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Rational, autonomous agents that are able to achieve their goals in dynamic, partially observable environments are the ultimate dream of Artificial Intelligence research since its beginning. The goal of this PhD thesis is to propose, develop and evaluate a framework well suited for creating intelligent agents that would be able to learn from experience, thus becoming more efficient at solving thei

A capillary filling microfluidic proteomic sample processing system has been realized in an automated set-up. Chip-integrated solid-phase extraction is performed in a 96-array format followed by sequential capillary action elution into a piezoelectric microdispenser and subsequent transfer to MALDI targets. Samples are eluted and deposited in volumes of 200–300 nl. The robotic system offers calibr

A set of successively more accurate self-consistent equations for the one-electron Green's function have been derived. They correspond to an expansion in a screened potential rather than the bare Coulomb potential. The first equation is adequate for many purposes. Each equation follows from the demand that a corresponding expression for the total energy be stationary with respect to variations in

Antibodies to citrulline-modified proteins have a high diagnostic value in rheumatoid arthritis (RA). However, their biological role in disease development is still unclear. To obtain insight into this question, a panel of mouse monoclonal antibodies was generated against a major triple helical collagen type II (CII) epitope (position 359-369; ARGLTGRPGDA) with or without arginines modified by cit

Study commissioned by BIL Sweden for the Committee for Producer Responsibility Review (M 2000:01) på uppdrag av BIL Sweden

Many problems concerning resource management in modern communication systems can be simplified to queueing models under Markovian assumptions. The computation of the optimal policy is however often hindered by the curse of dimensionality especially for models that support multiple traffic or job classes. The research focus naturally turns to computationally efficient bounds and high performance he

In this thesis, liquid-membrane-based methods for the analysis of trace metal species in samples of environmental and biological origin were developed. By incorporating extracting reagents in the membrane liquid, trace metal ions were selectively separated from humic-rich natural waters and urine samples, prior to their determination using various instrumental techniques. The extractions were perf

Fuel cells are electrochemical devices that transform chemical energy into electricity. Solid oxide fuel cells (SOFCs) are particularly interesting because they can handle the reforming of hydrocarbon fuels directly within the cell. This is possible due to their high operating temperature. The purpose of this study is to develop an anode-supported SOFC model, to enhance the understanding of the in

That a load balancing strategy using stale information care lessly will incur system performance degradation is easy to verify. However it is not so obvious that routing a customer to the expected shortest queue has the same problem when information for decision is stale. We consider a queueing system with a load balancer and a pool of identical FCFS queues in parallel. The arrival process is assu

Knowledge about the nature, processes and patterns of cascading effects, i.e. where infrastruc-ture dependencies lead to impacts propagating from one system to other systems, is essential in order to miti-gate and respond to crises that involve critical infrastructures and societal functions. This paper presents a method for systematic description of cascading effects in past event, to some extent

Thread-Level Speculation can be used to take advantage of multicore architectures for web applications. We have implemented Thread-Level Speculation in the state-of-the-art JavaScript engine V8 instead of using an interpreted JavaScript engine. We evaluate the implementation with the Chromium web browser on 15 popular web applications for 2, 4, and 8 cores. The results show that it is beneficial t

It is widely accepted that firms in peripheral regions benefit to a lesser extent from local knowledge spillovers than firms located in agglomerations or industrial clusters. This paper investigates the extent to which innovative firms in peripheral regions compensate for the lack of access to local knowledge spillovers by collaborating at other geographical scales. So far the literature predomina

Newton-Raphson and Goldschmidt algorithms can be sped up by using variable latency hardware architectures for rounding division, square root and their reciprocals. A new approach based on a rounding method with remainder estimate calculated concurrently with the algorithm was proposed in [5]. This paper presents an study of the hardware implementation of this approach and shows that does not suppo

Expression microarray analysis identified over 930 genes regulated during puberty in the mouse mammary gland. Most prominent were genes whose expression increased in parallel with pubertal development and remained high thereafter. Members of the Wnt, transforming growth factor-beta and oestrogen-signalling pathways were significantly overrepresented. Comparison to expression data from CITED1 knock

To obtain full sky coverage, astronomical adaptive optics systemsrequire Na Sodium Beacons (SBs) (also referred to as Laser Guide Starsor LGSs) located at heights extending from 85 to 100 km. When viewed atthe edge of large telescopes these SBs appear elongated. For the Euro5050 meter aperture telecopes this elongation amounts to 6 to 9 arcsecondswhen the laser is launched from a point on the tele