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Impact of Cardiovascular Neurohormones on Onset of Vasovagal Syncope Induced by Head-up Tilt.

BackgroundVasovagal reflex is the most common form of syncope, but the pathophysiological mechanisms that initiate the reflex are not well understood. We aimed to study supine and early orthostatic levels of the neurohormones involved in control of circulatory homeostasis in relation to the onset of tilt‐induced vasovagal syncope (VVS).Methods and ResultsA total of 827 patients who were investigat

Economic Evaluation of Elective Cesarean Section on Maternal Request Compared With Planned Vaginal Birth—Application to Swedish Setting Using National Registry Data

Objectives: There is a lack of consensus around the definition of delivery by cesarean section (CS) on maternal request, and clinical practice varies across and within countries. Previous economic evaluations have focused on specific populations and selected complications. Our aim was to evaluate the cost-effectiveness of CS on maternal request compared with planned vaginal birth in a Swedish cont

Pulmonary embolism and deep venous thrombosis after COVID-19 : long-term risk in a population-based cohort study

Background: Venous thromboembolism (VTE) (pulmonary embolism [PE] or deep venous thrombosis [DVT]) is common during acute COVID-19. Long-term excess risk has not yet been established. Objectives: To study long-term VTE risk after COVID-19. Methods: Swedish citizens aged 18 to 84 years hospitalized and/or testing positive for COVID-19 between January 1, 2020, and September 11, 2021 (exposed), strat

Spectrally Tunable Broadband Gate-All-Around InAsP/InP Quantum Discs-in-Nanowire Array Phototransistors with a High Gain-Bandwidth Product

High-performance broadband photodetectors offering spectral tunability and a high gain-bandwidth product are crucial in many applications. Here, we report on a detailed experimental and theoretical study of three-terminal phototransistors comprised of three million InP nanowires with 20 embedded InAsP quantum discs in each nanowire. A global, transparent ITO gate all around the nanowires facilitat

Joint tenderness at 3 months follow-up better predicts long-term pain than baseline characteristics in early rheumatoid arthritis patients

OBJECTIVE: To investigate pain course over time and to identify baseline and 3-month predictors of unacceptable pain with or without low inflammation in early RA.METHODS: A cohort of 275 patients with early RA, recruited in 2012-2016, was investigated and followed for 2 years. Pain was assessed using a visual analogue scale (VAS; 0-100 mm). Unacceptable pain was defined as VAS pain >40, and low in

A hypothesis - generating Swedish extended national cross-sectional family study of multimorbidity severity and venous thromboembolism

OBJECTIVES: Venous thromboembolism (VTE) is a common worldwide disease. The burden of multimorbidity, that is, two or more chronic diseases, has increased. Whether multimorbidity is associated with VTE risk remains to be studied. Our aim was to determine any association between multimorbidity and VTE and any possible shared familial susceptibility.DESIGN: A nationwide extended cross-sectional hypo

Electronic structure and transport in exotic nanostructures

This thesis explores the physics of nanostructures involving nanowires, quantum dots, superconductors, and topological insulators. These systems serve as excellent platforms for fundamental physics studies and quantum technology applications.The introduction contains information on the band structures of crystalline materials and transport phenomena in quantum dots. It is followed by discussions o

Different Doping Behaviors of Silicon in Zinc Blende and Wurtzite GaAs Nanowires : Implications for Crystal-Phase Device Design

Crystal-phase engineering between zinc blende (ZB) and wurtzite (WZ) structures is becoming an important method in designing unique optoelectronic and electronic semiconductor devices. Doping to engineer their electric properties is thus of critical importance, but a direct experimental comparison in doping these two crystal structures is still missing. Nanowires (NWs) allow the coexistence of bot

Genetics of diabetes-associated microvascular complications

Diabetes is associated with excess morbidity and mortality due to both micro- and macrovascular complications, as well as a range of non-classical comorbidities. Diabetes-associated microvascular complications are those considered most closely related to hyperglycaemia in a causal manner. However, some individuals with hyperglycaemia (even those with severe hyperglycaemia) do not develop microvasc

Telepresence robotic technology support for social connectedness during treatment of children with cancer

Children with cancer experience fragmented school attendance during treatment. Telepresence robots that connect them with school during treatment periods were explored through an intervention involving participant observation followed by semi-structured interviews from 2020–22 with children with cancer, their class teachers, and classmates. We used an abductive approach, inspired by the Agential R

Exposure to hand-held vibrating tools and biomarkers of nerve injury in plasma : A population-based, observational study

Objectives To analyse potential biomarkers for vibration-induced nerve damage in a population-based, observational study. Design Prospective cohort study. Setting Malmö Diet Cancer Study (MDCS), Malmö, Sweden. Participants In a subcohort of 3898 individuals (recruited 1991-1996) from MDCS (baseline examination in 28 449 individuals; collection of fasting blood samples in a cardiovascular subcohort

Response to Comment on “The lower Cambrian lobopodian Cardiodictyon resolves the origin of euarthropod brains”

Budd et al. challenge the identity of neural traces reported for the Cambrian lobopodian Cardiodictyon catenulum. Their argumentation is unsupported, as are objections with reference to living Onychophora that misinterpret established genomic, genetic, developmental, and neuroanatomical evidence. Instead, phylogenetic data corroborate the finding that the ancestral panarthropod head and brain is u

Nonsinusoidal current-phase relations in semiconductor-superconductor- ferromagnetic insulator devices

Coherent tunneling processes of multiple Cooper pairs across a Josephson junction give rise to high harmonics in the current phase relation. In this work, we propose and study Josephson junctions based on semiconductor-superconductor-ferromagnetic insulator heterostructures to engineer nonsinusoidal current-phase relations. The gate-tunability of the charge carriers' density in the semiconductor,

Optimization of Chemical Bonding through Defect Formation and Ordering-The Case of Mg7Pt4Ge4

The new phase Mg7Pt4Ge4 (Mg8□1Pt4Ge4; □ = vacancy) was prepared by reacting a mixture of the corresponding elements at high temperatures. According to single crystal X-ray diffraction data, it adopts a defect variant of the lighter analogue Mg2PtSi (Mg8Pt4Si4), reported in the Li2CuAs structure. An ordering of the Mg vacancies results in a stoichiometric phase, Mg7Pt4Ge4. However, the high content

Forensic assessment of single stab injuries to the trunk

IntroductionForensic pathologists are frequently confronted with questions about the likelihood that an injury is inflicted by an assault or is self-inflicted. However, little is known of epidemiological variables applicable to differentiate between homicides and suicides in deaths caused by single stab injuries to the trunk. MethodUsing the Swedish forensic autopsy register we identified 94 homic

Stroke survivors’ preferences regarding study participation in rehabilitation research

Background: To pursue high quality research, successful participant recruitment is essential, but recruitment rates are often low. This is specifically true in target populations with impairments, for instance, among stroke survivors. Previous studies focusing on recruitment have mainly relied on information from professionals, and there is therefore a need to contribute with new methodological in

Solubility of Aβ40 peptide

In this work we measured, by using a direct approach, the equilibrium solubility of recombinant Aβ40 peptide to be S ​= ​0.36 ​± ​0.15 ​μM in aqueous solution of 20 ​mM sodium phosphate buffer at pH 7.4. Microfluidic diffusional sizing (MDS) and mass spectrometry (MALDI-TOF/TOF) with isotope standard were used to quantify the concentration of soluble Aβ40 species coexisting with formed fibrils. A

Carpal Tunnel Syndrome and Diabetes—A Comprehensive Review

Carpal tunnel syndrome (CTS) is the most common compression neuropathy in the general population and is frequently encountered among individuals with type 1 and 2 diabetes. The reason(s) why a peripheral nerve trunk in individuals with diabetes is more susceptible to nerve compression is still not completely clarified, but both biochemical and structural changes in the peripheral nerve are probabl