-year period were compared by intervention category (foster care placement, institutional placement, mentorship services, indiv
We have engineered apolipoprotein A-I (apoA-I), a major protein constituent of high-density lipoprotein (HDL), to contain DOTA-chelated Gd(III) as an MRI contrast agent for the purpose of imaging reconstituted HDL (rHDL) biodistribution, metabolism and regulation in vivo. This protein contrast agent was obtained by attaching the thiol-reactive Gd[MTS-ADO3A] label at Cys residues replaced at four d
Abstract in UndeterminedTargeted proteomics via selected reaction monitoring (SRM) is a powerful mass spectrometric technique affording higher dynamic range, increased specificity and lower limits of detection than other shotgun mass spectrometry methods when applied to proteome analyses. However, it involves selective measurement of predetermined analytes, which requires more preparation in the f
Background: Birthweight and gestational age are key indicators for perinatal health obtained through the birth certificate. Knowing the validity of birth certificate data is crucial when identifying needs and evaluating birth outcomes. In Spain, vital information is reported by parents and is not checked for consistency with any hospital document. Therefore, to perform a validation study and descr
We present the first method to handle curvature regularity in region-based image segmentation and inpainting that is independent of initialization. To this end we start from a new formulation of length-based optimization schemes, based on surface continuation constraints, and discuss the connections to existing schemes. The formulation is based on a cell complex and considers basic regions and bou
Reading utilises at least two neural pathways. The temporal lexical route visually maps whole words to their lexical entries, whilst the nonlexical route decodes words phonologically via parietal cortex. Readers typically employ the lexical route for familiar words, but poor comprehension plus precocity at mechanically 'sounding out' words suggests that differences might exist in autism. Combined
The high Q-factor (low bandwidth) and low efficiency make the design of small antennas challenging. Here, convex optimization is used to determine current distributions that provide upper bounds on the antenna performance. Optimization formulations for maximal gain Q-factor quotient, minimal Q-factor for superdirectivity, and minimum Q for given far-fields are presented. The effects of antennas em
