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Evidence from neuropathological cohorts indicates that a CSF α-synuclein (α-syn) seed amplification assay (SAA) might provide quantitative kinetic parameters correlating with α-syn pathology burden in patients with Lewy body disease (LBD). Studies are needed to assess their longitudinal trend during the presymptomatic and clinical disease phases and their correlation with measures of disease progr
Achieving a robust ignition with minimal spark plug wear is challenging in heavy duty engines fueled with gaseous fuels like biogas and hydrogen. Thermal energy deposition from the spark to the gas was studied in a 10.9 milliliter custom-built spark calorimeter. An AC capacitive ignition system was used along with a dual-nickel standard J-gap spark plug and the influence of multiple physical and e
Across different domains, justice is considered either from a perspective concerning mind-independent features of a situation or from a perspective related to mind-dependent motives, traits or emotions. Although these approaches have generated valuable insights, they remain largely disconnected from each other. What is missing is an integrative framework that can explain how the objective features
Biografisk artikel om Claes Ludvig Ennes (1727-1791), lundastudent, skald, präst och informator till Carl Michael Bellman.
Surrogate measures of safety (SMoS) are meant to function as tools to investigate traffic safety. The term surrogate indicates that these measures do not rely on crash data; instead, they focus on identifying safety critical events (or near-crashes) in traffic, which can be used as an alternative to crash records. The overall aim of this thesis is to explore which SMoS are suitable when analysing
OBJECTIVE: To study the pharmacodynamics of amoxicillin/clavulanic acid against different strains of Haemophilus influenzae in an in vitro kinetic model. The concentrations used corresponded to human serum levels obtained after 875 mg amoxicillin/clavulanic acid given b.i.d., 500/125 mg amoxicillin/clavulanic acid given t.i.d. and those obtained with a pharmacokinetically enhanced formulation cont
This study investigates to what extent an aqueous two-phase system (ATPS) can encapsulate and protect the secondary structure of a protein during spray drying. The ATPSs contained polyvinyl alcohol (PVA) and dextran solutions, in different proportions. A model protein, bovine serum albumin (BSA) and, in some experiments, trehalose were added to the ATPS prior to spray drying. Electron spectroscopy
Electric road systems (ERSs) present a transformative advancement in transportation electrification, offering continuous charging capabilities for electric vehicles (EVs) during travel. This innovation has the potential to significantly mitigate range anxiety by enabling in-motion charging, thereby enhancing the overall efficiency of electric mobility, and reducing the frequency of charging stops
This chapter argues that how the neoliberal notion of ‘attractive space’ emerged as a planning paradigm in the renewal of the Western Harbor district of Malmö, Sweden, unleashed powerful contradictions. The chapter shows that although the urban design of the area was intended to attract affluent residents from the suburbs to the city, people from less affluent and more ethnically diverse areas of
IMPORTANCE: The number of patients prescribed long-term opioids and benzodiazepines and complications from their long-term use have increased. Information regarding the perioperative outcomes of patients prescribed these medications before surgery is limited.OBJECTIVE: To determine whether patients prescribed opioids and/or benzodiazepines within 6 months preoperatively would have greater short- a
Reflections on the need for Question Zero in AI-kommissionensFärdplan Sverige.
This article examines the economic incentives for Europeans to migrate to the so-called 'white man's grave' of West Africa. Ignorance and coercion have been proposed as explanations for migration to high mortality areas. We use data on the Royal African Company and their European employees on the Gold Coast during the period 1707-1740. We found that the employees received a premium above the wage
Background: Despite recent advances in neuroimaging and neurocritical care, severe traumatic brain injury (TBI) is still a major cause of severe disability and mortality, with increasing incidence worldwide. Antisecretory factor (AF), commercially available as Salovum®, has been shown to lower intracranial pressure (ICP) in experimental models of, e.g., TBI and herpes encephalitis. The aim of this
