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HbA(1c) Measured in Stored Erythrocytes Is Positively Linearly Associated with Mortality in Individuals with Diabetes Mellitus

Introduction: Observational studies have shown that glycated haemoglobin (HbA(1c)) is related to mortality, but the shape of the association is less clear. Furthermore, disease duration and medication may modify this association. This observational study explored the association between HbA(1c) measured in stored erythrocytes and mortality. Secondly, it was assessed whether disease duration and me

Low/Negative Expression of PDGFR-α Identifies the Candidate Primary Mesenchymal Stromal Cells in Adult Human Bone Marrow.

Human bone marrow (BM) contains a rare population of nonhematopoietic mesenchymal stromal cells (MSCs), which are of central importance for the hematopoietic microenvironment. However, the precise phenotypic definition of these cells in adult BM has not yet been reported. In this study, we show that low/negative expression of CD140a (PDGFR-α) on lin(-)/CD45(-)/CD271(+) BM cells identified a cell p

TCF7L2 Polymorphism, Weight Loss and Proinsulin: Insulin Ratio in the Diabetes Prevention Program

Aims: TCF7L2 variants have been associated with type 2 diabetes, body mass index (BMI), and deficits in proinsulin processing and insulin secretion. Here we sought to test whether these effects were apparent in high-risk individuals and modify treatment responses. Methods: We examined the potential role of the TCF7L2 rs7903146 variant in predicting resistance to weight loss or a lack of improvemen

Law, Norms, Piracy and Online Anonymity – Practices of de-identification in the global file sharing community

Purpose The purpose of this study is to better understand online anonymity in the global file-sharing community in the context of social norms and copyright law. The study describes the respondents in terms of use of Virtual Private Networks (VPNs) or similar services with respect to age, gender, geographical location, as well as analysing the correlation with file-sharing frequencies. Design/me

Walkability parameters, active transportation and objective physical activity: moderating and mediating effects of motor vehicle ownership in a cross-sectional study

Background: Neighborhood walkability has been associated with physical activity in several studies. However, as environmental correlates of physical activity may be context specific, walkability parameters need to be investigated separately in various countries and contexts. Furthermore, the mechanisms by which walkability affects physical activity have been less investigated. Based on previous re

Beyond the Creative Commons Framework for Production and Dissemination of Knowledge

This thesis is about the licensing system of the Creative Commons discussed from the perspective of the theory of the commons mostly as formulated by Elinor Ostrom. The work is started by describing the concepts and theory of common pool resources and regime of the commons for production and distribution of these resources. The main characteristics for successful traditional commons – efficiency,

The Proposed Regulation on a Common European Sales Law (CESL) as an Alternative to the Convention on the International Sale of Goods (CISG) in Transnational Business-to-Business Transactions?

The Commission has put forth a proposal for a Regulation on a Common European Law of Sales (CESL). It is envisaged – as of now – as an optional second regime within each member state‘s law, electable for transnational consumer contracts and contracts among traders, as long as one of them is a small or medium-sized enterprise. The intention is to provide contractors with a level playground of one l

Reverse Payment Patent Settlements as Restrictions by Object under Article 101(1) TFEU

Förevarande uppsats undersöker EU-domstolens praxis avseende värdeöverföringar mellan originaltillverkare av läkemedel och generikaföretag i samband med patentförlikningar (så kallade ‘RPPSs’) för att urskilja under vilka förutsättningar ett sådant förfarande utgör en syftesöverträdelse. Analysen visar att EU-domstolens avgöranden Generics och Lundbeck förtydligar bedömningen av mer okompliceradeThis thesis examines the CJEU’s case law on value transfers between originator and generic undertakings, in the context of patent settlements, to ascertain the criteria for determining when such a practice amounts to a restriction of competition by object. The thesis finds that the CJ’s rulings in Generics and Lundbeck clarifies the treatment of more straightforward RPPSs and follows established

Integritet: En kvalitativ undersökning kring hur onlinetjänster bättre kan tillgodose den digitala konsumentens önskemål kring datainsamling

Det råder en global kontinuerlig teknikutveckling som präglar internet med nya innovationer. Många onlinetjänster på internet bedriver sina verksamheter med hjälp av datainsamling av de digitala konsumenterna. Teknikutveckling kräver en insats från både onlinetjänster som behöver vara fortsatt anpassningsbara och digitala konsumenter som behöver begripa vilka konsekvenser utveckling har. Datainsam

Det tredelade föräldraskapet - begreppet utan definition. En kvantitativ studie om yrkesverksammas kunskapsläge, arbetssätt och attityd till det tredelade föräldraskapet

Three-part parenting is an approach that social services in Sweden should use in collaboration around a child placed in foster care. It describes how foster home, parents and social services share responsibilities for the welfare of the child. The purpose of this study was to illuminate the state of knowledge about the approach among social workers working with children and adolescents in Sweden.

"Vi kan ju bara motivera" - En studie om självbestämmande på LSS-boende

The aim of this study is to investigate how staff who work with persons with mental impairment living in supportive housing describe and reflect on the clients´ self-determination and which options and challenges they experience with respect to putting the intent of the Swedish act concerning support and service for people with certain functional impairments (LSS) regarding self-determination into

Arbetstagares kritikrätt - Skillnader mellan offentlig och privat sektor samt implikationer av Europadomstolens praxis

Det ena syftet med denna uppsats är att undersöka skillnaderna mellan den offentliga och den privata sektorn ifråga om arbetstagares kritikrätt. Det andra syftet är att undersöka konsekvenserna för denna rättighet av en dom från Europadomstolen, Fuentes Bobo mot Spanien. Offentligt anställda har en grundlagsskyddad yttrandefrihet, som kan utnyttjas i princip i vilken situation som helst. Begränsni

Förekommer det ett samband mellan styrelseledamöters parallella styrelseuppdrag och företags tillväxt? / Is there a connection between board of director’s parallel board assignments and company’s growth?

Syftet med vår uppsats är att undersöka om det finns ett samband mellan medelstora aktiebolags tillväxt och styrelseledamöters antal parallella styrelseuppdrag och hur detta samband i sådant fall ser ut. // To investigate if there is a connection between the board of director’s number of parallel board assignments and the growth of midsized corporations. And if that’s the case then see how this co

UN vs OECD Model Tax Conventions - An alternative for development through formulary apportionment?

The purpose of this thesis is to evaluate the compatibility of the current dominant approach in international taxation for intragroup transactions, based on arm’s length principle, with international agreements on development. In this sense, the thesis aims to explore the viability of formulary apportionment as an alternative that could reduce contradictions between international tax law and devel

The Development Path Divergence between Guatemala and Costa Rica. A Social Capability Approach, 1985-2020

This thesis investigates the outcomes of economic divergence during the neoliberal period in Guatemala and Costa Rica (1985-2020). The application of social capabilities: transformation, autonomy, inclusion and accountability allowed us not only to show the diverted social and economic paths, but also to inspect further and delve into the complex social dynamics in place. There was significant pro

Artificiell Intelligens och Kundservice: En omvälvande revolution och dess effekter på kundupplevelsen.

Studieobjekt: AI-chatbots, serviceinteraktioner och kundupplevelser. Problemområde: Begränsat med forskning om serviceinteraktioner och kundupplevelser till följd av AI-chatbots. Syfte: Studiens syfte är att undersöka hur kundupplevelsen påverkas i serviceinteraktioner. Vi gör detta genom att fokusera på servicemöten samt service recovery-processer inom detaljhandeln, vården samt hotell- och tra