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Parametric design systems serve as powerful assistive tools in the design process by providing a flexible approach for the generation of a vast number of design alternatives. However, contemporary parametric design systems focus primarily on low-level engineering and structural forms, without an explicit means to also take into account high-level, cognitively motivated people-centred design goals.
Automated cryptanalysis has seen a lot of attraction and success in the past decade, leading to new distinguishers or key-recovery attacks against various ciphers. We argue that the improved efficiency and usability of these new tools have been undervalued, especially for design processes. In this article, we break for the first time the classical iterative design paradigm for symmetric-key primit
Metachromatic leukodystrophy (MLD) is a fatal, progressive neurodegenerative disorder caused by biallelic pathogenic mutations in the ARSA (Arylsulfatase A) gene. With the advent of presymptomatic diagnosis and the availability of therapies with a narrow window for intervention, it is critical to define a standardized approach to diagnosis, presymptomatic monitoring, and clinical care. To meet the
This paper highlights the lives of Japanese and Korean subjects of Imperial Japan who were involved in opium production and circulation in Manchukuo. It discusses the dynamics, practices, and experiences of opium production and circulation. This paper provides a new reading of the diverse beneficiaries on the ground and of the opium industry in Manchukuo from the angles of production and circulati
Synaptic dysfunction and degeneration is likely the key pathophysiology for the progression of cognitive decline in various dementia disorders. Synaptic status can be monitored by measuring synaptic proteins in CSF. In this study, both known and new synaptic proteins were investigated and compared as potential biomarkers of synaptic dysfunction, particularly in the context of Alzheimer's disease (
Purpose: This article proposes diffractive vignettes as a new analytical approach that can sensitize organizational communication research to extra/linguistic forces in the communicative constitution of major societal challenges such as the climate crisis. The critical feminist concept of diffraction examines how diverse forces interact, interfere, and produce new patterns of meaning and differenc
Background: While shared decision making is a cornerstone of orthopedic care, orthopedic surgeons face challenges in tailoring their advice and expectation management to individual shoulder arthroplasty patients due to the lack of systematically summarized evidence-based knowledge. This systematic review aims to provide an overview of current knowledge on independent predictive effects of patient-
In the transition to a circular economy there is a need to advance the understanding of how consumer acceptance of circular product-service systems (PSS) can be fostered, since the lack thereof inhibits their adoption and diffusion. This study therefore aims to enhance the understanding of circular PSS acceptance by making two main contributions. First, it proposes a framework that provides a stru
Refugees drown, are beaten, and are pushed back at the borders of the states of the Global North. Moral outrage is understandable in the face of such treatment. But does it constitute a good political theory? Can morality supply us with good normative arguments for a political world? In this article, I argue that they cannot. Drawing on political realism, I show why moral arguments for admitting r
For the Inner Tracking System 3 (ITS3) upgrade, the ALICE experiment at CERN requires monolithic active pixel sensors of dimensions up to 97 mm×266 mm, occupying a large fraction of a 300 mm wafer. To manufacture such a wafer-scale device, larger than the single design reticle size, stitching is employed. The MOnolithic Stitched Sensor (MOSS) is a prototype silicon pixel sensor of 14 mm×259 mm siz
Water management is a critical factor for the performance and reliability of polymer electrolyte fuel cells (PEFCs) operating as energy generation systems. Inadequate operating conditions may lead to non-uniform water distribution, resulting in membrane dehydration or flooding of porous media, both of which adversely affect cell operation. In this work, a two-dimensional reduced-order model is dev
In fixed-bed reactors, the use of large particles in thermally thick regimes is common, which underscores the need for a comprehensive understanding of intraparticle processes. However, integrating detailed particle models into fixed-bed simulations is computationally expensive. This study introduces a tabulation method for biomass conversion’s drying and pyrolysis stages, where significant mass e
Rivers play a fundamental role in shaping the Earth’s surface and sustaining ecosystems. Accurate modeling and simulation of stream power are essential for understanding fluvial processes. As a measure of the energy exerted by overland flow, stream power possesses both magnitude and directional attributes. However, conventional simulation approaches based on scalar operations often neglect the dir
BACKGROUND: The aim was to improve the realism of patient models for Monte-Carlo based evaluation of image-based quantification of tumour volume and activity in [68Ga]Ga-DOTA-TOC PET and [177Lu]Lu-DOTA-TATE SPECT images.METHODS: Three phantoms from the XCAT population were used as basis. Tumour structures were obtained from segmentation of patient 68Ga-PET images and positioned at relevant positio
In the fast-evolving arena of climate finance, equitable access to and allocation of funds for adaptation continue to pose a significant and urgent challenge. In theory, to prepare for the impacts of climate change in an equitable way, regional, national, and European Union (EU) funding tenders on climate adaptation should prioritize the most climate-vulnerable local administrations. However, evid
